DOK6 — 35 ClinVar variants
All ClinVar germline DOK6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
35 Uncertain significance
Full DOK6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOK6 p.Ala226Val Uncertain significance Single submitter
- DOK6 p.Ala267Thr Uncertain significance Single submitter
- DOK6 p.Ala304Ser Uncertain significance Single submitter
- DOK6 p.Arg19Lys Uncertain significance Single submitter
- DOK6 p.Arg274His Uncertain significance Single submitter
- DOK6 p.Asn117Ser Uncertain significance Single submitter
- DOK6 p.Gln313His Uncertain significance Single submitter
- DOK6 p.Glu240Gln Uncertain significance Single submitter
- DOK6 p.Glu97Asp Uncertain significance Single submitter
- DOK6 p.Gly113Glu Uncertain significance Single submitter
- DOK6 p.Ile8Val Uncertain significance Single submitter
- DOK6 p.Leu21Phe Uncertain significance Single submitter
- DOK6 p.Lys293Thr Uncertain significance Single submitter
- DOK6 p.Lys76Arg Uncertain significance Single submitter
- DOK6 p.Met144Arg Uncertain significance Single submitter
- DOK6 p.Met144Leu Uncertain significance Single submitter
- DOK6 p.Met144Thr Uncertain significance Single submitter
- DOK6 p.Met218Thr Uncertain significance Single submitter
- DOK6 p.Phe211Ile Uncertain significance Single submitter
- DOK6 p.Ser316Leu Uncertain significance Single submitter
- DOK6 p.Ser316Pro Uncertain significance Single submitter
- DOK6 p.Thr195Met Uncertain significance Single submitter
-
DOK6 p.Tyr321Ser
Uncertain significance
Single submitter
Inborn genetic diseases
- DOK6 p.Val278Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DOK6 p.Arg246Gln Uncertain significance Single submitter
- DOK6 p.Arg246Leu Uncertain significance Single submitter
- DOK6 p.Arg246Trp Uncertain significance Single submitter
- DOK6 p.Arg274Cys Uncertain significance Single submitter
- DOK6 p.Asp86Asn Uncertain significance Single submitter
- DOK6 p.Glu87Lys Uncertain significance Single submitter
- DOK6 p.Phe31Leu Uncertain significance Single submitter
- DOK6 p.Ser262Cys Uncertain significance Single submitter
- DOK6 p.Ser327Tyr Uncertain significance Single submitter
- DOK6 p.Ser89Leu Uncertain significance Single submitter
- DOK6 p.Thr192Ala Uncertain significance Single submitter
All DOK6 variants
Uncertain significance 35
- p.Ala226Val Single submitter ⚠
- p.Ala267Thr Single submitter ⚠
- p.Ala304Ser Single submitter ⚠
- p.Arg19Lys Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg246Leu Single submitter ⚠
- p.Arg246Trp Single submitter ⚠
- p.Arg274Cys Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Asn117Ser Single submitter ⚠
- p.Asp86Asn Single submitter ⚠
- p.Gln313His Single submitter ⚠
- p.Glu240Gln Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Glu97Asp Single submitter ⚠
- p.Gly113Glu Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Lys293Thr Single submitter ⚠
- p.Lys76Arg Single submitter ⚠
- p.Met144Arg Single submitter ⚠
- p.Met144Leu Single submitter ⚠
- p.Met144Thr Single submitter ⚠
- p.Met218Thr Single submitter ⚠
- p.Phe211Ile Single submitter ⚠
- p.Phe31Leu Single submitter ⚠
- p.Ser262Cys Single submitter ⚠
- p.Ser316Leu Single submitter ⚠
- p.Ser316Pro Single submitter ⚠
- p.Ser327Tyr Single submitter ⚠
- p.Ser89Leu Single submitter ⚠
- p.Thr192Ala Single submitter ⚠
- p.Thr195Met Single submitter ⚠
- p.Tyr321Ser Single submitter Inborn genetic diseases ⚠
- p.Val278Ile Single submitter ⚠