DRC3 — 90 ClinVar variants
All ClinVar germline DRC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
8 Likely benign · 82 Uncertain significance
Full DRC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRC3 p.Ala221Thr Uncertain significance Single submitter
- DRC3 p.Ala228Val Uncertain significance Single submitter
- DRC3 p.Arg120Gln Uncertain significance Single submitter
- DRC3 p.Arg191Gln Uncertain significance Single submitter
- DRC3 p.Arg385Thr Uncertain significance Single submitter
- DRC3 p.Arg496His Uncertain significance Single submitter
- DRC3 p.Asn397Thr Uncertain significance Single submitter
- DRC3 p.Asn438Lys Uncertain significance Single submitter
- DRC3 p.Asn438Ser Uncertain significance Single submitter
- DRC3 p.Asn477Lys Uncertain significance Single submitter
- DRC3 p.Asn54Ser Uncertain significance Single submitter
- DRC3 p.Asp16His Uncertain significance Single submitter
- DRC3 p.Asp303Asn Uncertain significance Single submitter
- DRC3 p.Asp507Asn Uncertain significance Single submitter
- DRC3 p.Asp520Asn Uncertain significance Single submitter
- DRC3 p.Cys284Ser Uncertain significance Single submitter
- DRC3 p.Cys308Arg Uncertain significance Single submitter
- DRC3 p.Gln399Arg Uncertain significance Single submitter
- DRC3 p.Glu202Gln Uncertain significance Single submitter
- DRC3 p.Glu224Asp Uncertain significance Single submitter
- DRC3 p.Glu328Lys Uncertain significance Single submitter
- DRC3 p.Glu425Gln Uncertain significance Single submitter
- DRC3 p.Glu512Lys Uncertain significance Single submitter
- DRC3 p.Gly139Asp Uncertain significance Single submitter
- DRC3 p.Gly32Arg Uncertain significance Single submitter
- DRC3 p.Gly82Val Uncertain significance Single submitter
- DRC3 p.Ile283Leu Uncertain significance Single submitter
- DRC3 p.Ile283Val Uncertain significance Single submitter
- DRC3 p.Ile347Val Uncertain significance Single submitter
- DRC3 p.Ile387Val Uncertain significance Single submitter
- DRC3 p.Ile421Val Uncertain significance Single submitter
- DRC3 p.Ile427Met Uncertain significance Single submitter
- DRC3 p.Ile55Val Uncertain significance Single submitter
- DRC3 p.Leu218Val Uncertain significance Single submitter
- DRC3 p.Leu463Val Uncertain significance Single submitter
- DRC3 p.Lys489Asn Uncertain significance Single submitter
- DRC3 p.Met17Ile Uncertain significance Single submitter
- DRC3 p.Met253Ile Uncertain significance Single submitter
- DRC3 p.Met366Lys Uncertain significance Single submitter
- DRC3 p.Phe177Leu Uncertain significance Single submitter
- DRC3 p.Thr160Met Uncertain significance Single submitter
- DRC3 p.Val131Ile Uncertain significance Single submitter
- DRC3 p.Val22Ile Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- DRC3 p.Ala201Val Uncertain significance Single submitter
- DRC3 p.Ala239Thr Uncertain significance Single submitter
- DRC3 p.Arg142Trp Uncertain significance Single submitter
- DRC3 p.Arg192Cys Uncertain significance Single submitter
- DRC3 p.Arg192His Uncertain significance Single submitter
- DRC3 p.Arg230Trp Uncertain significance Single submitter
- DRC3 p.Arg298Gln Uncertain significance Single submitter
- DRC3 p.Arg298Trp Uncertain significance Single submitter
- DRC3 p.Arg406Gln Uncertain significance Single submitter
- DRC3 p.Arg475Ile Uncertain significance Single submitter
- DRC3 p.Arg482Cys Uncertain significance Single submitter
- DRC3 p.Arg496Cys Uncertain significance Single submitter
- DRC3 p.Arg498Cys Uncertain significance Single submitter
- DRC3 p.Arg53Trp Uncertain significance Single submitter
- DRC3 p.Asn477Thr Uncertain significance Single submitter
- DRC3 p.Asp210His Uncertain significance Single submitter
- DRC3 p.Asp363Gly Uncertain significance Single submitter
- DRC3 p.Glu172Lys Uncertain significance Single submitter
- DRC3 p.Glu256Lys Uncertain significance Single submitter
- DRC3 p.Glu341Gln Uncertain significance Single submitter
- DRC3 p.Gly139Cys Uncertain significance Single submitter
- DRC3 p.Gly268Arg Uncertain significance Single submitter
- DRC3 p.Gly430Asp Uncertain significance Single submitter
- DRC3 p.Ile102Val Uncertain significance Single submitter
- DRC3 p.Ile324Thr Uncertain significance Single submitter
- DRC3 p.Ile419Ser Uncertain significance Single submitter
- DRC3 p.Ile502Met Uncertain significance Single submitter
- DRC3 p.Ile58Val Uncertain significance Single submitter
- DRC3 p.Leu111Val Uncertain significance Single submitter
- DRC3 p.Lys323Asn Uncertain significance Single submitter
- DRC3 p.Lys69Glu Likely benign Single submitter
- DRC3 p.Met390Thr Uncertain significance Single submitter
- DRC3 p.Phe362Leu Uncertain significance Single submitter
- DRC3 p.Phe383Leu Uncertain significance Single submitter
- DRC3 p.Ser247Phe Uncertain significance Single submitter
- DRC3 p.Thr379Pro Uncertain significance Single submitter
- DRC3 p.Thr449Arg Uncertain significance Single submitter
- DRC3 p.Tyr276Cys Uncertain significance Single submitter
- DRC3 p.Val445Ala Uncertain significance Single submitter
- DRC3 p.Val90Leu Uncertain significance Single submitter
All DRC3 variants
Likely benign 8
- c.1326+15_1326+16insGGAGCATGTCGGGGAAGGGCTGGATGGAGTTGGACTGGGTGGGGAAGGGGCGGAGATGGGGCGGGGCGGGC Single submitter
- p.Arg310His Single submitter
- p.Asn438Asp Single submitter
- p.Asp363Asn Single submitter
- p.Gly455Arg Single submitter
- p.Lys69Glu Single submitter ⚠
- p.Pro4Leu Single submitter
- p.Ser7= Single submitter
Uncertain significance 82
- p.Ala201Val Single submitter ⚠
- p.Ala221Thr Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala239Thr Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg191Gln Single submitter ⚠
- p.Arg192Cys Single submitter ⚠
- p.Arg192His Single submitter ⚠
- p.Arg230Trp Single submitter ⚠
- p.Arg298Gln Single submitter ⚠
- p.Arg298Trp Single submitter ⚠
- p.Arg385Thr Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg475Ile Single submitter ⚠
- p.Arg482Cys Single submitter ⚠
- p.Arg496Cys Single submitter ⚠
- p.Arg496His Single submitter ⚠
- p.Arg498Cys Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Asn397Thr Single submitter ⚠
- p.Asn438Lys Single submitter ⚠
- p.Asn438Ser Single submitter ⚠
- p.Asn477Lys Single submitter ⚠
- p.Asn477Thr Single submitter ⚠
- p.Asn54Ser Single submitter ⚠
- p.Asp16His Single submitter ⚠
- p.Asp210His Single submitter ⚠
- p.Asp303Asn Single submitter ⚠
- p.Asp363Gly Single submitter ⚠
- p.Asp507Asn Single submitter ⚠
- p.Asp520Asn Single submitter ⚠
- p.Cys284Ser Single submitter ⚠
- p.Cys308Arg Single submitter ⚠
- p.Gln399Arg Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.Glu202Gln Single submitter ⚠
- p.Glu224Asp Single submitter ⚠
- p.Glu256Lys Single submitter ⚠
- p.Glu328Lys Single submitter ⚠
- p.Glu341Gln Single submitter ⚠
- p.Glu425Gln Single submitter ⚠
- p.Glu512Lys Single submitter ⚠
- p.Gly139Asp Single submitter ⚠
- p.Gly139Cys Single submitter ⚠
- p.Gly268Arg Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly430Asp Single submitter ⚠
- p.Gly82Val Single submitter ⚠
- p.Ile102Val Single submitter ⚠
- p.Ile283Leu Single submitter ⚠
- p.Ile283Val Single submitter ⚠
- p.Ile324Thr Single submitter ⚠
- p.Ile347Val Single submitter ⚠
- p.Ile387Val Single submitter ⚠
- p.Ile419Ser Single submitter ⚠
- p.Ile421Val Single submitter ⚠
- p.Ile427Met Single submitter ⚠
- p.Ile502Met Single submitter ⚠
- p.Ile55Val Single submitter ⚠
- p.Ile58Val Single submitter ⚠
- p.Leu111Val Single submitter ⚠
- p.Leu218Val Single submitter ⚠
- p.Leu463Val Single submitter ⚠
- p.Lys323Asn Single submitter ⚠
- p.Lys489Asn Single submitter ⚠
- p.Met17Ile Single submitter ⚠
- p.Met253Ile Single submitter ⚠
- p.Met366Lys Single submitter ⚠
- p.Met390Thr Single submitter ⚠
- p.Phe177Leu Single submitter ⚠
- p.Phe362Leu Single submitter ⚠
- p.Phe383Leu Single submitter ⚠
- p.Ser247Phe Single submitter ⚠
- p.Thr160Met Single submitter ⚠
- p.Thr379Pro Single submitter ⚠
- p.Thr449Arg Single submitter ⚠
- p.Tyr276Cys Single submitter ⚠
- p.Val131Ile Single submitter ⚠
- p.Val22Ile Single submitter ⚠
- p.Val445Ala Single submitter ⚠
- p.Val90Leu Single submitter ⚠