DPH7 — 89 ClinVar variants
All ClinVar germline DPH7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
4 Likely benign · 85 Uncertain significance
Full DPH7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPH7 p.Ala198Pro Uncertain significance Single submitter
- DPH7 p.Ala427Thr Uncertain significance Single submitter
- DPH7 p.Arg381Lys Uncertain significance Single submitter
- DPH7 p.Asn50Lys Uncertain significance Single submitter
- DPH7 p.Asp11Gly Uncertain significance Single submitter
- DPH7 p.Asp159His Uncertain significance Single submitter
- DPH7 p.Asp17Glu Uncertain significance Single submitter
- DPH7 p.Asp216Asn Uncertain significance Single submitter
- DPH7 p.Asp216Gly Uncertain significance Single submitter
- DPH7 p.Asp385Asn Uncertain significance Single submitter
- DPH7 p.Asp419Gly Uncertain significance Single submitter
- DPH7 p.Gln282Glu Uncertain significance Single submitter
- DPH7 p.Gln393Arg Uncertain significance Single submitter
- DPH7 p.Gln84His Uncertain significance Single submitter
- DPH7 p.Glu372Lys Uncertain significance Single submitter
- DPH7 p.Gly152Glu Uncertain significance Single submitter
- DPH7 p.Gly171Ala Uncertain significance Single submitter
- DPH7 p.Gly215Cys Uncertain significance Single submitter
- DPH7 p.Gly386Glu Uncertain significance Single submitter
- DPH7 p.Gly421Ser Uncertain significance Single submitter
- DPH7 p.His104Arg Uncertain significance Single submitter
- DPH7 p.His295Asn Uncertain significance Single submitter
- DPH7 p.His98Pro Uncertain significance Single submitter
- DPH7 p.Ile77Met Uncertain significance Single submitter
- DPH7 p.Ile77Val Uncertain significance Single submitter
- DPH7 p.Ile99Leu Uncertain significance Single submitter
- DPH7 p.Leu298Phe Uncertain significance Single submitter
- DPH7 p.Leu360Val Uncertain significance Single submitter
- DPH7 p.Leu367Pro Uncertain significance Single submitter
- DPH7 p.Leu410Pro Uncertain significance Single submitter
- DPH7 p.Leu433Arg Uncertain significance Single submitter
- DPH7 p.Leu444Pro Uncertain significance Single submitter
- DPH7 p.Met403Thr Uncertain significance Single submitter
- DPH7 p.Pro23Arg Uncertain significance Single submitter
- DPH7 p.Pro376Ser Uncertain significance Single submitter
- DPH7 p.Pro398Ser Uncertain significance Single submitter
- DPH7 p.Ser150Phe Uncertain significance Single submitter
- DPH7 p.Ser150Tyr Uncertain significance Single submitter
- DPH7 p.Ser353Leu Uncertain significance Single submitter
- DPH7 p.Ser438Phe Uncertain significance Single submitter
- DPH7 p.Thr408Pro Uncertain significance Single submitter
- DPH7 p.Trp342Arg Uncertain significance Single submitter
- DPH7 p.Tyr260Cys Uncertain significance Single submitter
- DPH7 p.Tyr336Cys Uncertain significance Single submitter
- DPH7 p.Val422Met Uncertain significance Single submitter
- DPH7 p.Val56Asp Uncertain significance Single submitter
- DPH7 p.Val81Phe Uncertain significance Single submitter
-
DPH7 p.Asn311Ser
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 38
The independent predictors disagree with each other — read with care.
- DPH7 p.Ala105Thr Uncertain significance Single submitter
- DPH7 p.Ala16Thr Uncertain significance Single submitter
- DPH7 p.Ala193Val Uncertain significance Single submitter
- DPH7 p.Ala198Thr Uncertain significance Single submitter
- DPH7 p.Ala198Val Uncertain significance Single submitter
- DPH7 p.Arg237Ser Uncertain significance Single submitter
- DPH7 p.Arg270Gln Uncertain significance Single submitter
- DPH7 p.Arg346Cys Uncertain significance Single submitter
- DPH7 p.Arg40Trp Uncertain significance Single submitter
- DPH7 p.Arg44Pro Likely benign Single submitter
- DPH7 p.Arg62His Uncertain significance Single submitter
- DPH7 p.Arg65His Uncertain significance Single submitter
- DPH7 p.Asp339Glu Uncertain significance Single submitter
- DPH7 p.Asp43Ala Uncertain significance Single submitter
- DPH7 p.Asp87Ala Uncertain significance Single submitter
- DPH7 p.Cys302Ser Uncertain significance Single submitter
- DPH7 p.Gln246His Uncertain significance Single submitter
- DPH7 p.Gln282Arg Uncertain significance Single submitter
- DPH7 p.Gln313Arg Uncertain significance Single submitter
- DPH7 p.Glu82Ala Uncertain significance Single submitter
- DPH7 p.His253Arg Uncertain significance Single submitter
- DPH7 p.His29Arg Uncertain significance Single submitter
- DPH7 p.His29Gln Uncertain significance Single submitter
- DPH7 p.Leu255Val Uncertain significance Single submitter
- DPH7 p.Leu297Gln Uncertain significance Single submitter
- DPH7 p.Met240Leu Uncertain significance Single submitter
- DPH7 p.Phe71Leu Uncertain significance Single submitter
- DPH7 p.Pro100Leu Uncertain significance Single submitter
- DPH7 p.Pro161Leu Uncertain significance Single submitter
- DPH7 p.Pro41Ser Uncertain significance Single submitter
- DPH7 p.Ser127Asn Uncertain significance Single submitter
- DPH7 p.Ser135Ile Uncertain significance Single submitter
- DPH7 p.Ser327Phe Uncertain significance Single submitter
- DPH7 p.Ser355Phe Uncertain significance Single submitter
- DPH7 p.Thr151Ile Uncertain significance Single submitter
- DPH7 p.Thr279Lys Uncertain significance Single submitter
- DPH7 p.Thr279Met Uncertain significance Single submitter
- DPH7 p.Tyr440Cys Uncertain significance Single submitter
All DPH7 variants
Likely benign 4
- p.Ala443Val Single submitter
- p.Arg418Cys Single submitter
- p.Arg44Pro Single submitter ⚠
- p.Asp428Asn Single submitter
Uncertain significance 85
- p.Ala105Thr Single submitter ⚠
- p.Ala16Thr Single submitter ⚠
- p.Ala193Val Single submitter ⚠
- p.Ala198Pro Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala198Val Single submitter ⚠
- p.Ala427Thr Single submitter ⚠
- p.Arg237Ser Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg346Cys Single submitter ⚠
- p.Arg381Lys Single submitter ⚠
- p.Arg40Trp Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Arg65His Single submitter ⚠
- p.Asn50Lys Single submitter ⚠
- p.Asp11Gly Single submitter ⚠
- p.Asp159His Single submitter ⚠
- p.Asp17Glu Single submitter ⚠
- p.Asp216Asn Single submitter ⚠
- p.Asp216Gly Single submitter ⚠
- p.Asp339Glu Single submitter ⚠
- p.Asp385Asn Single submitter ⚠
- p.Asp419Gly Single submitter ⚠
- p.Asp43Ala Single submitter ⚠
- p.Asp87Ala Single submitter ⚠
- p.Cys302Ser Single submitter ⚠
- p.Gln246His Single submitter ⚠
- p.Gln282Arg Single submitter ⚠
- p.Gln282Glu Single submitter ⚠
- p.Gln313Arg Single submitter ⚠
- p.Gln393Arg Single submitter ⚠
- p.Gln84His Single submitter ⚠
- p.Glu372Lys Single submitter ⚠
- p.Glu82Ala Single submitter ⚠
- p.Gly152Glu Single submitter ⚠
- p.Gly171Ala Single submitter ⚠
- p.Gly215Cys Single submitter ⚠
- p.Gly386Glu Single submitter ⚠
- p.Gly421Ser Single submitter ⚠
- p.His104Arg Single submitter ⚠
- p.His253Arg Single submitter ⚠
- p.His295Asn Single submitter ⚠
- p.His29Arg Single submitter ⚠
- p.His29Gln Single submitter ⚠
- p.His98Pro Single submitter ⚠
- p.Ile77Met Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Ile99Leu Single submitter ⚠
- p.Leu255Val Single submitter ⚠
- p.Leu297Gln Single submitter ⚠
- p.Leu298Phe Single submitter ⚠
- p.Leu360Val Single submitter ⚠
- p.Leu367Pro Single submitter ⚠
- p.Leu410Pro Single submitter ⚠
- p.Leu433Arg Single submitter ⚠
- p.Leu444Pro Single submitter ⚠
- p.Met240Leu Single submitter ⚠
- p.Met403Thr Single submitter ⚠
- p.Phe71Leu Single submitter ⚠
- p.Pro100Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro23Arg Single submitter ⚠
- p.Pro376Ser Single submitter ⚠
- p.Pro398Ser Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Ser127Asn Single submitter ⚠
- p.Ser135Ile Single submitter ⚠
- p.Ser150Phe Single submitter ⚠
- p.Ser150Tyr Single submitter ⚠
- p.Ser327Phe Single submitter ⚠
- p.Ser353Leu Single submitter ⚠
- p.Ser355Phe Single submitter ⚠
- p.Ser438Phe Single submitter ⚠
- p.Thr151Ile Single submitter ⚠
- p.Thr279Lys Single submitter ⚠
- p.Thr279Met Single submitter ⚠
- p.Thr408Pro Single submitter ⚠
- p.Trp342Arg Single submitter ⚠
- p.Tyr260Cys Single submitter ⚠
- p.Tyr336Cys Single submitter ⚠
- p.Tyr440Cys Single submitter ⚠
- p.Val422Met Single submitter ⚠
- p.Val56Asp Single submitter ⚠
- p.Val81Phe Single submitter ⚠
- p.Asn311Ser No assertion criteria prostate cancer ⚠