DPRX — 33 ClinVar variants
All ClinVar germline DPRX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Pathogenic · 2 Likely benign · 30 Uncertain significance
Full DPRX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPRX p.Ala104Glu Uncertain significance Single submitter
- DPRX p.Ala173Thr Uncertain significance Single submitter
- DPRX p.Arg189Gln Uncertain significance Single submitter
- DPRX p.Arg189Gly Uncertain significance Single submitter
- DPRX p.Arg8Cys Uncertain significance Single submitter
- DPRX p.Asn103Asp Uncertain significance Single submitter
- DPRX p.Asn112Asp Uncertain significance Single submitter
- DPRX p.Gly93Val Uncertain significance Single submitter
- DPRX p.His17Gln Uncertain significance Single submitter
- DPRX p.Ile145Thr Uncertain significance Single submitter
- DPRX p.Ile33Val Uncertain significance Single submitter
- DPRX p.Leu7Phe Uncertain significance Single submitter
- DPRX p.Phe144Ile Uncertain significance Single submitter
- DPRX p.Phe64Leu Uncertain significance Single submitter
- DPRX p.Pro174Leu Uncertain significance Single submitter
- DPRX p.Pro57Ser Uncertain significance Single submitter
- DPRX p.Ser175Gly Uncertain significance Single submitter
- DPRX p.Ser44Arg Uncertain significance Single submitter
- DPRX p.Ser96Pro Uncertain significance Single submitter
- DPRX p.Thr85Ile Uncertain significance Single submitter
- DPRX p.Trp63Cys Uncertain significance Single submitter
- DPRX p.Tyr40His Uncertain significance Single submitter
- DPRX p.Val95Phe Uncertain significance Single submitter
- DPRX p.Val99Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DPRX p.Gly146Ser Uncertain significance Single submitter
- DPRX p.Ile53Thr Uncertain significance Single submitter
- DPRX p.Leu110Trp Uncertain significance Single submitter
- DPRX p.Leu28Gln Uncertain significance Single submitter
- DPRX p.Pro135Ser Uncertain significance Single submitter
- DPRX p.Thr122Met Uncertain significance Single submitter
All DPRX variants
Pathogenic 1
- p.Arg156Ter No assertion criteria Short stature
Likely benign 2
- p.Arg156Gln Single submitter
- p.Gly100Ser Single submitter
Uncertain significance 30
- p.Ala104Glu Single submitter ⚠
- p.Ala173Thr Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg189Gly Single submitter ⚠
- p.Arg8Cys Single submitter ⚠
- p.Asn103Asp Single submitter ⚠
- p.Asn112Asp Single submitter ⚠
- p.Gly146Ser Single submitter ⚠
- p.Gly93Val Single submitter ⚠
- p.His17Gln Single submitter ⚠
- p.Ile145Thr Single submitter ⚠
- p.Ile33Val Single submitter ⚠
- p.Ile53Thr Single submitter ⚠
- p.Leu110Trp Single submitter ⚠
- p.Leu28Gln Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Phe144Ile Single submitter ⚠
- p.Phe64Leu Single submitter ⚠
- p.Pro135Ser Single submitter ⚠
- p.Pro174Leu Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Ser175Gly Single submitter ⚠
- p.Ser44Arg Single submitter ⚠
- p.Ser96Pro Single submitter ⚠
- p.Thr122Met Single submitter ⚠
- p.Thr85Ile Single submitter ⚠
- p.Trp63Cys Single submitter ⚠
- p.Tyr40His Single submitter ⚠
- p.Val95Phe Single submitter ⚠
- p.Val99Ala Single submitter ⚠