DOLPP1 — 20 ClinVar variants
All ClinVar germline DOLPP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Likely benign · 18 Uncertain significance
Full DOLPP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOLPP1 p.Arg206Gln Uncertain significance Single submitter
- DOLPP1 p.Arg229Gly Uncertain significance Single submitter
- DOLPP1 p.Asn213Ser Uncertain significance Single submitter
- DOLPP1 p.Gln6Glu Uncertain significance Single submitter
- DOLPP1 p.Gly65Asp Uncertain significance Single submitter
- DOLPP1 p.His31Tyr Uncertain significance Single submitter
- DOLPP1 p.Ser114Phe Uncertain significance Single submitter
- DOLPP1 p.Thr19Ile Uncertain significance Single submitter
- DOLPP1 p.Val186Phe Uncertain significance Single submitter
- DOLPP1 p.Val214Ile Uncertain significance Single submitter
- DOLPP1 p.Val45Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DOLPP1 p.Ala224Val Uncertain significance Single submitter
- DOLPP1 p.Asn78Thr Uncertain significance Single submitter
- DOLPP1 p.Leu190Arg Uncertain significance Single submitter
- DOLPP1 p.Pro24Ala Uncertain significance Single submitter
- DOLPP1 p.Ser153Gly Uncertain significance Single submitter
- DOLPP1 p.Tyr119His Uncertain significance Single submitter
- DOLPP1 p.Val138Met Uncertain significance Single submitter
All DOLPP1 variants
Likely benign 2
- p.Ala145Thr Single submitter
- p.Gly173Ser Single submitter
Uncertain significance 18
- p.Ala224Val Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg229Gly Single submitter ⚠
- p.Asn213Ser Single submitter ⚠
- p.Asn78Thr Single submitter ⚠
- p.Gln6Glu Single submitter ⚠
- p.Gly65Asp Single submitter ⚠
- p.His31Tyr Single submitter ⚠
- p.Leu190Arg Single submitter ⚠
- p.Pro24Ala Single submitter ⚠
- p.Ser114Phe Single submitter ⚠
- p.Ser153Gly Single submitter ⚠
- p.Thr19Ile Single submitter ⚠
- p.Tyr119His Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val186Phe Single submitter ⚠
- p.Val214Ile Single submitter ⚠
- p.Val45Ile Single submitter ⚠