DPPA3 — 30 ClinVar variants
All ClinVar germline DPPA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
3 Likely benign · 27 Uncertain significance
Full DPPA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPPA3 p.Ala147Val Uncertain significance Single submitter
- DPPA3 p.Arg62Gly Uncertain significance Single submitter
- DPPA3 p.Arg83Gly Uncertain significance Single submitter
- DPPA3 p.Asn116Asp Uncertain significance Single submitter
- DPPA3 p.Asn151Ser Uncertain significance Single submitter
- DPPA3 p.Gln158Arg Uncertain significance Single submitter
- DPPA3 p.Glu64Ala Uncertain significance Single submitter
- DPPA3 p.Gly105Asp Uncertain significance Single submitter
- DPPA3 p.Gly105Ser Uncertain significance Single submitter
- DPPA3 p.Leu56Val Uncertain significance Single submitter
- DPPA3 p.Leu60Val Uncertain significance Single submitter
- DPPA3 p.Leu61Pro Uncertain significance Single submitter
- DPPA3 p.Pro128Ser Uncertain significance Single submitter
- DPPA3 p.Pro55Ala Uncertain significance Single submitter
- DPPA3 p.Ser23Pro Uncertain significance Single submitter
- DPPA3 p.Thr36Arg Uncertain significance Single submitter
- DPPA3 p.Val53Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DPPA3 p.Arg108Cys Uncertain significance Single submitter
- DPPA3 p.Arg24Trp Uncertain significance Single submitter
- DPPA3 p.Arg98Ser Uncertain significance Single submitter
- DPPA3 p.Glu35Lys Uncertain significance Single submitter
- DPPA3 p.Glu77Ala Uncertain significance Single submitter
- DPPA3 p.Ser14Tyr Uncertain significance Single submitter
- DPPA3 p.Ser23Cys Uncertain significance Single submitter
- DPPA3 p.Ser54Phe Uncertain significance Single submitter
- DPPA3 p.Trp141Arg Uncertain significance Single submitter
- DPPA3 p.Val137Met Uncertain significance Single submitter
All DPPA3 variants
Likely benign 3
- p.Glu64Gln Single submitter
- p.Lys95Arg Single submitter
- p.Ser57Pro Single submitter
Uncertain significance 27
- p.Ala147Val Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg24Trp Single submitter ⚠
- p.Arg62Gly Single submitter ⚠
- p.Arg83Gly Single submitter ⚠
- p.Arg98Ser Single submitter ⚠
- p.Asn116Asp Single submitter ⚠
- p.Asn151Ser Single submitter ⚠
- p.Gln158Arg Single submitter ⚠
- p.Glu35Lys Single submitter ⚠
- p.Glu64Ala Single submitter ⚠
- p.Glu77Ala Single submitter ⚠
- p.Gly105Asp Single submitter ⚠
- p.Gly105Ser Single submitter ⚠
- p.Leu56Val Single submitter ⚠
- p.Leu60Val Single submitter ⚠
- p.Leu61Pro Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro55Ala Single submitter ⚠
- p.Ser14Tyr Single submitter ⚠
- p.Ser23Cys Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Ser54Phe Single submitter ⚠
- p.Thr36Arg Single submitter ⚠
- p.Trp141Arg Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val53Leu Single submitter ⚠