DPP3 — 146 ClinVar variants
All ClinVar germline DPP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →
1 Conflicting · 10 Benign · 1 Likely benign · 134 Uncertain significance
Full DPP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 137
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPP3 p.Ala252Thr Uncertain significance Single submitter
- DPP3 p.Ala382Pro Uncertain significance Single submitter
- DPP3 p.Ala91Val Uncertain significance Single submitter
- DPP3 p.Arg20His Uncertain significance Single submitter
- DPP3 p.Arg510Gln Uncertain significance Single submitter
- DPP3 p.Arg548Gln Uncertain significance Single submitter
- DPP3 p.Arg602Gln Uncertain significance Single submitter
- DPP3 p.Arg611Gln Uncertain significance Single submitter
- DPP3 p.Arg665Cys Uncertain significance Single submitter
- DPP3 p.Arg665Pro Uncertain significance Single submitter
- DPP3 p.Arg68His Uncertain significance Single submitter
- DPP3 p.Asn10Ser Uncertain significance Single submitter
- DPP3 p.Asp11Gly Uncertain significance Single submitter
- DPP3 p.Asp303Glu Uncertain significance Single submitter
- DPP3 p.Asp396Asn Uncertain significance Single submitter
- DPP3 p.Asp73Glu Uncertain significance Single submitter
- DPP3 p.Cys509Arg Uncertain significance Single submitter
- DPP3 p.Glu213Val Uncertain significance Single submitter
- DPP3 p.Glu316Lys Uncertain significance Single submitter
- DPP3 p.Glu329Gly Uncertain significance Single submitter
- DPP3 p.Glu710Lys Uncertain significance Single submitter
- DPP3 p.Gly148Arg Uncertain significance Single submitter
- DPP3 p.Gly385Cys Uncertain significance Single submitter
- DPP3 p.Gly389Ser Uncertain significance Single submitter
- DPP3 p.Gly410Arg Uncertain significance Single submitter
- DPP3 p.Gly594Ala Uncertain significance Single submitter
- DPP3 p.His273Asn Uncertain significance Single submitter
- DPP3 p.Ile12Val Uncertain significance Single submitter
- DPP3 p.Ile436Val Uncertain significance Single submitter
- DPP3 p.Ile59Leu Uncertain significance Single submitter
- DPP3 p.Ile7Leu Uncertain significance Single submitter
- DPP3 p.Leu143Pro Uncertain significance Single submitter
- DPP3 p.Leu150Phe Uncertain significance Single submitter
- DPP3 p.Leu226Val Uncertain significance Single submitter
- DPP3 p.Leu618Val Uncertain significance Single submitter
- DPP3 p.Lys113Asn Uncertain significance Single submitter
- DPP3 p.Met178Thr Uncertain significance Single submitter
- DPP3 p.Met178Val Uncertain significance Single submitter
- DPP3 p.Met339Thr Uncertain significance Single submitter
- DPP3 p.Phe404Ile Uncertain significance Single submitter
- DPP3 p.Phe562Leu Uncertain significance Single submitter
- DPP3 p.Pro210Ser Uncertain significance Single submitter
- DPP3 p.Pro358Ser Uncertain significance Single submitter
- DPP3 p.Pro9Thr Uncertain significance Single submitter
- DPP3 p.Ser108Tyr Uncertain significance Single submitter
- DPP3 p.Ser15Cys Uncertain significance Single submitter
- DPP3 p.Ser16Asn Uncertain significance Single submitter
- DPP3 p.Ser225Pro Uncertain significance Single submitter
- DPP3 p.Ser500Cys Uncertain significance Single submitter
- DPP3 p.Ser668Thr Uncertain significance Single submitter
- DPP3 p.Thr247Ile Uncertain significance Single submitter
- DPP3 p.Tyr171Cys Uncertain significance Single submitter
- DPP3 p.Tyr33Cys Uncertain significance Single submitter
- DPP3 p.Tyr489Cys Uncertain significance Single submitter
- DPP3 p.Val308Met Uncertain significance Single submitter
- DPP3 p.Val447Met Uncertain significance Single submitter
- DPP3 p.Val462Ile Uncertain significance Single submitter
Predictors split 80
The independent predictors disagree with each other — read with care.
- DPP3 p.Arg76His Benign Multiple submitters
- DPP3 p.Leu163Met Benign Multiple submitters
- DPP3 p.Ala22Gly Uncertain significance Single submitter
- DPP3 p.Ala22Thr Uncertain significance Single submitter
- DPP3 p.Ala535Val Uncertain significance Single submitter
- DPP3 p.Ala56Val Uncertain significance Single submitter
- DPP3 p.Ala571Ser Uncertain significance Single submitter
- DPP3 p.Ala582Ser Uncertain significance Single submitter
- DPP3 p.Ala650Val Uncertain significance Single submitter
- DPP3 p.Ala69Thr Uncertain significance Single submitter
- DPP3 p.Arg20Cys Uncertain significance Single submitter
- DPP3 p.Arg240Trp Uncertain significance Single submitter
- DPP3 p.Arg248Trp Uncertain significance Single submitter
- DPP3 p.Arg24Cys Uncertain significance Single submitter
- DPP3 p.Arg298His Uncertain significance Single submitter
- DPP3 p.Arg345Gln Uncertain significance Single submitter
- DPP3 p.Arg39His Uncertain significance Single submitter
- DPP3 p.Arg421Trp Uncertain significance Single submitter
- DPP3 p.Arg490Gln Uncertain significance Single submitter
- DPP3 p.Arg565Leu Uncertain significance Single submitter
- DPP3 p.Arg602Trp Uncertain significance Single submitter
- DPP3 p.Arg76Cys Uncertain significance Single submitter
- DPP3 p.Asp186His Uncertain significance Single submitter
- DPP3 p.Asp205Asn Uncertain significance Single submitter
- DPP3 p.Asp366Asn Uncertain significance Single submitter
- DPP3 p.Asp596Asn Uncertain significance Single submitter
- DPP3 p.Asp73Asn Uncertain significance Single submitter
- DPP3 p.Asp73His Uncertain significance Single submitter
- DPP3 p.Cys519Ser Uncertain significance Single submitter
- DPP3 p.Gln276Arg Uncertain significance Single submitter
- DPP3 p.Gln276Lys Uncertain significance Single submitter
- DPP3 p.Gln280Arg Uncertain significance Single submitter
- DPP3 p.Glu213Gly Uncertain significance Single submitter
- DPP3 p.Glu291Lys Uncertain significance Single submitter
- DPP3 p.Glu465Lys Uncertain significance Single submitter
- DPP3 p.Glu483Asp Uncertain significance Single submitter
- DPP3 p.Glu581Ala Uncertain significance Single submitter
- DPP3 p.Glu642Lys Benign Single submitter
- DPP3 p.Glu653Lys Uncertain significance Single submitter
- DPP3 p.Glu86Lys Uncertain significance Single submitter
- DPP3 p.Gly174Arg Uncertain significance Single submitter
- DPP3 p.Gly305Val Uncertain significance Single submitter
- DPP3 p.Gly385Ser Uncertain significance Single submitter
- DPP3 p.Gly492Arg Uncertain significance Single submitter
- DPP3 p.Gly597Arg Uncertain significance Single submitter
- DPP3 p.Gly636Arg Uncertain significance Single submitter
- DPP3 p.His160Tyr Uncertain significance Single submitter
- DPP3 p.His521Tyr Conflicting Single submitter
- DPP3 p.Ile282Met Uncertain significance Single submitter
- DPP3 p.Ile312Val Uncertain significance Single submitter
- DPP3 p.Ile672Thr Uncertain significance Single submitter
- DPP3 p.Leu183Ser Uncertain significance Single submitter
- DPP3 p.Leu715Phe Uncertain significance Single submitter
- DPP3 p.Lys367Asn Uncertain significance Single submitter
- DPP3 p.Phe530Ser Uncertain significance Single submitter
- DPP3 p.Pro253Leu Uncertain significance Single submitter
- DPP3 p.Pro253Ser Uncertain significance Single submitter
- DPP3 p.Pro28Ser Uncertain significance Single submitter
- DPP3 p.Pro54Leu Uncertain significance Single submitter
- DPP3 p.Pro57Ser Uncertain significance Single submitter
- DPP3 p.Pro599Ser Uncertain significance Single submitter
- DPP3 p.Pro651Thr Uncertain significance Single submitter
- DPP3 p.Pro652Leu Uncertain significance Single submitter
- DPP3 p.Pro652Ser Uncertain significance Single submitter
- DPP3 p.Ser101Tyr Uncertain significance Single submitter
- DPP3 p.Ser236Gly Uncertain significance Single submitter
- DPP3 p.Ser317Gly Uncertain significance Single submitter
- DPP3 p.Ser408Leu Uncertain significance Single submitter
- DPP3 p.Ser730Ile Uncertain significance Single submitter
- DPP3 p.Ser734Cys Uncertain significance Single submitter
- DPP3 p.Thr401Met Uncertain significance Single submitter
- DPP3 p.Thr475Ile Uncertain significance Single submitter
- DPP3 p.Val126Met Uncertain significance Single submitter
- DPP3 p.Val258Ala Uncertain significance Single submitter
- DPP3 p.Val258Leu Uncertain significance Single submitter
- DPP3 p.Val332Ile Uncertain significance Single submitter
- DPP3 p.Val335Met Uncertain significance Single submitter
- DPP3 p.Val378Ile Uncertain significance Single submitter
- DPP3 p.Val538Met Uncertain significance Single submitter
- DPP3 p.Val684Met Uncertain significance Single submitter
All DPP3 variants
Conflicting classifications of pathogenicity 1
- p.His521Tyr Single submitter ⚠
Benign 10
- p.Arg76His Multiple submitters ⚠
- p.Leu163Met Multiple submitters ⚠
- p.Lys423= Multiple submitters
- p.Phe331= Multiple submitters
- p.Phe443= Multiple submitters
- p.Thr401= Multiple submitters
- c.271-5C>A Single submitter
- c.271-5C>G Single submitter
- c.498+9C>G Single submitter
- p.Glu642Lys Single submitter ⚠
Likely benign 1
- p.Ala348= Single submitter
Uncertain significance 134
- c.573+1G>A Single submitter
- p.Ala22Gly Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala252Thr Single submitter ⚠
- p.Ala382Pro Single submitter ⚠
- p.Ala535Val Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Ala571Ser Single submitter ⚠
- p.Ala582Ser Single submitter ⚠
- p.Ala650Val Single submitter ⚠
- p.Ala69Thr Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg20His Single submitter ⚠
- p.Arg240Trp Single submitter ⚠
- p.Arg248Trp Single submitter ⚠
- p.Arg24Cys Single submitter ⚠
- p.Arg298His Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg421Trp Single submitter ⚠
- p.Arg490Gln Single submitter ⚠
- p.Arg510Gln Single submitter ⚠
- p.Arg548Gln Single submitter ⚠
- p.Arg565Leu Single submitter ⚠
- p.Arg602Gln Single submitter ⚠
- p.Arg602Trp Single submitter ⚠
- p.Arg611Gln Single submitter ⚠
- p.Arg665Cys Single submitter ⚠
- p.Arg665Pro Single submitter ⚠
- p.Arg68His Single submitter ⚠
- p.Arg76Cys Single submitter ⚠
- p.Asn10Ser Single submitter ⚠
- p.Asp11Gly Single submitter ⚠
- p.Asp186His Single submitter ⚠
- p.Asp205Asn Single submitter ⚠
- p.Asp303Glu Single submitter ⚠
- p.Asp366Asn Single submitter ⚠
- p.Asp396Asn Single submitter ⚠
- p.Asp596Asn Single submitter ⚠
- p.Asp73Asn Single submitter ⚠
- p.Asp73Glu Single submitter ⚠
- p.Asp73His Single submitter ⚠
- p.Cys509Arg Single submitter ⚠
- p.Cys519Ser Single submitter ⚠
- p.Gln276Arg Single submitter ⚠
- p.Gln276Lys Single submitter ⚠
- p.Gln280Arg Single submitter ⚠
- p.Glu213Gly Single submitter ⚠
- p.Glu213Val Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu316Lys Single submitter ⚠
- p.Glu329Gly Single submitter ⚠
- p.Glu465Lys Single submitter ⚠
- p.Glu483Asp Single submitter ⚠
- p.Glu581Ala Single submitter ⚠
- p.Glu653Lys Single submitter ⚠
- p.Glu710Lys Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly174Arg Single submitter ⚠
- p.Gly305Val Single submitter ⚠
- p.Gly385Cys Single submitter ⚠
- p.Gly385Ser Single submitter ⚠
- p.Gly389Ser Single submitter ⚠
- p.Gly410Arg Single submitter ⚠
- p.Gly492Arg Single submitter ⚠
- p.Gly594Ala Single submitter ⚠
- p.Gly597Arg Single submitter ⚠
- p.Gly636Arg Single submitter ⚠
- p.His160Tyr Single submitter ⚠
- p.His273Asn Single submitter ⚠
- p.Ile12Val Single submitter ⚠
- p.Ile282Met Single submitter ⚠
- p.Ile312Val Single submitter ⚠
- p.Ile436Val Single submitter ⚠
- p.Ile59Leu Single submitter ⚠
- p.Ile672Thr Single submitter ⚠
- p.Ile7Leu Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Leu150Phe Single submitter ⚠
- p.Leu183Ser Single submitter ⚠
- p.Leu226Val Single submitter ⚠
- p.Leu618Val Single submitter ⚠
- p.Leu715Phe Single submitter ⚠
- p.Lys113Asn Single submitter ⚠
- p.Lys367Asn Single submitter ⚠
- p.Met178Thr Single submitter ⚠
- p.Met178Val Single submitter ⚠
- p.Met339Thr Single submitter ⚠
- p.Phe404Ile Single submitter ⚠
- p.Phe530Ser Single submitter ⚠
- p.Phe562Leu Single submitter ⚠
- p.Pro210Ser Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Pro253Ser Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Pro358Ser Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Pro599Ser Single submitter ⚠
- p.Pro651Thr Single submitter ⚠
- p.Pro652Leu Single submitter ⚠
- p.Pro652Ser Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser101Tyr Single submitter ⚠
- p.Ser108Tyr Single submitter ⚠
- p.Ser15Cys Single submitter ⚠
- p.Ser16Asn Single submitter ⚠
- p.Ser225Pro Single submitter ⚠
- p.Ser236Gly Single submitter ⚠
- p.Ser317Gly Single submitter ⚠
- p.Ser408Leu Single submitter ⚠
- p.Ser500Cys Single submitter ⚠
- p.Ser668Thr Single submitter ⚠
- p.Ser730Ile Single submitter ⚠
- p.Ser734Cys Single submitter ⚠
- p.Thr247Ile Single submitter ⚠
- p.Thr401Met Single submitter ⚠
- p.Thr475Ile Single submitter ⚠
- p.Tyr171Cys Single submitter ⚠
- p.Tyr33Cys Single submitter ⚠
- p.Tyr489Cys Single submitter ⚠
- p.Val126Met Single submitter ⚠
- p.Val258Ala Single submitter ⚠
- p.Val258Leu Single submitter ⚠
- p.Val308Met Single submitter ⚠
- p.Val332Ile Single submitter ⚠
- p.Val335Met Single submitter ⚠
- p.Val378Ile Single submitter ⚠
- p.Val447Met Single submitter ⚠
- p.Val462Ile Single submitter ⚠
- p.Val538Met Single submitter ⚠
- p.Val684Met Single submitter ⚠