DR1 — 6 ClinVar variants
All ClinVar germline DR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
6 Uncertain significance
Full DR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All DR1 variants
Uncertain significance 6
- p.Asn41Ser Single submitter ⚠
- p.Asp175Gly Single submitter ⚠
- p.Ile50Val Single submitter ⚠
- p.Ile66Met Single submitter ⚠
- p.Ile84Asn Single submitter ⚠
- p.Ser82Pro Single submitter ⚠