DPH3 — 12 ClinVar variants
All ClinVar germline DPH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
12 Uncertain significance
Full DPH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPH3 p.Asp12Ala Uncertain significance Single submitter
- DPH3 p.Asp62Asn Uncertain significance Single submitter
- DPH3 p.Cys28Arg Uncertain significance Single submitter
- DPH3 p.Cys51Ser Uncertain significance Single submitter
- DPH3 p.Lys36Arg Uncertain significance Single submitter
- DPH3 p.Pro25Leu Uncertain significance Single submitter
- DPH3 p.Thr21Ser Uncertain significance Single submitter
- DPH3 p.Thr47Lys Uncertain significance Single submitter
- DPH3 p.Tyr59Cys Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DPH3 variants
Uncertain significance 12
- p.Asp12Ala Single submitter ⚠
- p.Asp18Gly Single submitter ⚠
- p.Asp62Asn Single submitter ⚠
- p.Cys28Arg Single submitter ⚠
- p.Cys51Ser Single submitter ⚠
- p.Lys36Arg Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Thr21Ser Single submitter ⚠
- p.Thr47Lys Single submitter ⚠
- p.Thr69Arg Single submitter ⚠
- p.Tyr24Cys Single submitter ⚠
- p.Tyr59Cys Single submitter ⚠