DRC7 — 139 ClinVar variants
All ClinVar germline DRC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →
3 Likely benign · 136 Uncertain significance
Full DRC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 137
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRC7 p.Ala65Val Uncertain significance Single submitter
- DRC7 p.Ala709Val Uncertain significance Single submitter
- DRC7 p.Ala769Val Uncertain significance Single submitter
- DRC7 p.Arg112His Uncertain significance Single submitter
- DRC7 p.Arg312His Uncertain significance Single submitter
- DRC7 p.Arg686Lys Uncertain significance Single submitter
- DRC7 p.Arg721Gln Uncertain significance Single submitter
- DRC7 p.Arg841Cys Uncertain significance Single submitter
- DRC7 p.Arg865Ser Uncertain significance Single submitter
- DRC7 p.Asp155Asn Uncertain significance Single submitter
- DRC7 p.Asp188Tyr Uncertain significance Single submitter
- DRC7 p.Asp219Gly Uncertain significance Single submitter
- DRC7 p.Asp321His Uncertain significance Single submitter
- DRC7 p.Asp390Asn Uncertain significance Single submitter
- DRC7 p.Asp390Gly Uncertain significance Single submitter
- DRC7 p.Asp73His Uncertain significance Single submitter
- DRC7 p.Asp863Gly Uncertain significance Single submitter
- DRC7 p.Cys470Tyr Uncertain significance Single submitter
- DRC7 p.Cys776Tyr Uncertain significance Single submitter
- DRC7 p.Cys828Arg Uncertain significance Single submitter
- DRC7 p.Gln260Arg Uncertain significance Single submitter
- DRC7 p.Gln520Lys Uncertain significance Single submitter
- DRC7 p.Glu15Lys Uncertain significance Single submitter
- DRC7 p.Glu17Ala Uncertain significance Single submitter
- DRC7 p.Glu21Lys Uncertain significance Single submitter
- DRC7 p.Glu289Lys Uncertain significance Single submitter
- DRC7 p.Glu339Lys Uncertain significance Single submitter
- DRC7 p.Glu522Asp Uncertain significance Single submitter
- DRC7 p.Glu775Asp Uncertain significance Single submitter
- DRC7 p.Glu819Lys Uncertain significance Single submitter
- DRC7 p.Glu91Gly Uncertain significance Single submitter
- DRC7 p.His621Asp Uncertain significance Single submitter
- DRC7 p.His687Arg Uncertain significance Single submitter
- DRC7 p.Ile393Val Uncertain significance Single submitter
- DRC7 p.Ile492Leu Uncertain significance Single submitter
- DRC7 p.Ile527Val Uncertain significance Single submitter
- DRC7 p.Leu108Pro Uncertain significance Single submitter
- DRC7 p.Leu193Phe Uncertain significance Single submitter
- DRC7 p.Leu575Pro Uncertain significance Single submitter
- DRC7 p.Leu702Val Uncertain significance Single submitter
- DRC7 p.Leu790Pro Uncertain significance Single submitter
- DRC7 p.Leu823Val Uncertain significance Single submitter
- DRC7 p.Leu848Met Uncertain significance Single submitter
- DRC7 p.Leu869Ile Uncertain significance Single submitter
- DRC7 p.Lys643Arg Uncertain significance Single submitter
- DRC7 p.Lys720Glu Uncertain significance Single submitter
- DRC7 p.Lys773Arg Uncertain significance Single submitter
- DRC7 p.Met832Thr Uncertain significance Single submitter
- DRC7 p.Pro250Leu Uncertain significance Single submitter
- DRC7 p.Pro250Thr Uncertain significance Single submitter
- DRC7 p.Pro251Arg Uncertain significance Single submitter
- DRC7 p.Pro505Thr Uncertain significance Single submitter
- DRC7 p.Ser170Leu Uncertain significance Single submitter
- DRC7 p.Thr324Ile Uncertain significance Single submitter
- DRC7 p.Thr464Ile Uncertain significance Single submitter
- DRC7 p.Thr719Asn Uncertain significance Single submitter
- DRC7 p.Trp22Ser Uncertain significance Single submitter
- DRC7 p.Tyr373Phe Uncertain significance Single submitter
- DRC7 p.Tyr516Ser Uncertain significance Single submitter
- DRC7 p.Tyr809Asp Uncertain significance Single submitter
- DRC7 p.Tyr861His Uncertain significance Single submitter
- DRC7 p.Val113Met Uncertain significance Single submitter
- DRC7 p.Val586Ala Uncertain significance Single submitter
Predictors split 74
The independent predictors disagree with each other — read with care.
- DRC7 p.Ala510Pro Uncertain significance Single submitter
- DRC7 p.Ala605Val Uncertain significance Single submitter
- DRC7 p.Ala629Thr Uncertain significance Single submitter
- DRC7 p.Arg103His Uncertain significance Single submitter
- DRC7 p.Arg134Trp Uncertain significance Single submitter
- DRC7 p.Arg16Gln Uncertain significance Single submitter
- DRC7 p.Arg16Trp Uncertain significance Single submitter
- DRC7 p.Arg222Gln Uncertain significance Single submitter
- DRC7 p.Arg222Trp Uncertain significance Single submitter
- DRC7 p.Arg277Trp Uncertain significance Single submitter
- DRC7 p.Arg300Gln Uncertain significance Single submitter
- DRC7 p.Arg300Trp Uncertain significance Single submitter
- DRC7 p.Arg38Trp Uncertain significance Single submitter
- DRC7 p.Arg431Cys Uncertain significance Single submitter
- DRC7 p.Arg431His Uncertain significance Single submitter
- DRC7 p.Arg461Cys Uncertain significance Single submitter
- DRC7 p.Arg461His Uncertain significance Single submitter
- DRC7 p.Arg512Cys Uncertain significance Single submitter
- DRC7 p.Arg512His Uncertain significance Single submitter
- DRC7 p.Arg525Cys Uncertain significance Single submitter
- DRC7 p.Arg525His Uncertain significance Single submitter
- DRC7 p.Arg534Cys Uncertain significance Single submitter
- DRC7 p.Arg534His Uncertain significance Single submitter
- DRC7 p.Arg541Gln Uncertain significance Single submitter
- DRC7 p.Arg555His Uncertain significance Single submitter
- DRC7 p.Arg583Gln Uncertain significance Single submitter
- DRC7 p.Arg583Trp Likely benign Single submitter
- DRC7 p.Arg607His Uncertain significance Single submitter
- DRC7 p.Arg734Cys Uncertain significance Single submitter
- DRC7 p.Arg734His Uncertain significance Single submitter
- DRC7 p.Arg742Trp Uncertain significance Single submitter
- DRC7 p.Arg771Cys Uncertain significance Single submitter
- DRC7 p.Arg771His Uncertain significance Single submitter
- DRC7 p.Arg783Gln Uncertain significance Single submitter
- DRC7 p.Arg794Cys Uncertain significance Single submitter
- DRC7 p.Arg834His Uncertain significance Single submitter
- DRC7 p.Asn456Lys Uncertain significance Single submitter
- DRC7 p.Asp332Asn Uncertain significance Single submitter
- DRC7 p.Asp779Asn Uncertain significance Single submitter
- DRC7 p.Gln267His Uncertain significance Single submitter
- DRC7 p.Gln671Arg Uncertain significance Single submitter
- DRC7 p.Glu142Lys Uncertain significance Single submitter
- DRC7 p.Glu283Asp Uncertain significance Single submitter
- DRC7 p.Glu36Gly Uncertain significance Single submitter
- DRC7 p.Glu396Gly Uncertain significance Single submitter
- DRC7 p.Glu633Asp Uncertain significance Single submitter
- DRC7 p.Glu658Lys Uncertain significance Single submitter
- DRC7 p.His334Tyr Uncertain significance Single submitter
- DRC7 p.His507Gln Uncertain significance Single submitter
- DRC7 p.Ile439Met Uncertain significance Single submitter
- DRC7 p.Ile585Thr Uncertain significance Single submitter
- DRC7 p.Leu179Phe Uncertain significance Single submitter
- DRC7 p.Leu365Val Uncertain significance Single submitter
- DRC7 p.Leu866Val Uncertain significance Single submitter
- DRC7 p.Lys183Glu Uncertain significance Single submitter
- DRC7 p.Lys240Asn Uncertain significance Single submitter
- DRC7 p.Lys359Thr Uncertain significance Single submitter
- DRC7 p.Met413Val Uncertain significance Single submitter
- DRC7 p.Met486Val Uncertain significance Single submitter
- DRC7 p.Met653Val Uncertain significance Single submitter
- DRC7 p.Phe558Leu Uncertain significance Single submitter
- DRC7 p.Pro322Thr Uncertain significance Single submitter
- DRC7 p.Pro451Leu Uncertain significance Single submitter
- DRC7 p.Pro599Arg Uncertain significance Single submitter
- DRC7 p.Ser174Cys Uncertain significance Single submitter
- DRC7 p.Ser175Leu Uncertain significance Single submitter
- DRC7 p.Thr221Met Uncertain significance Single submitter
- DRC7 p.Thr532Met Uncertain significance Single submitter
- DRC7 p.Tyr202Cys Uncertain significance Single submitter
- DRC7 p.Tyr328His Uncertain significance Single submitter
- DRC7 p.Tyr452His Uncertain significance Single submitter
- DRC7 p.Val160Met Uncertain significance Single submitter
- DRC7 p.Val207Ile Uncertain significance Single submitter
- DRC7 p.Val37Met Uncertain significance Single submitter
All DRC7 variants
Likely benign 3
- p.Arg583Trp Single submitter ⚠
- p.Lys275Glu Single submitter
- p.Val611Ile Single submitter
Uncertain significance 136
- p.Ala510Pro Single submitter ⚠
- p.Ala605Val Single submitter ⚠
- p.Ala629Thr Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala709Val Single submitter ⚠
- p.Ala769Val Single submitter ⚠
- p.Arg103His Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg16Gln Single submitter ⚠
- p.Arg16Trp Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg222Trp Single submitter ⚠
- p.Arg277Trp Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Arg300Trp Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Arg431Cys Single submitter ⚠
- p.Arg431His Single submitter ⚠
- p.Arg461Cys Single submitter ⚠
- p.Arg461His Single submitter ⚠
- p.Arg512Cys Single submitter ⚠
- p.Arg512His Single submitter ⚠
- p.Arg525Cys Single submitter ⚠
- p.Arg525His Single submitter ⚠
- p.Arg534Cys Single submitter ⚠
- p.Arg534His Single submitter ⚠
- p.Arg541Gln Single submitter ⚠
- p.Arg555His Single submitter ⚠
- p.Arg583Gln Single submitter ⚠
- p.Arg607His Single submitter ⚠
- p.Arg686Lys Single submitter ⚠
- p.Arg721Gln Single submitter ⚠
- p.Arg734Cys Single submitter ⚠
- p.Arg734His Single submitter ⚠
- p.Arg742Trp Single submitter ⚠
- p.Arg771Cys Single submitter ⚠
- p.Arg771His Single submitter ⚠
- p.Arg783Gln Single submitter ⚠
- p.Arg794Cys Single submitter ⚠
- p.Arg834His Single submitter ⚠
- p.Arg841Cys Single submitter ⚠
- p.Arg865Ser Single submitter ⚠
- p.Asn456Lys Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp188Tyr Single submitter ⚠
- p.Asp219Gly Single submitter ⚠
- p.Asp321His Single submitter ⚠
- p.Asp332Asn Single submitter ⚠
- p.Asp390Asn Single submitter ⚠
- p.Asp390Gly Single submitter ⚠
- p.Asp73His Single submitter ⚠
- p.Asp779Asn Single submitter ⚠
- p.Asp863Gly Single submitter ⚠
- p.Cys470Tyr Single submitter ⚠
- p.Cys776Tyr Single submitter ⚠
- p.Cys828Arg Single submitter ⚠
- p.Gln260Arg Single submitter ⚠
- p.Gln267His Single submitter ⚠
- p.Gln520Lys Single submitter ⚠
- p.Gln671Arg Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu15Lys Single submitter ⚠
- p.Glu17Ala Single submitter ⚠
- p.Glu21Lys Single submitter ⚠
- p.Glu283Asp Single submitter ⚠
- p.Glu289Lys Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Glu36Gly Single submitter ⚠
- p.Glu396Gly Single submitter ⚠
- p.Glu522Asp Single submitter ⚠
- p.Glu633Asp Single submitter ⚠
- p.Glu658Lys Single submitter ⚠
- p.Glu775Asp Single submitter ⚠
- p.Glu819Lys Single submitter ⚠
- p.Glu91Gly Single submitter ⚠
- p.His334Tyr Single submitter ⚠
- p.His507Gln Single submitter ⚠
- p.His621Asp Single submitter ⚠
- p.His687Arg Single submitter ⚠
- p.Ile393Val Single submitter ⚠
- p.Ile439Met Single submitter ⚠
- p.Ile492Leu Single submitter ⚠
- p.Ile527Val Single submitter ⚠
- p.Ile585Thr Single submitter ⚠
- p.Leu108Pro Single submitter ⚠
- p.Leu179Phe Single submitter ⚠
- p.Leu193Phe Single submitter ⚠
- p.Leu365Val Single submitter ⚠
- p.Leu575Pro Single submitter ⚠
- p.Leu702Val Single submitter ⚠
- p.Leu790Pro Single submitter ⚠
- p.Leu823Val Single submitter ⚠
- p.Leu848Met Single submitter ⚠
- p.Leu866Val Single submitter ⚠
- p.Leu869Ile Single submitter ⚠
- p.Lys183Glu Single submitter ⚠
- p.Lys240Asn Single submitter ⚠
- p.Lys359Thr Single submitter ⚠
- p.Lys643Arg Single submitter ⚠
- p.Lys720Glu Single submitter ⚠
- p.Lys773Arg Single submitter ⚠
- p.Met413Val Single submitter ⚠
- p.Met486Val Single submitter ⚠
- p.Met653Val Single submitter ⚠
- p.Met832Thr Single submitter ⚠
- p.Phe558Leu Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro250Thr Single submitter ⚠
- p.Pro251Arg Single submitter ⚠
- p.Pro322Thr Single submitter ⚠
- p.Pro451Leu Single submitter ⚠
- p.Pro505Thr Single submitter ⚠
- p.Pro599Arg Single submitter ⚠
- p.Ser170Leu Single submitter ⚠
- p.Ser174Cys Single submitter ⚠
- p.Ser175Leu Single submitter ⚠
- p.Thr221Met Single submitter ⚠
- p.Thr324Ile Single submitter ⚠
- p.Thr464Ile Single submitter ⚠
- p.Thr532Met Single submitter ⚠
- p.Thr719Asn Single submitter ⚠
- p.Trp22Ser Single submitter ⚠
- p.Tyr202Cys Single submitter ⚠
- p.Tyr328His Single submitter ⚠
- p.Tyr373Phe Single submitter ⚠
- p.Tyr452His Single submitter ⚠
- p.Tyr516Ser Single submitter ⚠
- p.Tyr809Asp Single submitter ⚠
- p.Tyr861His Single submitter ⚠
- p.Val113Met Single submitter ⚠
- p.Val160Met Single submitter ⚠
- p.Val207Ile Single submitter ⚠
- p.Val37Met Single submitter ⚠
- p.Val586Ala Single submitter ⚠