DPY19L1 — 77 ClinVar variants
All ClinVar germline DPY19L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
2 Likely benign · 75 Uncertain significance
Full DPY19L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPY19L1 p.Ala386Val Uncertain significance Single submitter
- DPY19L1 p.Ala397Ser Uncertain significance Single submitter
- DPY19L1 p.Arg119His Uncertain significance Single submitter
- DPY19L1 p.Arg177Ser Uncertain significance Single submitter
- DPY19L1 p.Arg22Pro Uncertain significance Single submitter
- DPY19L1 p.Arg258Gln Uncertain significance Single submitter
- DPY19L1 p.Arg478Ser Uncertain significance Single submitter
- DPY19L1 p.Asn598Ser Uncertain significance Single submitter
- DPY19L1 p.Asn713Ser Uncertain significance Single submitter
- DPY19L1 p.Cys354Tyr Uncertain significance Single submitter
- DPY19L1 p.Gln588Pro Uncertain significance Single submitter
- DPY19L1 p.Gln596His Uncertain significance Single submitter
- DPY19L1 p.Glu8Asp Uncertain significance Single submitter
- DPY19L1 p.Gly260Arg Uncertain significance Single submitter
- DPY19L1 p.His110Tyr Uncertain significance Single submitter
- DPY19L1 p.Ile111Val Uncertain significance Single submitter
- DPY19L1 p.Ile202Val Uncertain significance Single submitter
- DPY19L1 p.Ile219Val Uncertain significance Single submitter
- DPY19L1 p.Ile353Arg Uncertain significance Single submitter
- DPY19L1 p.Ile362Met Uncertain significance Single submitter
- DPY19L1 p.Ile660Val Uncertain significance Single submitter
- DPY19L1 p.Leu369His Uncertain significance Single submitter
- DPY19L1 p.Leu485Pro Uncertain significance Single submitter
- DPY19L1 p.Leu489Phe Uncertain significance Single submitter
- DPY19L1 p.Leu564Val Uncertain significance Single submitter
- DPY19L1 p.Lys571Arg Uncertain significance Single submitter
- DPY19L1 p.Met161Lys Uncertain significance Single submitter
- DPY19L1 p.Met364Leu Uncertain significance Single submitter
- DPY19L1 p.Met364Val Uncertain significance Single submitter
- DPY19L1 p.Met542Ile Uncertain significance Single submitter
- DPY19L1 p.Pro11Ala Uncertain significance Single submitter
- DPY19L1 p.Pro13Arg Uncertain significance Single submitter
- DPY19L1 p.Ser387Ala Uncertain significance Single submitter
- DPY19L1 p.Thr480Ser Uncertain significance Single submitter
- DPY19L1 p.Thr512Ser Uncertain significance Single submitter
- DPY19L1 p.Trp208Arg Uncertain significance Single submitter
- DPY19L1 p.Val105Ala Uncertain significance Single submitter
- DPY19L1 p.Val157Ile Uncertain significance Single submitter
- DPY19L1 p.Val235Ala Uncertain significance Single submitter
- DPY19L1 p.Val300Gly Uncertain significance Single submitter
- DPY19L1 p.Val390Ile Uncertain significance Single submitter
- DPY19L1 p.Val600Ile Uncertain significance Single submitter
- DPY19L1 p.Val724Met Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- DPY19L1 p.Ala132Val Uncertain significance Single submitter
- DPY19L1 p.Ala340Val Uncertain significance Single submitter
- DPY19L1 p.Arg14Cys Uncertain significance Single submitter
- DPY19L1 p.Arg26Lys Uncertain significance Single submitter
- DPY19L1 p.Arg357Trp Uncertain significance Single submitter
- DPY19L1 p.Arg667Gln Uncertain significance Single submitter
- DPY19L1 p.Arg695Ile Uncertain significance Single submitter
- DPY19L1 p.Arg695Ser Uncertain significance Single submitter
- DPY19L1 p.Glu613Val Uncertain significance Single submitter
- DPY19L1 p.Glu672Lys Uncertain significance Single submitter
- DPY19L1 p.Gly213Val Uncertain significance Single submitter
- DPY19L1 p.Gly349Glu Uncertain significance Single submitter
- DPY19L1 p.Gly653Ala Uncertain significance Single submitter
- DPY19L1 p.Ile147Thr Uncertain significance Single submitter
- DPY19L1 p.Leu403Pro Uncertain significance Single submitter
- DPY19L1 p.Leu485Phe Uncertain significance Single submitter
- DPY19L1 p.Leu606Phe Uncertain significance Single submitter
- DPY19L1 p.Leu677Val Uncertain significance Single submitter
- DPY19L1 p.Lys308Gln Uncertain significance Single submitter
- DPY19L1 p.Lys455Met Uncertain significance Single submitter
- DPY19L1 p.Lys716Asn Uncertain significance Single submitter
- DPY19L1 p.Met379Val Uncertain significance Single submitter
- DPY19L1 p.Met585Val Uncertain significance Single submitter
- DPY19L1 p.Phe569Leu Uncertain significance Single submitter
- DPY19L1 p.Pro12Ser Uncertain significance Single submitter
- DPY19L1 p.Pro228Leu Uncertain significance Single submitter
- DPY19L1 p.Trp413Arg Uncertain significance Single submitter
- DPY19L1 p.Val263Leu Uncertain significance Single submitter
- DPY19L1 p.Val488Ile Uncertain significance Single submitter
- DPY19L1 p.Val578Ala Uncertain significance Single submitter
- DPY19L1 p.Val600Leu Uncertain significance Single submitter
- DPY19L1 p.Val739Ile Uncertain significance Single submitter
All DPY19L1 variants
Likely benign 2
- p.Arg675Gln Single submitter
- p.Val493Ile Single submitter
Uncertain significance 75
- p.Ala132Val Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala386Val Single submitter ⚠
- p.Ala397Ser Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg14Cys Single submitter ⚠
- p.Arg177Ser Single submitter ⚠
- p.Arg22Pro Single submitter ⚠
- p.Arg258Gln Single submitter ⚠
- p.Arg26Lys Single submitter ⚠
- p.Arg357Trp Single submitter ⚠
- p.Arg478Ser Single submitter ⚠
- p.Arg667Gln Single submitter ⚠
- p.Arg695Ile Single submitter ⚠
- p.Arg695Ser Single submitter ⚠
- p.Asn598Ser Single submitter ⚠
- p.Asn713Ser Single submitter ⚠
- p.Cys354Tyr Single submitter ⚠
- p.Gln588Pro Single submitter ⚠
- p.Gln596His Single submitter ⚠
- p.Glu613Val Single submitter ⚠
- p.Glu672Lys Single submitter ⚠
- p.Glu8Asp Single submitter ⚠
- p.Gly213Val Single submitter ⚠
- p.Gly260Arg Single submitter ⚠
- p.Gly349Glu Single submitter ⚠
- p.Gly653Ala Single submitter ⚠
- p.His110Tyr Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile147Thr Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile219Val Single submitter ⚠
- p.Ile353Arg Single submitter ⚠
- p.Ile362Met Single submitter ⚠
- p.Ile660Val Single submitter ⚠
- p.Leu369His Single submitter ⚠
- p.Leu403Pro Single submitter ⚠
- p.Leu485Phe Single submitter ⚠
- p.Leu485Pro Single submitter ⚠
- p.Leu489Phe Single submitter ⚠
- p.Leu564Val Single submitter ⚠
- p.Leu606Phe Single submitter ⚠
- p.Leu677Val Single submitter ⚠
- p.Lys308Gln Single submitter ⚠
- p.Lys455Met Single submitter ⚠
- p.Lys571Arg Single submitter ⚠
- p.Lys716Asn Single submitter ⚠
- p.Met161Lys Single submitter ⚠
- p.Met364Leu Single submitter ⚠
- p.Met364Val Single submitter ⚠
- p.Met379Val Single submitter ⚠
- p.Met542Ile Single submitter ⚠
- p.Met585Val Single submitter ⚠
- p.Phe569Leu Single submitter ⚠
- p.Pro11Ala Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro13Arg Single submitter ⚠
- p.Pro228Leu Single submitter ⚠
- p.Ser387Ala Single submitter ⚠
- p.Thr480Ser Single submitter ⚠
- p.Thr512Ser Single submitter ⚠
- p.Trp208Arg Single submitter ⚠
- p.Trp413Arg Single submitter ⚠
- p.Val105Ala Single submitter ⚠
- p.Val157Ile Single submitter ⚠
- p.Val235Ala Single submitter ⚠
- p.Val263Leu Single submitter ⚠
- p.Val300Gly Single submitter ⚠
- p.Val390Ile Single submitter ⚠
- p.Val488Ile Single submitter ⚠
- p.Val578Ala Single submitter ⚠
- p.Val600Ile Single submitter ⚠
- p.Val600Leu Single submitter ⚠
- p.Val724Met Single submitter ⚠
- p.Val739Ile Single submitter ⚠