DRC12 — 26 ClinVar variants
All ClinVar germline DRC12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Likely benign · 24 Uncertain significance
Full DRC12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 20
The independent predictors disagree with each other — read with care.
- DRC12 p.Ala123Pro Uncertain significance Single submitter
- DRC12 p.Ala140Gly Uncertain significance Single submitter
- DRC12 p.Ala140Pro Uncertain significance Single submitter
- DRC12 p.Arg113Leu Uncertain significance Single submitter
- DRC12 p.Arg113Pro Uncertain significance Single submitter
- DRC12 p.Arg127Trp Uncertain significance Single submitter
- DRC12 p.Arg137Gln Uncertain significance Single submitter
- DRC12 p.Arg137Trp Uncertain significance Single submitter
- DRC12 p.Arg145Trp Uncertain significance Single submitter
- DRC12 p.Arg193Cys Likely benign Single submitter
- DRC12 p.Arg53Cys Uncertain significance Single submitter
- DRC12 p.Arg53His Uncertain significance Single submitter
- DRC12 p.Arg89Cys Uncertain significance Single submitter
- DRC12 p.Glu190Lys Uncertain significance Single submitter
- DRC12 p.Glu28Lys Uncertain significance Single submitter
- DRC12 p.Glu59Lys Uncertain significance Single submitter
- DRC12 p.Gly114Val Uncertain significance Single submitter
- DRC12 p.Leu197Pro Uncertain significance Single submitter
- DRC12 p.Pro199His Uncertain significance Single submitter
- DRC12 p.Val109Gly Uncertain significance Single submitter
All DRC12 variants
Likely benign 2
- p.Arg193Cys Single submitter ⚠
- p.Gly135Arg Single submitter
Uncertain significance 24
- p.Ala123Pro Single submitter ⚠
- p.Ala140Gly Single submitter ⚠
- p.Ala140Pro Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Arg113Leu Single submitter ⚠
- p.Arg113Pro Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg137Trp Single submitter ⚠
- p.Arg145Trp Single submitter ⚠
- p.Arg53Cys Single submitter ⚠
- p.Arg53His Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu28Lys Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly114Val Single submitter ⚠
- p.Leu197Pro Single submitter ⚠
- p.Met98Thr Single submitter ⚠
- p.Pro199His Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro200Thr Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val109Gly Single submitter ⚠