Sugi Variant

Sugi Variant/DPP9

DPP9 — 172 ClinVar variants

All ClinVar germline DPP9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →

2 Pathogenic · 2 Likely pathogenic · 3 Conflicting · 4 Benign · 2 Benign/Likely benign · 20 Likely benign · 139 Uncertain significance

Full DPP9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 131

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 67

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 62

The independent predictors disagree with each other — read with care.

All DPP9 variants

Pathogenic 2

  • p.Arg111Ter No assertion criteria hatipoglu immunodeficiency syndrome
  • p.Gln851Ter No assertion criteria hatipoglu immunodeficiency syndrome

Likely pathogenic 2

  • p.Arg828Cys Single submitter hatipoglu immunodeficiency syndrome
  • p.Met726Ile Single submitter Susceptibility to severe COVID-19

Conflicting classifications of pathogenicity 3

Benign 4

Benign/Likely benign 2

Likely benign 20

Uncertain significance 139