DPY19L4 — 84 ClinVar variants
All ClinVar germline DPY19L4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
1 Benign · 4 Likely benign · 79 Uncertain significance
Full DPY19L4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPY19L4 p.Arg516Gln Uncertain significance Single submitter
- DPY19L4 p.Arg573Gly Uncertain significance Single submitter
- DPY19L4 p.Asn375Ile Uncertain significance Single submitter
- DPY19L4 p.Asn707Lys Uncertain significance Single submitter
- DPY19L4 p.Asp105Glu Uncertain significance Single submitter
- DPY19L4 p.Asp607His Uncertain significance Single submitter
- DPY19L4 p.Cys356Tyr Uncertain significance Single submitter
- DPY19L4 p.Cys657Arg Uncertain significance Single submitter
- DPY19L4 p.Cys672Tyr Uncertain significance Single submitter
- DPY19L4 p.Gln438His Uncertain significance Single submitter
- DPY19L4 p.Glu311Asp Uncertain significance Single submitter
- DPY19L4 p.Glu38Lys Uncertain significance Single submitter
- DPY19L4 p.Glu4Gly Uncertain significance Single submitter
- DPY19L4 p.Glu552Gln Uncertain significance Single submitter
- DPY19L4 p.Gly115Asp Uncertain significance Single submitter
- DPY19L4 p.Gly193Glu Uncertain significance Single submitter
- DPY19L4 p.Gly55Ser Uncertain significance Single submitter
- DPY19L4 p.His372Leu Uncertain significance Single submitter
- DPY19L4 p.Ile131Val Uncertain significance Single submitter
- DPY19L4 p.Ile165Thr Uncertain significance Single submitter
- DPY19L4 p.Ile297Thr Uncertain significance Single submitter
- DPY19L4 p.Ile489Phe Uncertain significance Single submitter
- DPY19L4 p.Leu333Val Uncertain significance Single submitter
- DPY19L4 p.Leu511Phe Uncertain significance Single submitter
- DPY19L4 p.Lys623Gln Uncertain significance Single submitter
- DPY19L4 p.Lys691Asn Uncertain significance Single submitter
- DPY19L4 p.Met366Val Uncertain significance Single submitter
- DPY19L4 p.Met368Ile Uncertain significance Single submitter
- DPY19L4 p.Met396Val Uncertain significance Single submitter
- DPY19L4 p.Met481Leu Uncertain significance Single submitter
- DPY19L4 p.Met496Ile Uncertain significance Single submitter
- DPY19L4 p.Met531Val Uncertain significance Single submitter
- DPY19L4 p.Pro505Leu Uncertain significance Single submitter
- DPY19L4 p.Pro653Ser Uncertain significance Single submitter
- DPY19L4 p.Pro7Thr Uncertain significance Single submitter
- DPY19L4 p.Ser187Asn Uncertain significance Single submitter
- DPY19L4 p.Ser238Ile Uncertain significance Single submitter
- DPY19L4 p.Ser322Arg Uncertain significance Single submitter
- DPY19L4 p.Ser341Ile Uncertain significance Single submitter
- DPY19L4 p.Ser709Thr Uncertain significance Single submitter
- DPY19L4 p.Ser720Cys Uncertain significance Single submitter
- DPY19L4 p.Ser720Tyr Uncertain significance Single submitter
- DPY19L4 p.Thr196Pro Uncertain significance Single submitter
- DPY19L4 p.Thr208Arg Uncertain significance Single submitter
- DPY19L4 p.Thr208Ile Uncertain significance Single submitter
- DPY19L4 p.Thr395Ala Uncertain significance Single submitter
- DPY19L4 p.Thr454Ser Uncertain significance Single submitter
- DPY19L4 p.Thr569Asn Uncertain significance Single submitter
- DPY19L4 p.Trp508Ser Uncertain significance Single submitter
- DPY19L4 p.Tyr164Cys Uncertain significance Single submitter
- DPY19L4 p.Tyr700Cys Uncertain significance Single submitter
- DPY19L4 p.Val337Ala Uncertain significance Single submitter
- DPY19L4 p.Val671Ala Uncertain significance Single submitter
- DPY19L4 p.Val704Ile Uncertain significance Single submitter
- DPY19L4 p.Val712Ala Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- DPY19L4 p.Ala230Val Uncertain significance Single submitter
- DPY19L4 p.Ala579Val Uncertain significance Single submitter
- DPY19L4 p.Ala582Val Uncertain significance Single submitter
- DPY19L4 p.Ala590Val Likely benign Single submitter
- DPY19L4 p.Arg463Gly Uncertain significance Single submitter
- DPY19L4 p.Arg613Lys Uncertain significance Single submitter
- DPY19L4 p.Arg76Trp Uncertain significance Single submitter
- DPY19L4 p.Asp607Val Uncertain significance Single submitter
- DPY19L4 p.Gln586Arg Uncertain significance Single submitter
- DPY19L4 p.Glu118Gln Uncertain significance Single submitter
- DPY19L4 p.Gly153Asp Uncertain significance Single submitter
- DPY19L4 p.Ile460Thr Uncertain significance Single submitter
- DPY19L4 p.Leu250Ser Uncertain significance Single submitter
- DPY19L4 p.Leu476Trp Uncertain significance Single submitter
- DPY19L4 p.Met106Thr Uncertain significance Single submitter
- DPY19L4 p.Phe310Cys Uncertain significance Single submitter
- DPY19L4 p.Phe413Leu Uncertain significance Single submitter
- DPY19L4 p.Ser284Pro Uncertain significance Single submitter
- DPY19L4 p.Ser404Tyr Uncertain significance Single submitter
- DPY19L4 p.Thr208Ala Uncertain significance Single submitter
- DPY19L4 p.Tyr292Cys Uncertain significance Single submitter
- DPY19L4 p.Tyr295Cys Uncertain significance Single submitter
- DPY19L4 p.Tyr618His Uncertain significance Single submitter
- DPY19L4 p.Tyr69Cys Uncertain significance Single submitter
- DPY19L4 p.Val718Glu Uncertain significance Single submitter
All DPY19L4 variants
Benign 1
- c.1633-9del Single submitter
Likely benign 4
- c.871-7A>C Single submitter
- p.Ala590Val Single submitter ⚠
- p.Tyr102= Single submitter
- p.Val317Leu Single submitter
Uncertain significance 79
- p.Ala230Val Single submitter ⚠
- p.Ala579Val Single submitter ⚠
- p.Ala582Val Single submitter ⚠
- p.Arg463Gly Single submitter ⚠
- p.Arg516Gln Single submitter ⚠
- p.Arg573Gly Single submitter ⚠
- p.Arg613Lys Single submitter ⚠
- p.Arg76Trp Single submitter ⚠
- p.Asn375Ile Single submitter ⚠
- p.Asn707Lys Single submitter ⚠
- p.Asp105Glu Single submitter ⚠
- p.Asp607His Single submitter ⚠
- p.Asp607Val Single submitter ⚠
- p.Cys356Tyr Single submitter ⚠
- p.Cys657Arg Single submitter ⚠
- p.Cys672Tyr Single submitter ⚠
- p.Gln438His Single submitter ⚠
- p.Gln586Arg Single submitter ⚠
- p.Glu118Gln Single submitter ⚠
- p.Glu311Asp Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Glu4Gly Single submitter ⚠
- p.Glu552Gln Single submitter ⚠
- p.Gly115Asp Single submitter ⚠
- p.Gly153Asp Single submitter ⚠
- p.Gly193Glu Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.His372Leu Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile165Thr Single submitter ⚠
- p.Ile297Thr Single submitter ⚠
- p.Ile460Thr Single submitter ⚠
- p.Ile489Phe Single submitter ⚠
- p.Leu250Ser Single submitter ⚠
- p.Leu333Val Single submitter ⚠
- p.Leu476Trp Single submitter ⚠
- p.Leu511Phe Single submitter ⚠
- p.Lys623Gln Single submitter ⚠
- p.Lys691Asn Single submitter ⚠
- p.Met106Thr Single submitter ⚠
- p.Met366Val Single submitter ⚠
- p.Met368Ile Single submitter ⚠
- p.Met396Val Single submitter ⚠
- p.Met481Leu Single submitter ⚠
- p.Met496Ile Single submitter ⚠
- p.Met531Val Single submitter ⚠
- p.Phe310Cys Single submitter ⚠
- p.Phe413Leu Single submitter ⚠
- p.Pro505Leu Single submitter ⚠
- p.Pro653Ser Single submitter ⚠
- p.Pro7Thr Single submitter ⚠
- p.Ser187Asn Single submitter ⚠
- p.Ser238Ile Single submitter ⚠
- p.Ser284Pro Single submitter ⚠
- p.Ser322Arg Single submitter ⚠
- p.Ser341Ile Single submitter ⚠
- p.Ser404Tyr Single submitter ⚠
- p.Ser709Thr Single submitter ⚠
- p.Ser720Cys Single submitter ⚠
- p.Ser720Tyr Single submitter ⚠
- p.Thr196Pro Single submitter ⚠
- p.Thr208Ala Single submitter ⚠
- p.Thr208Arg Single submitter ⚠
- p.Thr208Ile Single submitter ⚠
- p.Thr395Ala Single submitter ⚠
- p.Thr454Ser Single submitter ⚠
- p.Thr569Asn Single submitter ⚠
- p.Trp508Ser Single submitter ⚠
- p.Tyr164Cys Single submitter ⚠
- p.Tyr292Cys Single submitter ⚠
- p.Tyr295Cys Single submitter ⚠
- p.Tyr618His Single submitter ⚠
- p.Tyr69Cys Single submitter ⚠
- p.Tyr700Cys Single submitter ⚠
- p.Val337Ala Single submitter ⚠
- p.Val671Ala Single submitter ⚠
- p.Val704Ile Single submitter ⚠
- p.Val712Ala Single submitter ⚠
- p.Val718Glu Single submitter ⚠