DPP4 — 111 ClinVar variants
All ClinVar germline DPP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
6 Benign · 10 Likely benign · 95 Uncertain significance
Full DPP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPP4 p.Ala654Thr Uncertain significance Single submitter
- DPP4 p.Arg40Ser Uncertain significance Single submitter
- DPP4 p.Asn103Tyr Uncertain significance Single submitter
- DPP4 p.Asn169Ser Uncertain significance Single submitter
- DPP4 p.Asn450Tyr Uncertain significance Single submitter
- DPP4 p.Asp33Gly Uncertain significance Single submitter
- DPP4 p.Asp34Gly Uncertain significance Single submitter
- DPP4 p.Gln469Leu Uncertain significance Single submitter
- DPP4 p.Glu448Gln Uncertain significance Single submitter
- DPP4 p.Glu464Gly Uncertain significance Single submitter
- DPP4 p.Glu571Lys Uncertain significance Single submitter
- DPP4 p.Gly161Val Uncertain significance Single submitter
- DPP4 p.Gly220Asp Uncertain significance Single submitter
- DPP4 p.Gly406Val Uncertain significance Single submitter
- DPP4 p.Gly424Glu Uncertain significance Single submitter
- DPP4 p.Gly584Val Uncertain significance Single submitter
- DPP4 p.Gly599Glu Uncertain significance Single submitter
- DPP4 p.Gly628Val Uncertain significance Single submitter
- DPP4 p.His100Gln Uncertain significance Single submitter
- DPP4 p.His345Arg Uncertain significance Single submitter
- DPP4 p.His592Arg Uncertain significance Single submitter
- DPP4 p.His704Tyr Uncertain significance Single submitter
- DPP4 p.Ile285Thr Uncertain significance Single submitter
- DPP4 p.Ile626Val Uncertain significance Single submitter
- DPP4 p.Ile742Leu Uncertain significance Single submitter
- DPP4 p.Leu410Val Uncertain significance Single submitter
- DPP4 p.Leu680Phe Uncertain significance Single submitter
- DPP4 p.Met348Ile Uncertain significance Single submitter
- DPP4 p.Phe713Leu Uncertain significance Single submitter
- DPP4 p.Pro234Ala Uncertain significance Single submitter
- DPP4 p.Pro257Leu Uncertain significance Single submitter
- DPP4 p.Ser644Arg Uncertain significance Single submitter
- DPP4 p.Ser657Phe Uncertain significance Single submitter
- DPP4 p.Thr251Ala Uncertain significance Single submitter
- DPP4 p.Trp734Cys Uncertain significance Single submitter
- DPP4 p.Tyr256His Uncertain significance Single submitter
- DPP4 p.Tyr417His Uncertain significance Single submitter
- DPP4 p.Tyr467Cys Uncertain significance Single submitter
- DPP4 p.Tyr68Cys Uncertain significance Single submitter
- DPP4 p.Val155Ala Uncertain significance Single submitter
Predictors split 57
The independent predictors disagree with each other — read with care.
- DPP4 p.Ser437Thr Benign Multiple submitters
- DPP4 p.Val266Ile Likely benign Multiple submitters
- DPP4 p.Ala81Thr Uncertain significance Single submitter
- DPP4 p.Arg253Trp Uncertain significance Single submitter
- DPP4 p.Arg40Cys Uncertain significance Single submitter
- DPP4 p.Arg40His Uncertain significance Single submitter
- DPP4 p.Asn281His Uncertain significance Single submitter
- DPP4 p.Asn338Lys Uncertain significance Single submitter
- DPP4 p.Asn487Lys Uncertain significance Single submitter
- DPP4 p.Asn80Ser Uncertain significance Single submitter
- DPP4 p.Asp136His Uncertain significance Single submitter
- DPP4 p.Asp331His Uncertain significance Single submitter
- DPP4 p.Asp65Gly Uncertain significance Single submitter
- DPP4 p.Gln153Glu Uncertain significance Single submitter
- DPP4 p.Gln247Pro Uncertain significance Single submitter
- DPP4 p.Gln612Lys Uncertain significance Single submitter
- DPP4 p.Glu67Val Uncertain significance Single submitter
- DPP4 p.Gly380Ala Uncertain significance Single submitter
- DPP4 p.Gly643Ala Uncertain significance Single submitter
- DPP4 p.Gly84Arg Uncertain significance Single submitter
- DPP4 p.Ile107Thr Uncertain significance Single submitter
- DPP4 p.Ile148Met Uncertain significance Single submitter
- DPP4 p.Ile194Met Uncertain significance Single submitter
- DPP4 p.Ile311Val Uncertain significance Single submitter
- DPP4 p.Ile573Thr Uncertain significance Single submitter
- DPP4 p.Ile574Met Uncertain significance Single submitter
- DPP4 p.Ile626Met Uncertain significance Single submitter
- DPP4 p.Leu276His Uncertain significance Single submitter
- DPP4 p.Lys392Ile Uncertain significance Single submitter
- DPP4 p.Lys441Thr Uncertain significance Single submitter
- DPP4 p.Lys512Glu Uncertain significance Single submitter
- DPP4 p.Lys513Asn Uncertain significance Single submitter
- DPP4 p.Met509Ile Uncertain significance Single submitter
- DPP4 p.Met528Val Uncertain significance Single submitter
- DPP4 p.Phe95Ser Uncertain significance Single submitter
- DPP4 p.Pro181Ser Uncertain significance Single submitter
- DPP4 p.Ser108Ala Uncertain significance Single submitter
- DPP4 p.Ser277Ile Uncertain significance Single submitter
- DPP4 p.Ser334Gly Uncertain significance Single submitter
- DPP4 p.Ser419Gly Uncertain significance Single submitter
- DPP4 p.Ser485Asn Uncertain significance Single submitter
- DPP4 p.Ser642Leu Uncertain significance Single submitter
- DPP4 p.Ser690Ile Uncertain significance Single submitter
- DPP4 p.Ser86Ile Uncertain significance Single submitter
- DPP4 p.Thr188Met Uncertain significance Single submitter
- DPP4 p.Thr265Ala Uncertain significance Single submitter
- DPP4 p.Thr443Ile Uncertain significance Single submitter
- DPP4 p.Thr481Ile Uncertain significance Single submitter
- DPP4 p.Thr600Ala Uncertain significance Single submitter
- DPP4 p.Thr675Ala Uncertain significance Single submitter
- DPP4 p.Thr94Ile Uncertain significance Single submitter
- DPP4 p.Tyr299Cys Uncertain significance Single submitter
- DPP4 p.Tyr372Cys Uncertain significance Single submitter
- DPP4 p.Tyr439Cys Uncertain significance Single submitter
- DPP4 p.Tyr752His Uncertain significance Single submitter
- DPP4 p.Val270Leu Uncertain significance Single submitter
- DPP4 p.Val7Leu Uncertain significance Single submitter
All DPP4 variants
Benign 6
- c.1987+4T>C Multiple submitters
- p.Ala16= Multiple submitters
- p.Gly645= Multiple submitters
- p.Leu27= Multiple submitters
- p.Ser437Thr Multiple submitters ⚠
- c.1887+3G>A Single submitter
Likely benign 10
- p.Lys539= Multiple submitters
- p.Val266Ile Multiple submitters ⚠
- c.1298+7G>A Single submitter
- c.1637+10C>T Single submitter
- p.Gly296= Single submitter
- p.Ile63Val Single submitter
- p.Leu415= Single submitter
- p.Met293Val Single submitter
- p.Ser376= Single submitter
- p.Ser716= Single submitter
Uncertain significance 95
- p.Ala654Thr Single submitter ⚠
- p.Ala81Thr Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Arg40Cys Single submitter ⚠
- p.Arg40His Single submitter ⚠
- p.Arg40Ser Single submitter ⚠
- p.Asn103Tyr Single submitter ⚠
- p.Asn169Ser Single submitter ⚠
- p.Asn281His Single submitter ⚠
- p.Asn338Lys Single submitter ⚠
- p.Asn450Tyr Single submitter ⚠
- p.Asn487Lys Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Asp136His Single submitter ⚠
- p.Asp331His Single submitter ⚠
- p.Asp33Gly Single submitter ⚠
- p.Asp34Gly Single submitter ⚠
- p.Asp65Gly Single submitter ⚠
- p.Gln153Glu Single submitter ⚠
- p.Gln247Pro Single submitter ⚠
- p.Gln469Leu Single submitter ⚠
- p.Gln612Lys Single submitter ⚠
- p.Glu448Gln Single submitter ⚠
- p.Glu464Gly Single submitter ⚠
- p.Glu571Lys Single submitter ⚠
- p.Glu67Val Single submitter ⚠
- p.Gly161Val Single submitter ⚠
- p.Gly220Asp Single submitter ⚠
- p.Gly380Ala Single submitter ⚠
- p.Gly406Val Single submitter ⚠
- p.Gly424Glu Single submitter ⚠
- p.Gly584Val Single submitter ⚠
- p.Gly599Glu Single submitter ⚠
- p.Gly628Val Single submitter ⚠
- p.Gly643Ala Single submitter ⚠
- p.Gly84Arg Single submitter ⚠
- p.His100Gln Single submitter ⚠
- p.His345Arg Single submitter ⚠
- p.His592Arg Single submitter ⚠
- p.His704Tyr Single submitter ⚠
- p.Ile107Thr Single submitter ⚠
- p.Ile148Met Single submitter ⚠
- p.Ile194Met Single submitter ⚠
- p.Ile285Thr Single submitter ⚠
- p.Ile311Val Single submitter ⚠
- p.Ile573Thr Single submitter ⚠
- p.Ile574Met Single submitter ⚠
- p.Ile626Met Single submitter ⚠
- p.Ile626Val Single submitter ⚠
- p.Ile742Leu Single submitter ⚠
- p.Leu276His Single submitter ⚠
- p.Leu410Val Single submitter ⚠
- p.Leu680Phe Single submitter ⚠
- p.Lys392Ile Single submitter ⚠
- p.Lys441Thr Single submitter ⚠
- p.Lys512Glu Single submitter ⚠
- p.Lys513Asn Single submitter ⚠
- p.Met348Ile Single submitter ⚠
- p.Met509Ile Single submitter ⚠
- p.Met528Val Single submitter ⚠
- p.Phe713Leu Single submitter ⚠
- p.Phe95Ser Single submitter ⚠
- p.Pro181Ser Single submitter ⚠
- p.Pro234Ala Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Ser108Ala Single submitter ⚠
- p.Ser277Ile Single submitter ⚠
- p.Ser334Gly Single submitter ⚠
- p.Ser419Gly Single submitter ⚠
- p.Ser485Asn Single submitter ⚠
- p.Ser642Leu Single submitter ⚠
- p.Ser644Arg Single submitter ⚠
- p.Ser657Phe Single submitter ⚠
- p.Ser690Ile Single submitter ⚠
- p.Ser86Ile Single submitter ⚠
- p.Thr188Met Single submitter ⚠
- p.Thr251Ala Single submitter ⚠
- p.Thr265Ala Single submitter ⚠
- p.Thr443Ile Single submitter ⚠
- p.Thr481Ile Single submitter ⚠
- p.Thr600Ala Single submitter ⚠
- p.Thr675Ala Single submitter ⚠
- p.Thr94Ile Single submitter ⚠
- p.Trp734Cys Single submitter ⚠
- p.Tyr256His Single submitter ⚠
- p.Tyr299Cys Single submitter ⚠
- p.Tyr372Cys Single submitter ⚠
- p.Tyr417His Single submitter ⚠
- p.Tyr439Cys Single submitter ⚠
- p.Tyr467Cys Single submitter ⚠
- p.Tyr68Cys Single submitter ⚠
- p.Tyr752His Single submitter ⚠
- p.Val155Ala Single submitter ⚠
- p.Val270Leu Single submitter ⚠
- p.Val7Leu Single submitter ⚠