DPP7 — 139 ClinVar variants

All ClinVar germline DPP7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 132 flagged for review →

8 Likely benign · 131 Uncertain significance

Full DPP7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 132

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 60

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 72

The independent predictors disagree with each other — read with care.

All DPP7 variants

Likely benign 8

p.Arg17= Multiple submitters
p.Ala21Thr Single submitter ⚠
p.Ala92Val Single submitter
p.Arg327Gln Single submitter
p.Arg426Gln Single submitter
p.Gly99= Single submitter
p.Ser3= Single submitter
p.Val436Ile Single submitter

Uncertain significance 131

p.Ala118Gly Single submitter ⚠
p.Ala118Val Single submitter ⚠
p.Ala136Val Single submitter ⚠
p.Ala139Gly Single submitter ⚠
p.Ala13Val Single submitter ⚠
p.Ala158Asp Single submitter ⚠
p.Ala182Thr Single submitter ⚠
p.Ala184Thr Single submitter ⚠
p.Ala185Val Single submitter ⚠
p.Ala207Val Single submitter ⚠
p.Ala21Glu Single submitter ⚠
p.Ala262Thr Single submitter ⚠
p.Ala316Val Single submitter ⚠
p.Ala344Thr Single submitter ⚠
p.Ala360Thr Single submitter ⚠
p.Ala407Thr Single submitter ⚠
p.Ala461Val Single submitter ⚠
p.Ala466Asp Single submitter ⚠
p.Ala83Val Single submitter ⚠
p.Ala89Thr Single submitter ⚠
p.Ala95Pro Single submitter ⚠
p.Arg108Leu Single submitter ⚠
p.Arg123Cys Single submitter ⚠
p.Arg123His Single submitter ⚠
p.Arg143Cys Single submitter ⚠
p.Arg143Leu Single submitter ⚠
p.Arg17Cys Single submitter ⚠
p.Arg203Trp Single submitter ⚠
p.Arg240Gly Single submitter ⚠
p.Arg240Leu Single submitter ⚠
p.Arg24His Single submitter ⚠
p.Arg302Gly Single submitter ⚠
p.Arg378His Single submitter ⚠
p.Arg380Leu Single submitter ⚠
p.Arg39Cys Single submitter ⚠
p.Arg39Pro Single submitter ⚠
p.Arg426Trp Single submitter ⚠
p.Arg462Gln Single submitter ⚠
p.Arg478Cys Single submitter ⚠
p.Arg478His Single submitter ⚠
p.Arg47Pro Single submitter ⚠
p.Arg62Thr Single submitter ⚠
p.Arg66Trp Single submitter ⚠
p.Arg98Pro Single submitter ⚠
p.Arg98Trp Single submitter ⚠
p.Asn50His Single submitter ⚠
p.Asp137Asn Single submitter ⚠
p.Asp153Asn Single submitter ⚠
p.Asp28Asn Single submitter ⚠
p.Asp324Asn Single submitter ⚠
p.Asp343Asn Single submitter ⚠
p.Asp366His Single submitter ⚠
p.Asp446Asn Single submitter ⚠
p.Gln218His Single submitter ⚠
p.Glu132Asp Single submitter ⚠
p.Glu252Lys Single submitter ⚠
p.Glu320Lys Single submitter ⚠
p.Glu354Asp Single submitter ⚠
p.Glu376Asp Single submitter ⚠
p.Glu376Lys Single submitter ⚠
p.Glu46Lys Single submitter ⚠
p.Glu471Lys Single submitter ⚠
p.Glu479Gln Single submitter ⚠
p.Gly150Arg Single submitter ⚠
p.Gly18Cys Single submitter ⚠
p.Gly194Ala Single submitter ⚠
p.Gly194Asp Single submitter ⚠
p.Gly22Ala Single submitter ⚠
p.Gly22Arg Single submitter ⚠
p.Gly22Trp Single submitter ⚠
p.Gly234Glu Single submitter ⚠
p.Gly305Glu Single submitter ⚠
p.Gly339Ser Single submitter ⚠
p.Gly341Ser Single submitter ⚠
p.Gly341Val Single submitter ⚠
p.Gly423Ser Single submitter ⚠
p.Gly440Arg Single submitter ⚠
p.Gly441Ala Single submitter ⚠
p.Gly470Ser Single submitter ⚠
p.Gly486Arg Single submitter ⚠
p.Gly49Asp Single submitter ⚠
p.Gly49Ser Single submitter ⚠
p.Gly69Glu Single submitter ⚠
p.Gly79Asp Single submitter ⚠
p.His125Arg Single submitter ⚠
p.His443Arg Single submitter ⚠
p.His443Gln Single submitter ⚠
p.Ile157Met Single submitter ⚠
p.Ile411Phe Single submitter ⚠
p.Leu101Val Single submitter ⚠
p.Leu142Val Single submitter ⚠
p.Leu149Arg Single submitter ⚠
p.Leu195Pro Single submitter ⚠
p.Leu230Phe Single submitter ⚠
p.Leu429Pro Single submitter ⚠
p.Lys215Arg Single submitter ⚠
p.Phe209Cys Single submitter ⚠
p.Phe261Leu Single submitter ⚠
p.Phe36Leu Single submitter ⚠
p.Phe412Ile Single submitter ⚠
p.Phe412Leu Single submitter ⚠
p.Phe48Ser Single submitter ⚠
p.Phe72Ile Single submitter ⚠
p.Phe72Leu Single submitter ⚠
p.Pro277Leu Single submitter ⚠
p.Pro283Ser Single submitter ⚠
p.Pro452Ala Single submitter ⚠
p.Pro5Leu Single submitter ⚠
p.Ser186Arg Single submitter ⚠
p.Ser186Thr Single submitter ⚠
p.Ser317Leu Single submitter ⚠
p.Ser331Gly Single submitter ⚠
p.Ser432Pro Single submitter ⚠
p.Ser450Cys Single submitter ⚠
p.Thr121Pro Single submitter ⚠
p.Thr206Lys Single submitter ⚠
p.Thr238Met Single submitter ⚠
p.Thr304Met Single submitter ⚠
p.Thr374Ala Single submitter ⚠
p.Thr397Asn Single submitter ⚠
p.Thr75Ala Single submitter ⚠
p.Trp347Ser Single submitter ⚠
p.Trp400Cys Single submitter ⚠
p.Trp400Ser Single submitter ⚠
p.Trp6Ser Single submitter ⚠
p.Tyr314His Single submitter ⚠
p.Val189Ile Single submitter ⚠
p.Val268Met Single submitter ⚠
p.Val364Met Single submitter ⚠
p.Val436Phe Single submitter ⚠
p.Val458Met Single submitter ⚠