DORIP1 — 6 ClinVar variants
All ClinVar germline DORIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
4 Benign · 2 Uncertain significance
Full DORIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All DORIP1 variants
Benign 4
- p.Glu309Asp Multiple submitters
- p.Leu66= Multiple submitters
- p.Pro177Leu Single submitter
- p.Ser234Phe Single submitter
Uncertain significance 2
- p.Leu282Phe Single submitter ⚠
- p.Ser148Phe Single submitter ⚠