DPCD — 32 ClinVar variants
All ClinVar germline DPCD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 1 Likely benign · 30 Uncertain significance
Full DPCD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPCD p.Ala155Thr Uncertain significance Single submitter
- DPCD p.Ala193Thr Uncertain significance Single submitter
- DPCD p.Ala89Gly Uncertain significance Single submitter
- DPCD p.Ala89Thr Uncertain significance Single submitter
- DPCD p.Arg105Trp Uncertain significance Single submitter
- DPCD p.Arg53Ser Uncertain significance Single submitter
- DPCD p.Asp197Gly Uncertain significance Single submitter
- DPCD p.Asp21Glu Uncertain significance Single submitter
- DPCD p.Gly198Glu Uncertain significance Single submitter
- DPCD p.Gly75Glu Uncertain significance Single submitter
- DPCD p.Gly80Glu Uncertain significance Single submitter
- DPCD p.Leu18Pro Uncertain significance Single submitter
- DPCD p.Lys135Gln Uncertain significance Single submitter
- DPCD p.Thr131Pro Uncertain significance Single submitter
- DPCD p.Trp6Cys Uncertain significance Single submitter
- DPCD p.Tyr137His Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DPCD p.Leu156Ser Benign Multiple submitters
- DPCD p.Ala155Pro Uncertain significance Single submitter
- DPCD p.Arg125Cys Uncertain significance Single submitter
- DPCD p.Arg125His Uncertain significance Single submitter
- DPCD p.Arg95His Uncertain significance Single submitter
- DPCD p.Asp146His Uncertain significance Single submitter
- DPCD p.Asp32Glu Uncertain significance Single submitter
- DPCD p.Asp41Asn Uncertain significance Single submitter
- DPCD p.Leu109Ile Uncertain significance Single submitter
- DPCD p.Leu157Met Uncertain significance Single submitter
- DPCD p.Lys99Asn Uncertain significance Single submitter
- DPCD p.Thr44Met Uncertain significance Single submitter
- DPCD p.Tyr116Cys Uncertain significance Single submitter
- DPCD p.Val118Ala Uncertain significance Single submitter
- DPCD p.Thr4Met Uncertain significance No assertion criteria
All DPCD variants
Benign 1
- p.Leu156Ser Multiple submitters ⚠
Likely benign 1
- p.Ile127Val Single submitter
Uncertain significance 30
- p.Ala155Pro Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala89Gly Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Arg105Trp Single submitter ⚠
- p.Arg125Cys Single submitter ⚠
- p.Arg125His Single submitter ⚠
- p.Arg53Ser Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asp146His Single submitter ⚠
- p.Asp197Gly Single submitter ⚠
- p.Asp21Glu Single submitter ⚠
- p.Asp32Glu Single submitter ⚠
- p.Asp41Asn Single submitter ⚠
- p.Gly198Glu Single submitter ⚠
- p.Gly75Glu Single submitter ⚠
- p.Gly80Glu Single submitter ⚠
- p.Leu109Ile Single submitter ⚠
- p.Leu157Met Single submitter ⚠
- p.Leu18Pro Single submitter ⚠
- p.Lys135Gln Single submitter ⚠
- p.Lys99Asn Single submitter ⚠
- p.Thr131Pro Single submitter ⚠
- p.Thr44Met Single submitter ⚠
- p.Trp6Cys Single submitter ⚠
- p.Tyr116Cys Single submitter ⚠
- p.Tyr137His Single submitter ⚠
- p.Val118Ala Single submitter ⚠
- p.Thr4Met No assertion criteria ⚠