DPYSL4 — 104 ClinVar variants
All ClinVar germline DPYSL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
4 Likely benign · 100 Uncertain significance
Full DPYSL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DPYSL4 p.Ala130Glu Uncertain significance Single submitter
- DPYSL4 p.Ala442Val Uncertain significance Single submitter
- DPYSL4 p.Ala520Thr Uncertain significance Single submitter
- DPYSL4 p.Ala546Asp Uncertain significance Single submitter
- DPYSL4 p.Arg11Gln Uncertain significance Single submitter
- DPYSL4 p.Arg126Trp Uncertain significance Single submitter
- DPYSL4 p.Arg173Trp Uncertain significance Single submitter
- DPYSL4 p.Arg269His Uncertain significance Single submitter
- DPYSL4 p.Arg487Lys Uncertain significance Single submitter
- DPYSL4 p.Arg496Cys Uncertain significance Single submitter
- DPYSL4 p.Arg496His Uncertain significance Single submitter
- DPYSL4 p.Arg519His Uncertain significance Single submitter
- DPYSL4 p.Asp28Asn Uncertain significance Single submitter
- DPYSL4 p.Asp87Glu Uncertain significance Single submitter
- DPYSL4 p.Cys319Gly Uncertain significance Single submitter
- DPYSL4 p.Gly493Asp Uncertain significance Single submitter
- DPYSL4 p.Gly501Arg Uncertain significance Single submitter
- DPYSL4 p.His333Arg Uncertain significance Single submitter
- DPYSL4 p.Ile433Val Uncertain significance Single submitter
- DPYSL4 p.Ile447Leu Uncertain significance Single submitter
- DPYSL4 p.Ile45Val Uncertain significance Single submitter
- DPYSL4 p.Ile526Thr Uncertain significance Single submitter
- DPYSL4 p.Leu534Arg Uncertain significance Single submitter
- DPYSL4 p.Leu81Met Uncertain significance Single submitter
- DPYSL4 p.Lys254Arg Uncertain significance Single submitter
- DPYSL4 p.Lys254Thr Uncertain significance Single submitter
- DPYSL4 p.Met168Ile Uncertain significance Single submitter
- DPYSL4 p.Met181Ile Uncertain significance Single submitter
- DPYSL4 p.Phe348Leu Uncertain significance Single submitter
- DPYSL4 p.Phe394Val Uncertain significance Single submitter
- DPYSL4 p.Pro309Ala Uncertain significance Single submitter
- DPYSL4 p.Pro309Ser Uncertain significance Single submitter
- DPYSL4 p.Pro523Ser Uncertain significance Single submitter
- DPYSL4 p.Ser129Thr Uncertain significance Single submitter
- DPYSL4 p.Ser385Arg Uncertain significance Single submitter
- DPYSL4 p.Thr318Ile Uncertain significance Single submitter
- DPYSL4 p.Val37Met Uncertain significance Single submitter
Predictors split 63
The independent predictors disagree with each other — read with care.
- DPYSL4 p.Ala127Gly Uncertain significance Single submitter
- DPYSL4 p.Ala300Thr Uncertain significance Single submitter
- DPYSL4 p.Ala349Val Uncertain significance Single submitter
- DPYSL4 p.Ala382Thr Uncertain significance Single submitter
- DPYSL4 p.Ala489Val Uncertain significance Single submitter
- DPYSL4 p.Arg124Trp Uncertain significance Single submitter
- DPYSL4 p.Arg16Cys Uncertain significance Single submitter
- DPYSL4 p.Arg16His Uncertain significance Single submitter
- DPYSL4 p.Arg211Gln Uncertain significance Single submitter
- DPYSL4 p.Arg269Cys Uncertain significance Single submitter
- DPYSL4 p.Arg440Gln Uncertain significance Single submitter
- DPYSL4 p.Arg440Trp Uncertain significance Single submitter
- DPYSL4 p.Arg471Gln Uncertain significance Single submitter
- DPYSL4 p.Arg553His Uncertain significance Single submitter
- DPYSL4 p.Arg565His Uncertain significance Single submitter
- DPYSL4 p.Asn426Ser Uncertain significance Single submitter
- DPYSL4 p.Asp111Asn Uncertain significance Single submitter
- DPYSL4 p.Asp128Glu Uncertain significance Single submitter
- DPYSL4 p.Asp262Asn Uncertain significance Single submitter
- DPYSL4 p.Asp286Asn Uncertain significance Single submitter
- DPYSL4 p.Asp315His Uncertain significance Single submitter
- DPYSL4 p.Asp88Asn Uncertain significance Single submitter
- DPYSL4 p.Gln180Arg Uncertain significance Single submitter
- DPYSL4 p.Gln209Glu Uncertain significance Single submitter
- DPYSL4 p.Glu208Gly Uncertain significance Single submitter
- DPYSL4 p.Glu353Lys Uncertain significance Single submitter
- DPYSL4 p.Glu455Gln Uncertain significance Single submitter
- DPYSL4 p.Gly202Ala Uncertain significance Single submitter
- DPYSL4 p.Gly216Ser Uncertain significance Single submitter
- DPYSL4 p.Gly287Ser Uncertain significance Single submitter
- DPYSL4 p.Gly324Arg Uncertain significance Single submitter
- DPYSL4 p.Gly457Arg Uncertain significance Single submitter
- DPYSL4 p.Gly493Ser Uncertain significance Single submitter
- DPYSL4 p.Ile217Leu Uncertain significance Single submitter
- DPYSL4 p.Ile419Phe Uncertain significance Single submitter
- DPYSL4 p.Leu350Met Uncertain significance Single submitter
- DPYSL4 p.Lys293Glu Uncertain significance Single submitter
- DPYSL4 p.Lys390Arg Uncertain significance Single submitter
- DPYSL4 p.Met103Thr Uncertain significance Single submitter
- DPYSL4 p.Met168Val Uncertain significance Single submitter
- DPYSL4 p.Met256Thr Uncertain significance Single submitter
- DPYSL4 p.Phe185Leu Uncertain significance Single submitter
- DPYSL4 p.Pro463Leu Uncertain significance Single submitter
- DPYSL4 p.Pro517Leu Uncertain significance Single submitter
- DPYSL4 p.Pro529Leu Uncertain significance Single submitter
- DPYSL4 p.Ser282Cys Uncertain significance Single submitter
- DPYSL4 p.Ser363Leu Uncertain significance Single submitter
- DPYSL4 p.Ser372Phe Uncertain significance Single submitter
- DPYSL4 p.Ser521Cys Uncertain significance Single submitter
- DPYSL4 p.Ser544Phe Uncertain significance Single submitter
- DPYSL4 p.Thr13Met Uncertain significance Single submitter
- DPYSL4 p.Thr313Met Uncertain significance Single submitter
- DPYSL4 p.Thr335Ile Uncertain significance Single submitter
- DPYSL4 p.Tyr170Cys Uncertain significance Single submitter
- DPYSL4 p.Val156Gly Uncertain significance Single submitter
- DPYSL4 p.Val205Met Uncertain significance Single submitter
- DPYSL4 p.Val231Ala Uncertain significance Single submitter
- DPYSL4 p.Val231Met Uncertain significance Single submitter
- DPYSL4 p.Val445Met Uncertain significance Single submitter
- DPYSL4 p.Val503Ile Uncertain significance Single submitter
- DPYSL4 p.Val508Met Uncertain significance Single submitter
- DPYSL4 p.Val51Ile Uncertain significance Single submitter
- DPYSL4 p.Val531Met Uncertain significance Single submitter
All DPYSL4 variants
Likely benign 4
- p.Ala263Val Single submitter
- p.Ala516Thr Single submitter
- p.Lys415Arg Single submitter
- p.Ser323= Single submitter
Uncertain significance 100
- p.Ala127Gly Single submitter ⚠
- p.Ala130Glu Single submitter ⚠
- p.Ala300Thr Single submitter ⚠
- p.Ala349Val Single submitter ⚠
- p.Ala382Thr Single submitter ⚠
- p.Ala442Val Single submitter ⚠
- p.Ala489Val Single submitter ⚠
- p.Ala520Thr Single submitter ⚠
- p.Ala546Asp Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg124Trp Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg16Cys Single submitter ⚠
- p.Arg16His Single submitter ⚠
- p.Arg173Trp Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg440Gln Single submitter ⚠
- p.Arg440Trp Single submitter ⚠
- p.Arg471Gln Single submitter ⚠
- p.Arg487Lys Single submitter ⚠
- p.Arg496Cys Single submitter ⚠
- p.Arg496His Single submitter ⚠
- p.Arg519His Single submitter ⚠
- p.Arg553His Single submitter ⚠
- p.Arg565His Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Asp128Glu Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp286Asn Single submitter ⚠
- p.Asp28Asn Single submitter ⚠
- p.Asp315His Single submitter ⚠
- p.Asp87Glu Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Cys319Gly Single submitter ⚠
- p.Gln180Arg Single submitter ⚠
- p.Gln209Glu Single submitter ⚠
- p.Glu208Gly Single submitter ⚠
- p.Glu353Lys Single submitter ⚠
- p.Glu455Gln Single submitter ⚠
- p.Gly202Ala Single submitter ⚠
- p.Gly216Ser Single submitter ⚠
- p.Gly287Ser Single submitter ⚠
- p.Gly324Arg Single submitter ⚠
- p.Gly457Arg Single submitter ⚠
- p.Gly493Asp Single submitter ⚠
- p.Gly493Ser Single submitter ⚠
- p.Gly501Arg Single submitter ⚠
- p.His333Arg Single submitter ⚠
- p.Ile217Leu Single submitter ⚠
- p.Ile419Phe Single submitter ⚠
- p.Ile433Val Single submitter ⚠
- p.Ile447Leu Single submitter ⚠
- p.Ile45Val Single submitter ⚠
- p.Ile526Thr Single submitter ⚠
- p.Leu350Met Single submitter ⚠
- p.Leu534Arg Single submitter ⚠
- p.Leu81Met Single submitter ⚠
- p.Lys254Arg Single submitter ⚠
- p.Lys254Thr Single submitter ⚠
- p.Lys293Glu Single submitter ⚠
- p.Lys390Arg Single submitter ⚠
- p.Met103Thr Single submitter ⚠
- p.Met168Ile Single submitter ⚠
- p.Met168Val Single submitter ⚠
- p.Met181Ile Single submitter ⚠
- p.Met256Thr Single submitter ⚠
- p.Phe185Leu Single submitter ⚠
- p.Phe348Leu Single submitter ⚠
- p.Phe394Val Single submitter ⚠
- p.Pro309Ala Single submitter ⚠
- p.Pro309Ser Single submitter ⚠
- p.Pro463Leu Single submitter ⚠
- p.Pro517Leu Single submitter ⚠
- p.Pro523Ser Single submitter ⚠
- p.Pro529Leu Single submitter ⚠
- p.Ser129Thr Single submitter ⚠
- p.Ser282Cys Single submitter ⚠
- p.Ser363Leu Single submitter ⚠
- p.Ser372Phe Single submitter ⚠
- p.Ser385Arg Single submitter ⚠
- p.Ser521Cys Single submitter ⚠
- p.Ser544Phe Single submitter ⚠
- p.Thr13Met Single submitter ⚠
- p.Thr313Met Single submitter ⚠
- p.Thr318Ile Single submitter ⚠
- p.Thr335Ile Single submitter ⚠
- p.Tyr170Cys Single submitter ⚠
- p.Val156Gly Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val231Ala Single submitter ⚠
- p.Val231Met Single submitter ⚠
- p.Val37Met Single submitter ⚠
- p.Val445Met Single submitter ⚠
- p.Val503Ile Single submitter ⚠
- p.Val508Met Single submitter ⚠
- p.Val51Ile Single submitter ⚠
- p.Val531Met Single submitter ⚠