DPY30 — 5 ClinVar variants
All ClinVar germline DPY30 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
5 Uncertain significance
Full DPY30 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All DPY30 variants
Uncertain significance 5
- p.Ala85Val Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.His18Pro Single submitter ⚠
- p.Phe95Ser Single submitter ⚠
- p.Val31Leu Single submitter ⚠