DPEP3 — 65 ClinVar variants
All ClinVar germline DPEP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign · 4 Likely benign · 60 Uncertain significance
Full DPEP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPEP3 p.Arg217Pro Uncertain significance Single submitter
- DPEP3 p.Arg30Trp Uncertain significance Single submitter
- DPEP3 p.Asn98Asp Uncertain significance Single submitter
- DPEP3 p.Asp114His Uncertain significance Single submitter
- DPEP3 p.Asp128His Uncertain significance Single submitter
- DPEP3 p.Gln147Glu Uncertain significance Single submitter
- DPEP3 p.Gln454Glu Uncertain significance Single submitter
- DPEP3 p.Glu424Val Uncertain significance Single submitter
- DPEP3 p.Gly198Arg Uncertain significance Single submitter
- DPEP3 p.Gly251Arg Uncertain significance Single submitter
- DPEP3 p.His238Tyr Uncertain significance Single submitter
- DPEP3 p.Leu192Pro Uncertain significance Single submitter
- DPEP3 p.Leu214Pro Uncertain significance Single submitter
- DPEP3 p.Leu331Pro Uncertain significance Single submitter
- DPEP3 p.Lys109Asn Uncertain significance Single submitter
- DPEP3 p.Met263Val Uncertain significance Single submitter
- DPEP3 p.Met319Ile Uncertain significance Single submitter
- DPEP3 p.Pro228Ser Uncertain significance Single submitter
- DPEP3 p.Ser271Trp Uncertain significance Single submitter
- DPEP3 p.Ser419Gly Uncertain significance Single submitter
- DPEP3 p.Ser431Arg Uncertain significance Single submitter
- DPEP3 p.Trp229Arg Uncertain significance Single submitter
- DPEP3 p.Val195Met Uncertain significance Single submitter
- DPEP3 p.Val326Leu Uncertain significance Single submitter
- DPEP3 p.Val439Met Uncertain significance Single submitter
- DPEP3 p.Val94Glu Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- DPEP3 p.Ala11Thr Uncertain significance Single submitter
- DPEP3 p.Ala157Pro Uncertain significance Single submitter
- DPEP3 p.Ala284Gly Uncertain significance Single submitter
- DPEP3 p.Arg166Cys Uncertain significance Single submitter
- DPEP3 p.Arg19His Uncertain significance Single submitter
- DPEP3 p.Arg209His Uncertain significance Single submitter
- DPEP3 p.Arg386Cys Uncertain significance Single submitter
- DPEP3 p.Arg386His Uncertain significance Single submitter
- DPEP3 p.Arg403Trp Uncertain significance Single submitter
- DPEP3 p.Asn98Ser Uncertain significance Single submitter
- DPEP3 p.Asp272Gly Uncertain significance Single submitter
- DPEP3 p.Gln102Arg Uncertain significance Single submitter
- DPEP3 p.Gln394His Uncertain significance Single submitter
- DPEP3 p.Glu280Asp Uncertain significance Single submitter
- DPEP3 p.Glu382Gln Uncertain significance Single submitter
- DPEP3 p.Gly246Arg Uncertain significance Single submitter
- DPEP3 p.His199Gln Uncertain significance Single submitter
- DPEP3 p.His97Tyr Uncertain significance Single submitter
- DPEP3 p.Ile193Leu Uncertain significance Single submitter
- DPEP3 p.Ile317Asn Uncertain significance Single submitter
- DPEP3 p.Leu163Phe Uncertain significance Single submitter
- DPEP3 p.Leu24Val Uncertain significance Single submitter
- DPEP3 p.Lys313Asn Uncertain significance Single submitter
- DPEP3 p.Ser145Thr Uncertain significance Single submitter
- DPEP3 p.Thr34Ile Uncertain significance Single submitter
- DPEP3 p.Thr70Ala Uncertain significance Single submitter
- DPEP3 p.Tyr212Phe Uncertain significance Single submitter
- DPEP3 p.Val135Met Uncertain significance Single submitter
- DPEP3 p.Val318Met Uncertain significance Single submitter
All DPEP3 variants
Benign 1
- p.Ser121= Single submitter
Likely benign 4
- c.-69C>G Single submitter
- p.Arg458Gln Single submitter
- p.Asn457Ser Single submitter
- p.Ser13Gly Single submitter
Uncertain significance 60
- c.-44A>T Single submitter
- c.-47C>G Single submitter
- c.-5G>T Single submitter
- c.-62C>T Single submitter
- c.-6C>T Single submitter
- p.Ala11Thr Single submitter ⚠
- p.Ala157Pro Single submitter ⚠
- p.Ala284Gly Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Arg19His Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg217Pro Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg386His Single submitter ⚠
- p.Arg403Trp Single submitter ⚠
- p.Asn98Asp Single submitter ⚠
- p.Asn98Ser Single submitter ⚠
- p.Asp114His Single submitter ⚠
- p.Asp128His Single submitter ⚠
- p.Asp272Gly Single submitter ⚠
- p.Gln102Arg Single submitter ⚠
- p.Gln147Glu Single submitter ⚠
- p.Gln394His Single submitter ⚠
- p.Gln454Glu Single submitter ⚠
- p.Glu280Asp Single submitter ⚠
- p.Glu382Gln Single submitter ⚠
- p.Glu424Val Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.Gly251Arg Single submitter ⚠
- p.His199Gln Single submitter ⚠
- p.His238Tyr Single submitter ⚠
- p.His97Tyr Single submitter ⚠
- p.Ile193Leu Single submitter ⚠
- p.Ile317Asn Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Leu192Pro Single submitter ⚠
- p.Leu214Pro Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Leu331Pro Single submitter ⚠
- p.Lys109Asn Single submitter ⚠
- p.Lys313Asn Single submitter ⚠
- p.Met263Val Single submitter ⚠
- p.Met319Ile Single submitter ⚠
- p.Pro228Ser Single submitter ⚠
- p.Ser145Thr Single submitter ⚠
- p.Ser271Trp Single submitter ⚠
- p.Ser419Gly Single submitter ⚠
- p.Ser431Arg Single submitter ⚠
- p.Thr34Ile Single submitter ⚠
- p.Thr70Ala Single submitter ⚠
- p.Trp229Arg Single submitter ⚠
- p.Tyr212Phe Single submitter ⚠
- p.Val135Met Single submitter ⚠
- p.Val195Met Single submitter ⚠
- p.Val318Met Single submitter ⚠
- p.Val326Leu Single submitter ⚠
- p.Val439Met Single submitter ⚠
- p.Val94Glu Single submitter ⚠