DPP8 — 87 ClinVar variants
All ClinVar germline DPP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
1 Likely benign · 86 Uncertain significance
Full DPP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPP8 c.-12+1811G>T Uncertain significance Single submitter
- DPP8 c.-12+1828C>T Uncertain significance Single submitter
- DPP8 p.Ala110Thr Uncertain significance Single submitter
- DPP8 p.Ala18Val Uncertain significance Single submitter
- DPP8 p.Ala602Ser Uncertain significance Single submitter
- DPP8 p.Ala602Val Uncertain significance Single submitter
- DPP8 p.Ala759Thr Uncertain significance Single submitter
- DPP8 p.Arg231Lys Uncertain significance Single submitter
- DPP8 p.Arg284Lys Uncertain significance Single submitter
- DPP8 p.Arg29Gly Uncertain significance Single submitter
- DPP8 p.Arg385His Uncertain significance Single submitter
- DPP8 p.Arg39Gln Uncertain significance Single submitter
- DPP8 p.Arg477Leu Uncertain significance Single submitter
- DPP8 p.Arg553Cys Uncertain significance Single submitter
- DPP8 p.Arg553Gly Uncertain significance Single submitter
- DPP8 p.Arg664Gln Uncertain significance Single submitter
- DPP8 p.Asn238Asp Uncertain significance Single submitter
- DPP8 p.Asn23Asp Uncertain significance Single submitter
- DPP8 p.Asn543Ser Uncertain significance Single submitter
- DPP8 p.Asn662Thr Uncertain significance Single submitter
- DPP8 p.Asp128Asn Uncertain significance Single submitter
- DPP8 p.Asp246Asn Uncertain significance Single submitter
- DPP8 p.Asp401Tyr Uncertain significance Single submitter
- DPP8 p.Cys580Ser Uncertain significance Single submitter
- DPP8 p.Cys595Tyr Uncertain significance Single submitter
- DPP8 p.Gln514Arg Uncertain significance Single submitter
- DPP8 p.Gly554Ser Uncertain significance Single submitter
- DPP8 p.Gly737Ser Uncertain significance Single submitter
- DPP8 p.Ile225Val Uncertain significance Single submitter
- DPP8 p.Ile377Met Uncertain significance Single submitter
- DPP8 p.Leu532Ser Uncertain significance Single submitter
- DPP8 p.Met200Val Uncertain significance Single submitter
- DPP8 p.Met243Ile Uncertain significance Single submitter
- DPP8 p.Met243Thr Uncertain significance Single submitter
- DPP8 p.Met304Val Uncertain significance Single submitter
- DPP8 p.Met404Leu Uncertain significance Single submitter
- DPP8 p.Met5Val Uncertain significance Single submitter
- DPP8 p.Met88Val Uncertain significance Single submitter
- DPP8 p.Pro178Leu Uncertain significance Single submitter
- DPP8 p.Pro64Leu Uncertain significance Single submitter
- DPP8 p.Pro764Ala Uncertain significance Single submitter
- DPP8 p.Ser115Pro Uncertain significance Single submitter
- DPP8 p.Ser26Leu Uncertain significance Single submitter
- DPP8 p.Ser443Asn Uncertain significance Single submitter
- DPP8 p.Thr147Ile Uncertain significance Single submitter
- DPP8 p.Thr326Ala Uncertain significance Single submitter
- DPP8 p.Thr52Asn Uncertain significance Single submitter
- DPP8 p.Trp221Cys Uncertain significance Single submitter
- DPP8 p.Tyr84Cys Uncertain significance Single submitter
- DPP8 p.Val542Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- DPP8 p.Thr182Met Uncertain significance Multiple submitters
- DPP8 p.Thr227Ser Uncertain significance Multiple submitters
- DPP8 p.Ala374Gly Uncertain significance Single submitter
- DPP8 p.Ala497Thr Uncertain significance Single submitter
- DPP8 p.Ala701Thr Uncertain significance Single submitter
- DPP8 p.Ala701Val Uncertain significance Single submitter
- DPP8 p.Arg385Cys Uncertain significance Single submitter
- DPP8 p.Arg519Lys Uncertain significance Single submitter
- DPP8 p.Asn107Ser Uncertain significance Single submitter
- DPP8 p.Asn92Lys Uncertain significance Single submitter
- DPP8 p.Glu192Asp Uncertain significance Single submitter
- DPP8 p.Glu353Gly Uncertain significance Single submitter
- DPP8 p.Glu400Asp Uncertain significance Single submitter
- DPP8 p.Gly280Arg Uncertain significance Single submitter
- DPP8 p.Ile225Thr Uncertain significance Single submitter
- DPP8 p.Ile332Leu Uncertain significance Single submitter
- DPP8 p.Ile340Phe Uncertain significance Single submitter
- DPP8 p.Ile349Met Uncertain significance Single submitter
- DPP8 p.Ile421Thr Uncertain significance Single submitter
- DPP8 p.Ile496Lys Uncertain significance Single submitter
- DPP8 p.Ile728Leu Uncertain significance Single submitter
- DPP8 p.Ile851Met Uncertain significance Single submitter
- DPP8 p.Leu634Phe Uncertain significance Single submitter
- DPP8 p.Lys117Met Uncertain significance Single submitter
- DPP8 p.Lys203Glu Uncertain significance Single submitter
- DPP8 p.Met88Ile Uncertain significance Single submitter
- DPP8 p.Phe162Leu Uncertain significance Single submitter
- DPP8 p.Phe815Leu Uncertain significance Single submitter
- DPP8 p.Pro398Leu Uncertain significance Single submitter
- DPP8 p.Pro441Ser Uncertain significance Single submitter
- DPP8 p.Pro491Arg Uncertain significance Single submitter
- DPP8 p.Ser412Pro Uncertain significance Single submitter
- DPP8 p.Ser478Phe Uncertain significance Single submitter
- DPP8 p.Ser558Cys Uncertain significance Single submitter
- DPP8 p.Val343Ile Uncertain significance Single submitter
- DPP8 p.Val515Ile Uncertain significance Single submitter
All DPP8 variants
Likely benign 1
- p.Arg29Gln Single submitter
Uncertain significance 86
- p.Thr182Met Multiple submitters ⚠
- p.Thr227Ser Multiple submitters ⚠
- c.-12+1811G>T Single submitter ⚠
- c.-12+1828C>T Single submitter ⚠
- p.Ala110Thr Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala374Gly Single submitter ⚠
- p.Ala497Thr Single submitter ⚠
- p.Ala602Ser Single submitter ⚠
- p.Ala602Val Single submitter ⚠
- p.Ala701Thr Single submitter ⚠
- p.Ala701Val Single submitter ⚠
- p.Ala759Thr Single submitter ⚠
- p.Arg231Lys Single submitter ⚠
- p.Arg284Lys Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg385Cys Single submitter ⚠
- p.Arg385His Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg477Leu Single submitter ⚠
- p.Arg519Lys Single submitter ⚠
- p.Arg553Cys Single submitter ⚠
- p.Arg553Gly Single submitter ⚠
- p.Arg664Gln Single submitter ⚠
- p.Asn107Ser Single submitter ⚠
- p.Asn238Asp Single submitter ⚠
- p.Asn23Asp Single submitter ⚠
- p.Asn543Ser Single submitter ⚠
- p.Asn662Thr Single submitter ⚠
- p.Asn92Lys Single submitter ⚠
- p.Asp128Asn Single submitter ⚠
- p.Asp246Asn Single submitter ⚠
- p.Asp401Tyr Single submitter ⚠
- p.Cys580Ser Single submitter ⚠
- p.Cys595Tyr Single submitter ⚠
- p.Gln514Arg Single submitter ⚠
- p.Glu192Asp Single submitter ⚠
- p.Glu353Gly Single submitter ⚠
- p.Glu400Asp Single submitter ⚠
- p.Gly280Arg Single submitter ⚠
- p.Gly554Ser Single submitter ⚠
- p.Gly737Ser Single submitter ⚠
- p.Ile225Thr Single submitter ⚠
- p.Ile225Val Single submitter ⚠
- p.Ile332Leu Single submitter ⚠
- p.Ile340Phe Single submitter ⚠
- p.Ile349Met Single submitter ⚠
- p.Ile377Met Single submitter ⚠
- p.Ile421Thr Single submitter ⚠
- p.Ile496Lys Single submitter ⚠
- p.Ile728Leu Single submitter ⚠
- p.Ile851Met Single submitter ⚠
- p.Leu532Ser Single submitter ⚠
- p.Leu634Phe Single submitter ⚠
- p.Lys117Met Single submitter ⚠
- p.Lys203Glu Single submitter ⚠
- p.Met200Val Single submitter ⚠
- p.Met243Ile Single submitter ⚠
- p.Met243Thr Single submitter ⚠
- p.Met304Val Single submitter ⚠
- p.Met404Leu Single submitter ⚠
- p.Met5Val Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Met88Val Single submitter ⚠
- p.Phe162Leu Single submitter ⚠
- p.Phe815Leu Single submitter ⚠
- p.Pro178Leu Single submitter ⚠
- p.Pro398Leu Single submitter ⚠
- p.Pro441Ser Single submitter ⚠
- p.Pro491Arg Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Pro764Ala Single submitter ⚠
- p.Ser115Pro Single submitter ⚠
- p.Ser26Leu Single submitter ⚠
- p.Ser412Pro Single submitter ⚠
- p.Ser443Asn Single submitter ⚠
- p.Ser478Phe Single submitter ⚠
- p.Ser558Cys Single submitter ⚠
- p.Thr147Ile Single submitter ⚠
- p.Thr326Ala Single submitter ⚠
- p.Thr52Asn Single submitter ⚠
- p.Trp221Cys Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val343Ile Single submitter ⚠
- p.Val515Ile Single submitter ⚠
- p.Val542Ile Single submitter ⚠