DPY19L3 — 85 ClinVar variants
All ClinVar germline DPY19L3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
3 Likely benign · 82 Uncertain significance
Full DPY19L3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPY19L3 p.Ala192Thr Uncertain significance Single submitter
- DPY19L3 p.Ala464Thr Uncertain significance Single submitter
- DPY19L3 p.Ala54Ser Uncertain significance Single submitter
- DPY19L3 p.Arg654Gln Uncertain significance Single submitter
- DPY19L3 p.Asn339Ser Uncertain significance Single submitter
- DPY19L3 p.Asn715Lys Uncertain significance Single submitter
- DPY19L3 p.Cys36Phe Uncertain significance Single submitter
- DPY19L3 p.Gln109His Uncertain significance Single submitter
- DPY19L3 p.Glu622Val Uncertain significance Single submitter
- DPY19L3 p.Gly662Asp Uncertain significance Single submitter
- DPY19L3 p.Gly669Glu Uncertain significance Single submitter
- DPY19L3 p.Ile302Val Uncertain significance Single submitter
- DPY19L3 p.Ile361Val Uncertain significance Single submitter
- DPY19L3 p.Ile4Leu Uncertain significance Single submitter
- DPY19L3 p.Ile520Val Uncertain significance Single submitter
- DPY19L3 p.Ile614Met Uncertain significance Single submitter
- DPY19L3 p.Leu180Pro Uncertain significance Single submitter
- DPY19L3 p.Leu180Val Uncertain significance Single submitter
- DPY19L3 p.Leu656Val Uncertain significance Single submitter
- DPY19L3 p.Lys27Arg Uncertain significance Single submitter
- DPY19L3 p.Lys27Glu Uncertain significance Single submitter
- DPY19L3 p.Lys369Arg Uncertain significance Single submitter
- DPY19L3 p.Lys538Glu Uncertain significance Single submitter
- DPY19L3 p.Lys617Arg Uncertain significance Single submitter
- DPY19L3 p.Met265Val Uncertain significance Single submitter
- DPY19L3 p.Met280Leu Uncertain significance Single submitter
- DPY19L3 p.Met280Val Uncertain significance Single submitter
- DPY19L3 p.Met309Ile Uncertain significance Single submitter
- DPY19L3 p.Met350Thr Uncertain significance Single submitter
- DPY19L3 p.Met523Val Uncertain significance Single submitter
- DPY19L3 p.Met543Thr Uncertain significance Single submitter
- DPY19L3 p.Met579Leu Uncertain significance Single submitter
- DPY19L3 p.Met665Arg Uncertain significance Single submitter
- DPY19L3 p.Phe139Leu Uncertain significance Single submitter
- DPY19L3 p.Phe357Leu Uncertain significance Single submitter
- DPY19L3 p.Phe433Cys Uncertain significance Single submitter
- DPY19L3 p.Phe575Ser Uncertain significance Single submitter
- DPY19L3 p.Pro218Arg Uncertain significance Single submitter
- DPY19L3 p.Pro517Leu Uncertain significance Single submitter
- DPY19L3 p.Ser448Pro Uncertain significance Single submitter
- DPY19L3 p.Ser603Asn Uncertain significance Single submitter
- DPY19L3 p.Thr13Ala Uncertain significance Single submitter
- DPY19L3 p.Thr287Ile Uncertain significance Single submitter
- DPY19L3 p.Thr444Lys Uncertain significance Single submitter
- DPY19L3 p.Thr463Ala Uncertain significance Single submitter
- DPY19L3 p.Thr589Met Uncertain significance Single submitter
- DPY19L3 p.Tyr612His Uncertain significance Single submitter
- DPY19L3 p.Tyr94Cys Uncertain significance Single submitter
- DPY19L3 p.Val108Leu Uncertain significance Single submitter
- DPY19L3 p.Val434Ile Uncertain significance Single submitter
- DPY19L3 p.Val635Ile Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- DPY19L3 p.Ala173Gly Uncertain significance Single submitter
- DPY19L3 p.Ala495Thr Uncertain significance Single submitter
- DPY19L3 p.Ala576Val Uncertain significance Single submitter
- DPY19L3 p.Ala583Ser Uncertain significance Single submitter
- DPY19L3 p.Arg232Thr Uncertain significance Single submitter
- DPY19L3 p.Arg648Cys Uncertain significance Single submitter
- DPY19L3 p.Arg649Gln Uncertain significance Single submitter
- DPY19L3 p.Arg682His Uncertain significance Single submitter
- DPY19L3 p.Asp389Asn Uncertain significance Single submitter
- DPY19L3 p.Gly113Cys Uncertain significance Single submitter
- DPY19L3 p.Gly662Ser Uncertain significance Single submitter
- DPY19L3 p.Ile468Met Uncertain significance Single submitter
- DPY19L3 p.Ile471Ser Uncertain significance Single submitter
- DPY19L3 p.Ile504Lys Uncertain significance Single submitter
- DPY19L3 p.Leu32Trp Uncertain significance Single submitter
- DPY19L3 p.Leu440Phe Uncertain significance Single submitter
- DPY19L3 p.Leu627Val Uncertain significance Single submitter
- DPY19L3 p.Met309Val Uncertain significance Single submitter
- DPY19L3 p.Pro541Leu Uncertain significance Single submitter
- DPY19L3 p.Pro692Leu Uncertain significance Single submitter
- DPY19L3 p.Ser317Gly Uncertain significance Single submitter
- DPY19L3 p.Ser336Asn Likely benign Single submitter
- DPY19L3 p.Ser603Arg Uncertain significance Single submitter
- DPY19L3 p.Thr125Ile Uncertain significance Single submitter
- DPY19L3 p.Thr162Ala Uncertain significance Single submitter
- DPY19L3 p.Thr428Ile Uncertain significance Single submitter
- DPY19L3 p.Thr488Met Uncertain significance Single submitter
- DPY19L3 p.Thr589Ala Uncertain significance Single submitter
- DPY19L3 p.Tyr515Cys Uncertain significance Single submitter
- DPY19L3 p.Tyr537His Uncertain significance Single submitter
- DPY19L3 p.Val351Ile Uncertain significance Single submitter
- DPY19L3 p.Val574Met Uncertain significance Single submitter
All DPY19L3 variants
Likely benign 3
- p.Ser336Asn Single submitter ⚠
- p.Val108Met Single submitter
- p.Val695Met Single submitter
Uncertain significance 82
- p.Ala173Gly Single submitter ⚠
- p.Ala192Thr Single submitter ⚠
- p.Ala464Thr Single submitter ⚠
- p.Ala495Thr Single submitter ⚠
- p.Ala54Ser Single submitter ⚠
- p.Ala576Val Single submitter ⚠
- p.Ala583Ser Single submitter ⚠
- p.Arg232Thr Single submitter ⚠
- p.Arg648Cys Single submitter ⚠
- p.Arg649Gln Single submitter ⚠
- p.Arg654Gln Single submitter ⚠
- p.Arg682His Single submitter ⚠
- p.Asn339Ser Single submitter ⚠
- p.Asn715Lys Single submitter ⚠
- p.Asp389Asn Single submitter ⚠
- p.Cys36Phe Single submitter ⚠
- p.Gln109His Single submitter ⚠
- p.Glu622Val Single submitter ⚠
- p.Gly113Cys Single submitter ⚠
- p.Gly662Asp Single submitter ⚠
- p.Gly662Ser Single submitter ⚠
- p.Gly669Glu Single submitter ⚠
- p.Ile302Val Single submitter ⚠
- p.Ile361Val Single submitter ⚠
- p.Ile468Met Single submitter ⚠
- p.Ile471Ser Single submitter ⚠
- p.Ile4Leu Single submitter ⚠
- p.Ile504Lys Single submitter ⚠
- p.Ile520Val Single submitter ⚠
- p.Ile614Met Single submitter ⚠
- p.Leu180Pro Single submitter ⚠
- p.Leu180Val Single submitter ⚠
- p.Leu32Trp Single submitter ⚠
- p.Leu440Phe Single submitter ⚠
- p.Leu627Val Single submitter ⚠
- p.Leu656Val Single submitter ⚠
- p.Lys27Arg Single submitter ⚠
- p.Lys27Glu Single submitter ⚠
- p.Lys369Arg Single submitter ⚠
- p.Lys538Glu Single submitter ⚠
- p.Lys617Arg Single submitter ⚠
- p.Met265Val Single submitter ⚠
- p.Met280Leu Single submitter ⚠
- p.Met280Val Single submitter ⚠
- p.Met309Ile Single submitter ⚠
- p.Met309Val Single submitter ⚠
- p.Met350Thr Single submitter ⚠
- p.Met523Val Single submitter ⚠
- p.Met543Thr Single submitter ⚠
- p.Met579Leu Single submitter ⚠
- p.Met665Arg Single submitter ⚠
- p.Phe139Leu Single submitter ⚠
- p.Phe357Leu Single submitter ⚠
- p.Phe433Cys Single submitter ⚠
- p.Phe575Ser Single submitter ⚠
- p.Pro218Arg Single submitter ⚠
- p.Pro517Leu Single submitter ⚠
- p.Pro541Leu Single submitter ⚠
- p.Pro692Leu Single submitter ⚠
- p.Ser317Gly Single submitter ⚠
- p.Ser448Pro Single submitter ⚠
- p.Ser603Arg Single submitter ⚠
- p.Ser603Asn Single submitter ⚠
- p.Thr125Ile Single submitter ⚠
- p.Thr13Ala Single submitter ⚠
- p.Thr162Ala Single submitter ⚠
- p.Thr287Ile Single submitter ⚠
- p.Thr428Ile Single submitter ⚠
- p.Thr444Lys Single submitter ⚠
- p.Thr463Ala Single submitter ⚠
- p.Thr488Met Single submitter ⚠
- p.Thr589Ala Single submitter ⚠
- p.Thr589Met Single submitter ⚠
- p.Tyr515Cys Single submitter ⚠
- p.Tyr537His Single submitter ⚠
- p.Tyr612His Single submitter ⚠
- p.Tyr94Cys Single submitter ⚠
- p.Val108Leu Single submitter ⚠
- p.Val351Ile Single submitter ⚠
- p.Val434Ile Single submitter ⚠
- p.Val574Met Single submitter ⚠
- p.Val635Ile Single submitter ⚠