DPEP2 — 82 ClinVar variants
All ClinVar germline DPEP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
6 Likely benign · 76 Uncertain significance
Full DPEP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPEP2 p.Ala226Thr Uncertain significance Single submitter
- DPEP2 p.Ala33Thr Uncertain significance Single submitter
- DPEP2 p.Ala59Thr Uncertain significance Single submitter
- DPEP2 p.Arg390Gly Uncertain significance Single submitter
- DPEP2 p.Asp241Glu Uncertain significance Single submitter
- DPEP2 p.Asp429Asn Uncertain significance Single submitter
- DPEP2 p.Asp87Glu Uncertain significance Single submitter
- DPEP2 p.Gln301Lys Uncertain significance Single submitter
- DPEP2 p.Gln399Glu Uncertain significance Single submitter
- DPEP2 p.Gly13Ala Uncertain significance Single submitter
- DPEP2 p.Gly349Asp Uncertain significance Single submitter
- DPEP2 p.Ile199Thr Uncertain significance Single submitter
- DPEP2 p.Leu413Phe Uncertain significance Single submitter
- DPEP2 p.Leu85His Uncertain significance Single submitter
- DPEP2 p.Leu92Pro Uncertain significance Single submitter
- DPEP2 p.Lys408Gln Uncertain significance Single submitter
- DPEP2 p.Met205Ile Uncertain significance Single submitter
- DPEP2 p.Met256Thr Uncertain significance Single submitter
- DPEP2 p.Met469Thr Uncertain significance Single submitter
- DPEP2 p.Pro16Leu Uncertain significance Single submitter
- DPEP2 p.Pro39Leu Uncertain significance Single submitter
- DPEP2 p.Pro39Ser Uncertain significance Single submitter
- DPEP2 p.Pro67Leu Uncertain significance Single submitter
- DPEP2 p.Ser19Gly Uncertain significance Single submitter
- DPEP2 p.Ser428Pro Uncertain significance Single submitter
- DPEP2 p.Ser466Pro Uncertain significance Single submitter
- DPEP2 p.Thr212Arg Uncertain significance Single submitter
- DPEP2 p.Thr57Ala Uncertain significance Single submitter
- DPEP2 p.Thr62Ala Uncertain significance Single submitter
- DPEP2 p.Trp221Cys Uncertain significance Single submitter
- DPEP2 p.Val278Glu Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- DPEP2 p.Ala276Thr Uncertain significance Single submitter
- DPEP2 p.Ala78Val Uncertain significance Single submitter
- DPEP2 p.Arg147Cys Uncertain significance Single submitter
- DPEP2 p.Arg147His Uncertain significance Single submitter
- DPEP2 p.Arg158Cys Uncertain significance Single submitter
- DPEP2 p.Arg158His Uncertain significance Single submitter
- DPEP2 p.Arg209Cys Uncertain significance Single submitter
- DPEP2 p.Arg268Gln Uncertain significance Single submitter
- DPEP2 p.Arg268Trp Uncertain significance Single submitter
- DPEP2 p.Arg286Trp Uncertain significance Single submitter
- DPEP2 p.Arg293Trp Uncertain significance Single submitter
- DPEP2 p.Arg395Gln Uncertain significance Single submitter
- DPEP2 p.Arg41Thr Uncertain significance Single submitter
- DPEP2 p.Arg434Cys Uncertain significance Single submitter
- DPEP2 p.Arg77Gln Uncertain significance Single submitter
- DPEP2 p.Asp298Tyr Uncertain significance Single submitter
- DPEP2 p.Gln320Pro Uncertain significance Single submitter
- DPEP2 p.Gln386His Uncertain significance Single submitter
- DPEP2 p.Glu151Lys Uncertain significance Single submitter
- DPEP2 p.Glu223Lys Uncertain significance Single submitter
- DPEP2 p.Glu272Lys Uncertain significance Single submitter
- DPEP2 p.Glu383Asp Uncertain significance Single submitter
- DPEP2 p.Glu383Gly Uncertain significance Single submitter
- DPEP2 p.Glu405Lys Uncertain significance Single submitter
- DPEP2 p.Gly238Arg Uncertain significance Single submitter
- DPEP2 p.Gly47Ser Uncertain significance Single submitter
- DPEP2 p.Leu126Val Uncertain significance Single submitter
- DPEP2 p.Leu21Pro Uncertain significance Single submitter
- DPEP2 p.Leu433Pro Uncertain significance Single submitter
- DPEP2 p.Leu64Phe Uncertain significance Single submitter
- DPEP2 p.Leu85Pro Uncertain significance Single submitter
- DPEP2 p.Pro40Ala Uncertain significance Single submitter
- DPEP2 p.Pro418Leu Uncertain significance Single submitter
- DPEP2 p.Ser283Leu Uncertain significance Single submitter
- DPEP2 p.Ser425Phe Uncertain significance Single submitter
- DPEP2 p.Ser431Leu Uncertain significance Single submitter
- DPEP2 p.Thr212Met Uncertain significance Single submitter
- DPEP2 p.Thr35Ser Uncertain significance Single submitter
- DPEP2 p.Thr36Lys Uncertain significance Single submitter
- DPEP2 p.Thr53Ser Uncertain significance Single submitter
- DPEP2 p.Val257Ile Uncertain significance Single submitter
- DPEP2 p.Val273Met Uncertain significance Single submitter
- DPEP2 p.Val340Ile Uncertain significance Single submitter
- DPEP2 p.Val365Met Uncertain significance Single submitter
- DPEP2 p.Val388Ile Uncertain significance Single submitter
All DPEP2 variants
Likely benign 6
- p.Arg157His Single submitter
- p.Arg432His Single submitter
- p.Gln410Arg Single submitter
- p.Gly442Asp Single submitter
- p.Ser65Gly Single submitter
- p.Thr170= Single submitter
Uncertain significance 76
- p.Ala226Thr Single submitter ⚠
- p.Ala276Thr Single submitter ⚠
- p.Ala33Thr Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Ala78Val Single submitter ⚠
- p.Arg147Cys Single submitter ⚠
- p.Arg147His Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg268Gln Single submitter ⚠
- p.Arg268Trp Single submitter ⚠
- p.Arg286Trp Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg390Gly Single submitter ⚠
- p.Arg395Gln Single submitter ⚠
- p.Arg41Thr Single submitter ⚠
- p.Arg434Cys Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Asp241Glu Single submitter ⚠
- p.Asp298Tyr Single submitter ⚠
- p.Asp429Asn Single submitter ⚠
- p.Asp87Glu Single submitter ⚠
- p.Gln301Lys Single submitter ⚠
- p.Gln320Pro Single submitter ⚠
- p.Gln386His Single submitter ⚠
- p.Gln399Glu Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu272Lys Single submitter ⚠
- p.Glu383Asp Single submitter ⚠
- p.Glu383Gly Single submitter ⚠
- p.Glu405Lys Single submitter ⚠
- p.Gly13Ala Single submitter ⚠
- p.Gly238Arg Single submitter ⚠
- p.Gly349Asp Single submitter ⚠
- p.Gly47Ser Single submitter ⚠
- p.Ile199Thr Single submitter ⚠
- p.Leu126Val Single submitter ⚠
- p.Leu21Pro Single submitter ⚠
- p.Leu413Phe Single submitter ⚠
- p.Leu433Pro Single submitter ⚠
- p.Leu64Phe Single submitter ⚠
- p.Leu85His Single submitter ⚠
- p.Leu85Pro Single submitter ⚠
- p.Leu92Pro Single submitter ⚠
- p.Lys408Gln Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met256Thr Single submitter ⚠
- p.Met469Thr Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Pro40Ala Single submitter ⚠
- p.Pro418Leu Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Ser19Gly Single submitter ⚠
- p.Ser283Leu Single submitter ⚠
- p.Ser425Phe Single submitter ⚠
- p.Ser428Pro Single submitter ⚠
- p.Ser431Leu Single submitter ⚠
- p.Ser466Pro Single submitter ⚠
- p.Thr212Arg Single submitter ⚠
- p.Thr212Met Single submitter ⚠
- p.Thr35Ser Single submitter ⚠
- p.Thr36Lys Single submitter ⚠
- p.Thr53Ser Single submitter ⚠
- p.Thr57Ala Single submitter ⚠
- p.Thr62Ala Single submitter ⚠
- p.Trp221Cys Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val273Met Single submitter ⚠
- p.Val278Glu Single submitter ⚠
- p.Val340Ile Single submitter ⚠
- p.Val365Met Single submitter ⚠
- p.Val388Ile Single submitter ⚠