DPEP1 — 51 ClinVar variants
All ClinVar germline DPEP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
1 Likely benign · 50 Uncertain significance
Full DPEP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPEP1 p.Ala155Glu Uncertain significance Single submitter
- DPEP1 p.Ala155Thr Uncertain significance Single submitter
- DPEP1 p.Ala296Val Uncertain significance Single submitter
- DPEP1 p.Arg107Leu Uncertain significance Single submitter
- DPEP1 p.Arg245Gln Uncertain significance Single submitter
- DPEP1 p.Arg246Cys Uncertain significance Single submitter
- DPEP1 p.Arg392Cys Uncertain significance Single submitter
- DPEP1 p.Asp317Tyr Uncertain significance Single submitter
- DPEP1 p.Asp371Glu Uncertain significance Single submitter
- DPEP1 p.Cys14Gly Uncertain significance Single submitter
- DPEP1 p.Glu337Gly Uncertain significance Single submitter
- DPEP1 p.Gly4Ala Uncertain significance Single submitter
- DPEP1 p.Gly74Ser Uncertain significance Single submitter
- DPEP1 p.His235Arg Uncertain significance Single submitter
- DPEP1 p.Leu410His Uncertain significance Single submitter
- DPEP1 p.Met108Leu Uncertain significance Single submitter
- DPEP1 p.Pro187Leu Uncertain significance Single submitter
- DPEP1 p.Ser234Gly Uncertain significance Single submitter
- DPEP1 p.Ser237Pro Uncertain significance Single submitter
- DPEP1 p.Thr275Ala Uncertain significance Single submitter
- DPEP1 p.Trp81Gly Uncertain significance Single submitter
- DPEP1 p.Val283Met Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- DPEP1 p.Ala326Thr Uncertain significance Single submitter
- DPEP1 p.Ala402Asp Uncertain significance Single submitter
- DPEP1 p.Arg110Trp Uncertain significance Single submitter
- DPEP1 p.Arg126Gln Uncertain significance Single submitter
- DPEP1 p.Arg126Gly Uncertain significance Single submitter
- DPEP1 p.Arg126Trp Uncertain significance Single submitter
- DPEP1 p.Arg205Cys Uncertain significance Single submitter
- DPEP1 p.Arg55Thr Uncertain significance Single submitter
- DPEP1 p.Asn266Ser Uncertain significance Single submitter
- DPEP1 p.Asp323Tyr Uncertain significance Single submitter
- DPEP1 p.Asp344Tyr Uncertain significance Single submitter
- DPEP1 p.Gln52Lys Uncertain significance Single submitter
- DPEP1 p.Glu313Val Uncertain significance Single submitter
- DPEP1 p.Glu364Asp Uncertain significance Single submitter
- DPEP1 p.Lys291Asn Uncertain significance Single submitter
- DPEP1 p.Pro173Arg Uncertain significance Single submitter
- DPEP1 p.Pro31His Uncertain significance Single submitter
- DPEP1 p.Pro86Ser Uncertain significance Single submitter
- DPEP1 p.Ser193Leu Uncertain significance Single submitter
- DPEP1 p.Ser281Phe Uncertain significance Single submitter
- DPEP1 p.Thr334Met Uncertain significance Single submitter
- DPEP1 p.Trp6Gly Uncertain significance Single submitter
- DPEP1 p.Tyr112Asn Uncertain significance Single submitter
- DPEP1 p.Val200Met Uncertain significance Single submitter
- DPEP1 p.Val217Leu Uncertain significance Single submitter
- DPEP1 p.Val248Leu Uncertain significance Single submitter
- DPEP1 p.Val252Ile Uncertain significance Single submitter
- DPEP1 p.Val318Ile Uncertain significance Single submitter
All DPEP1 variants
Likely benign 1
- p.Arg110Gln Single submitter
Uncertain significance 50
- p.Ala155Glu Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala296Val Single submitter ⚠
- p.Ala326Thr Single submitter ⚠
- p.Ala402Asp Single submitter ⚠
- p.Arg107Leu Single submitter ⚠
- p.Arg110Trp Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg126Gly Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Arg245Gln Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg392Cys Single submitter ⚠
- p.Arg55Thr Single submitter ⚠
- p.Asn266Ser Single submitter ⚠
- p.Asp317Tyr Single submitter ⚠
- p.Asp323Tyr Single submitter ⚠
- p.Asp344Tyr Single submitter ⚠
- p.Asp371Glu Single submitter ⚠
- p.Cys14Gly Single submitter ⚠
- p.Gln52Lys Single submitter ⚠
- p.Glu313Val Single submitter ⚠
- p.Glu337Gly Single submitter ⚠
- p.Glu364Asp Single submitter ⚠
- p.Gly4Ala Single submitter ⚠
- p.Gly74Ser Single submitter ⚠
- p.His235Arg Single submitter ⚠
- p.Leu410His Single submitter ⚠
- p.Lys291Asn Single submitter ⚠
- p.Met108Leu Single submitter ⚠
- p.Pro173Arg Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro31His Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser193Leu Single submitter ⚠
- p.Ser234Gly Single submitter ⚠
- p.Ser237Pro Single submitter ⚠
- p.Ser281Phe Single submitter ⚠
- p.Thr275Ala Single submitter ⚠
- p.Thr334Met Single submitter ⚠
- p.Trp6Gly Single submitter ⚠
- p.Trp81Gly Single submitter ⚠
- p.Tyr112Asn Single submitter ⚠
- p.Val200Met Single submitter ⚠
- p.Val217Leu Single submitter ⚠
- p.Val248Leu Single submitter ⚠
- p.Val252Ile Single submitter ⚠
- p.Val283Met Single submitter ⚠
- p.Val318Ile Single submitter ⚠