DPF3 — 59 ClinVar variants
All ClinVar germline DPF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
2 Benign · 57 Uncertain significance
Full DPF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPF3 p.Ala189Thr Uncertain significance Single submitter
- DPF3 p.Ala189Val Uncertain significance Single submitter
- DPF3 p.Ala76Val Uncertain significance Single submitter
- DPF3 p.Arg171Thr Uncertain significance Single submitter
- DPF3 p.Arg175Trp Uncertain significance Single submitter
- DPF3 p.Arg177Cys Uncertain significance Single submitter
- DPF3 p.Arg25Trp Uncertain significance Single submitter
- DPF3 p.Arg30Gln Uncertain significance Single submitter
- DPF3 p.Arg62Gln Uncertain significance Single submitter
- DPF3 p.Arg80Cys Uncertain significance Single submitter
- DPF3 p.Arg84Gln Uncertain significance Single submitter
- DPF3 p.Asn260Lys Uncertain significance Single submitter
- DPF3 p.Asn270Ser Uncertain significance Single submitter
- DPF3 p.Asn52Asp Uncertain significance Single submitter
- DPF3 p.Asp14Asn Uncertain significance Single submitter
- DPF3 p.Asp187Asn Uncertain significance Single submitter
- DPF3 p.Cys78Trp Uncertain significance Single submitter
- DPF3 p.Gln233His Uncertain significance Single submitter
- DPF3 p.Glu125Lys Uncertain significance Single submitter
- DPF3 p.Glu226Val Uncertain significance Single submitter
- DPF3 p.Glu234Gly Uncertain significance Single submitter
- DPF3 p.Gly178Ser Uncertain significance Single submitter
- DPF3 p.His194Gln Uncertain significance Single submitter
- DPF3 p.His61Arg Uncertain significance Single submitter
- DPF3 p.Ile142Met Uncertain significance Single submitter
- DPF3 p.Met271Leu Uncertain significance Single submitter
- DPF3 p.Phe16Leu Uncertain significance Single submitter
- DPF3 p.Pro197Ser Uncertain significance Single submitter
- DPF3 p.Pro238Ser Uncertain significance Single submitter
- DPF3 p.Pro75Ser Uncertain significance Single submitter
- DPF3 p.Ser26Arg Uncertain significance Single submitter
- DPF3 p.Tyr72Cys Uncertain significance Single submitter
- DPF3 p.Val145Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DPF3 p.Ala285Thr Uncertain significance Single submitter
- DPF3 p.Arg123Cys Uncertain significance Single submitter
- DPF3 p.Arg123His Uncertain significance Single submitter
- DPF3 p.Arg175Gln Uncertain significance Single submitter
- DPF3 p.Arg184Lys Uncertain significance Single submitter
- DPF3 p.Arg277Trp Uncertain significance Single submitter
- DPF3 p.Asp164Asn Uncertain significance Single submitter
- DPF3 p.Asp193Glu Uncertain significance Single submitter
- DPF3 p.Asp90Val Uncertain significance Single submitter
- DPF3 p.Glu225Lys Uncertain significance Single submitter
- DPF3 p.Pro252Leu Uncertain significance Single submitter
- DPF3 p.Pro8Thr Uncertain significance Single submitter
- DPF3 p.Pro91Ala Uncertain significance Single submitter
- DPF3 p.Thr117Lys Uncertain significance Single submitter
- DPF3 p.Val37Met Uncertain significance Single submitter
All DPF3 variants
Benign 2
- p.Leu85= Multiple submitters
- c.32+1737G>A Single submitter
Uncertain significance 57
- c.871+2959C>T Multiple submitters
- c.871+2937G>T Single submitter
- c.871+2946G>A Single submitter
- c.871+2953G>A Single submitter
- c.871+2958A>G Single submitter
- c.871+3006C>T Single submitter
- c.871+3020G>C Single submitter
- c.871+3078A>G Single submitter
- c.871+3097G>A Single submitter
- p.Ala189Thr Single submitter ⚠
- p.Ala189Val Single submitter ⚠
- p.Ala285Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg171Thr Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg177Cys Single submitter ⚠
- p.Arg184Lys Single submitter ⚠
- p.Arg25Trp Single submitter ⚠
- p.Arg277Trp Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Asn260Lys Single submitter ⚠
- p.Asn270Ser Single submitter ⚠
- p.Asn52Asp Single submitter ⚠
- p.Asp14Asn Single submitter ⚠
- p.Asp164Asn Single submitter ⚠
- p.Asp187Asn Single submitter ⚠
- p.Asp193Glu Single submitter ⚠
- p.Asp90Val Single submitter ⚠
- p.Cys78Trp Single submitter ⚠
- p.Gln233His Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Glu225Lys Single submitter ⚠
- p.Glu226Val Single submitter ⚠
- p.Glu234Gly Single submitter ⚠
- p.Gly178Ser Single submitter ⚠
- p.His194Gln Single submitter ⚠
- p.His61Arg Single submitter ⚠
- p.Ile142Met Single submitter ⚠
- p.Met271Leu Single submitter ⚠
- p.Phe16Leu Single submitter ⚠
- p.Pro197Ser Single submitter ⚠
- p.Pro238Ser Single submitter ⚠
- p.Pro252Leu Single submitter ⚠
- p.Pro75Ser Single submitter ⚠
- p.Pro8Thr Single submitter ⚠
- p.Pro91Ala Single submitter ⚠
- p.Ser26Arg Single submitter ⚠
- p.Thr117Lys Single submitter ⚠
- p.Tyr72Cys Single submitter ⚠
- p.Val145Ile Single submitter ⚠
- p.Val37Met Single submitter ⚠