DRAXIN — 48 ClinVar variants
All ClinVar germline DRAXIN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 6 Likely benign · 40 Uncertain significance
Full DRAXIN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRAXIN p.Ala9Ser Uncertain significance Single submitter
- DRAXIN p.Arg125Gln Uncertain significance Single submitter
- DRAXIN p.Arg135Ser Uncertain significance Single submitter
- DRAXIN p.Arg152Gln Uncertain significance Single submitter
- DRAXIN p.Arg256His Uncertain significance Single submitter
- DRAXIN p.Arg329Lys Uncertain significance Single submitter
- DRAXIN p.Arg58His Uncertain significance Single submitter
- DRAXIN p.Arg59Gln Uncertain significance Single submitter
- DRAXIN p.Arg60Gln Uncertain significance Single submitter
- DRAXIN p.Asp110Gly Uncertain significance Single submitter
- DRAXIN p.Asp144Asn Uncertain significance Single submitter
- DRAXIN p.Asp287Asn Uncertain significance Single submitter
- DRAXIN p.Glu121Lys Uncertain significance Single submitter
- DRAXIN p.Glu166Gln Uncertain significance Single submitter
- DRAXIN p.Glu202Val Uncertain significance Single submitter
- DRAXIN p.Gly114Val Uncertain significance Single submitter
- DRAXIN p.Gly245Asp Uncertain significance Single submitter
- DRAXIN p.Gly263Asp Uncertain significance Single submitter
- DRAXIN p.Gly271Arg Uncertain significance Single submitter
- DRAXIN p.Gly271Glu Uncertain significance Single submitter
- DRAXIN p.Leu259Pro Uncertain significance Single submitter
- DRAXIN p.Met177Lys Uncertain significance Single submitter
- DRAXIN p.Met309Thr Uncertain significance Single submitter
- DRAXIN p.Pro186Ser Uncertain significance Single submitter
- DRAXIN p.Pro282Ser Uncertain significance Single submitter
- DRAXIN p.Pro72Arg Uncertain significance Single submitter
- DRAXIN p.Ser267Leu Uncertain significance Single submitter
- DRAXIN p.Thr284Ser Uncertain significance Single submitter
- DRAXIN p.Thr338Met Uncertain significance Single submitter
- DRAXIN p.Thr51Met Uncertain significance Single submitter
- DRAXIN p.Thr84Ile Uncertain significance Single submitter
- DRAXIN p.Tyr317Cys Uncertain significance Single submitter
- DRAXIN p.Tyr317Phe Uncertain significance Single submitter
- DRAXIN p.Val172Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DRAXIN p.Arg58Cys Uncertain significance Single submitter
- DRAXIN p.Asp306Asn Uncertain significance Single submitter
- DRAXIN p.Gly299Arg Uncertain significance Single submitter
- DRAXIN p.His291Asn Uncertain significance Single submitter
- DRAXIN p.Thr227Met Uncertain significance Single submitter
- DRAXIN p.Thr294Pro Uncertain significance Single submitter
All DRAXIN variants
Benign 2
- p.Gly222Arg Multiple submitters
- p.Lys64= Single submitter
Likely benign 6
- c.937+6T>A Single submitter
- p.Arg60Trp Single submitter
- p.Gly257Ser Single submitter
- p.Pro33Ser Single submitter
- p.Pro62= Single submitter
- p.Pro62Leu Single submitter
Uncertain significance 40
- p.Ala9Ser Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg135Ser Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Arg329Lys Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Arg59Gln Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Asp110Gly Single submitter ⚠
- p.Asp144Asn Single submitter ⚠
- p.Asp287Asn Single submitter ⚠
- p.Asp306Asn Single submitter ⚠
- p.Glu121Lys Single submitter ⚠
- p.Glu166Gln Single submitter ⚠
- p.Glu202Val Single submitter ⚠
- p.Gly114Val Single submitter ⚠
- p.Gly245Asp Single submitter ⚠
- p.Gly263Asp Single submitter ⚠
- p.Gly271Arg Single submitter ⚠
- p.Gly271Glu Single submitter ⚠
- p.Gly299Arg Single submitter ⚠
- p.His291Asn Single submitter ⚠
- p.Leu259Pro Single submitter ⚠
- p.Met177Lys Single submitter ⚠
- p.Met309Thr Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Pro72Arg Single submitter ⚠
- p.Ser267Leu Single submitter ⚠
- p.Thr227Met Single submitter ⚠
- p.Thr284Ser Single submitter ⚠
- p.Thr294Pro Single submitter ⚠
- p.Thr338Met Single submitter ⚠
- p.Thr51Met Single submitter ⚠
- p.Thr84Ile Single submitter ⚠
- p.Tyr317Cys Single submitter ⚠
- p.Tyr317Phe Single submitter ⚠
- p.Val172Leu Single submitter ⚠