DRAP1 — 25 ClinVar variants
All ClinVar germline DRAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Benign · 1 Likely benign · 23 Uncertain significance
Full DRAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRAP1 p.Asn100Asp Uncertain significance Single submitter
- DRAP1 p.Asp130Glu Uncertain significance Single submitter
- DRAP1 p.Glu198Asp Uncertain significance Single submitter
- DRAP1 p.His69Tyr Uncertain significance Single submitter
- DRAP1 p.Leu177Pro Uncertain significance Single submitter
- DRAP1 p.Leu185Phe Uncertain significance Single submitter
- DRAP1 p.Leu44Phe Uncertain significance Single submitter
- DRAP1 p.Met124Thr Uncertain significance Single submitter
- DRAP1 p.Pro172Leu Uncertain significance Single submitter
- DRAP1 p.Thr149Ser Uncertain significance Single submitter
- DRAP1 p.Thr174Pro Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DRAP1 p.Arg109Cys Uncertain significance Single submitter
- DRAP1 p.Arg112Trp Uncertain significance Single submitter
- DRAP1 p.Asp105His Uncertain significance Single submitter
- DRAP1 p.Asp196Asn Uncertain significance Single submitter
- DRAP1 p.Gln55His Uncertain significance Single submitter
- DRAP1 p.Glu200Lys Uncertain significance Single submitter
- DRAP1 p.Gly111Asp Uncertain significance Single submitter
- DRAP1 p.Lys4Gln Uncertain significance Single submitter
- DRAP1 p.Pro114Ser Uncertain significance Single submitter
- DRAP1 p.Pro184Leu Uncertain significance Single submitter
- DRAP1 p.Pro190Leu Uncertain significance Single submitter
- DRAP1 p.Pro2Arg Uncertain significance Single submitter
All DRAP1 variants
Benign 1
- p.Arg16= Single submitter
Likely benign 1
- p.Ala180Thr Single submitter
Uncertain significance 23
- p.Arg109Cys Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Asn100Asp Single submitter ⚠
- p.Asp105His Single submitter ⚠
- p.Asp130Glu Single submitter ⚠
- p.Asp196Asn Single submitter ⚠
- p.Gln55His Single submitter ⚠
- p.Glu198Asp Single submitter ⚠
- p.Glu200Lys Single submitter ⚠
- p.Gly111Asp Single submitter ⚠
- p.His69Tyr Single submitter ⚠
- p.Leu177Pro Single submitter ⚠
- p.Leu185Phe Single submitter ⚠
- p.Leu44Phe Single submitter ⚠
- p.Lys4Gln Single submitter ⚠
- p.Met124Thr Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro172Leu Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Thr149Ser Single submitter ⚠
- p.Thr174Pro Single submitter ⚠