Sugi Variant

Sugi Variant/DPF2

DPF2 — 258 ClinVar variants

All ClinVar germline DPF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →

8 Pathogenic · 11 Likely pathogenic · 13 Conflicting · 12 Benign · 3 Benign/Likely benign · 105 Likely benign · 106 Uncertain significance

Full DPF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 108

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 9

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 69

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All DPF2 variants

Pathogenic 8

Likely pathogenic 11

Conflicting classifications of pathogenicity 13

Benign 12

Benign/Likely benign 3

Likely benign 105

Uncertain significance 106