DRG2 — 53 ClinVar variants
All ClinVar germline DRG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
3 Benign · 1 Likely benign · 49 Uncertain significance
Full DRG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRG2 p.Ala135Ser Uncertain significance Single submitter
- DRG2 p.Ala137Val Uncertain significance Single submitter
- DRG2 p.Ala32Val Uncertain significance Single submitter
- DRG2 p.Ala35Thr Uncertain significance Single submitter
- DRG2 p.Ala63Val Uncertain significance Single submitter
- DRG2 p.Arg129His Uncertain significance Single submitter
- DRG2 p.Arg138Leu Uncertain significance Single submitter
- DRG2 p.Arg16Trp Uncertain significance Single submitter
- DRG2 p.Arg236Gln Uncertain significance Single submitter
- DRG2 p.Arg310Trp Uncertain significance Single submitter
- DRG2 p.Arg38Gln Uncertain significance Single submitter
- DRG2 p.Asp277Gly Uncertain significance Single submitter
- DRG2 p.Glu162Lys Uncertain significance Single submitter
- DRG2 p.Glu216Val Uncertain significance Single submitter
- DRG2 p.Glu255Lys Uncertain significance Single submitter
- DRG2 p.His208Tyr Uncertain significance Single submitter
- DRG2 p.Ile104Thr Uncertain significance Single submitter
- DRG2 p.Ile361Asn Uncertain significance Single submitter
- DRG2 p.Leu283Val Uncertain significance Single submitter
- DRG2 p.Leu67Arg Uncertain significance Single submitter
- DRG2 p.Met282Leu Uncertain significance Single submitter
- DRG2 p.Met353Val Uncertain significance Single submitter
- DRG2 p.Met82Ile Uncertain significance Single submitter
- DRG2 p.Ser199Pro Uncertain significance Single submitter
- DRG2 p.Ser252Pro Uncertain significance Single submitter
- DRG2 p.Ser343Ile Uncertain significance Single submitter
- DRG2 p.Thr150Ser Uncertain significance Single submitter
- DRG2 p.Thr23Ser Uncertain significance Single submitter
- DRG2 p.Thr98Met Uncertain significance Single submitter
- DRG2 p.Val244Ala Uncertain significance Single submitter
- DRG2 p.Val318Met Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- DRG2 p.Ala306Thr Uncertain significance Single submitter
- DRG2 p.Ala86Thr Uncertain significance Single submitter
- DRG2 p.Arg321Cys Uncertain significance Single submitter
- DRG2 p.Arg346Gln Uncertain significance Single submitter
- DRG2 p.Asn214Ser Uncertain significance Single submitter
- DRG2 p.Cys223Ser Uncertain significance Single submitter
- DRG2 p.Glu164Gln Uncertain significance Single submitter
- DRG2 p.His317Tyr Uncertain significance Single submitter
- DRG2 p.Ile143Val Likely benign Single submitter
- DRG2 p.Ile248Leu Uncertain significance Single submitter
- DRG2 p.Leu205Val Uncertain significance Single submitter
- DRG2 p.Met145Val Uncertain significance Single submitter
- DRG2 p.Phe228Leu Uncertain significance Single submitter
- DRG2 p.Pro225Leu Uncertain significance Single submitter
- DRG2 p.Ser328Arg Uncertain significance Single submitter
- DRG2 p.Ser47Leu Uncertain significance Single submitter
- DRG2 p.Ser49Leu Uncertain significance Single submitter
- DRG2 p.Val193Ile Benign Single submitter
- DRG2 p.Val203Leu Uncertain significance Single submitter
All DRG2 variants
Benign 3
- p.Ile359= Multiple submitters
- p.Ile229= Single submitter
- p.Val193Ile Single submitter ⚠
Likely benign 1
- p.Ile143Val Single submitter ⚠
Uncertain significance 49
- p.Ala135Ser Single submitter ⚠
- p.Ala137Val Single submitter ⚠
- p.Ala306Thr Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Ala86Thr Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg138Leu Single submitter ⚠
- p.Arg16Trp Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg310Trp Single submitter ⚠
- p.Arg321Cys Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg38Gln Single submitter ⚠
- p.Asn214Ser Single submitter ⚠
- p.Asp277Gly Single submitter ⚠
- p.Cys223Ser Single submitter ⚠
- p.Glu162Lys Single submitter ⚠
- p.Glu164Gln Single submitter ⚠
- p.Glu216Val Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.His208Tyr Single submitter ⚠
- p.His317Tyr Single submitter ⚠
- p.Ile104Thr Single submitter ⚠
- p.Ile248Leu Single submitter ⚠
- p.Ile361Asn Single submitter ⚠
- p.Leu205Val Single submitter ⚠
- p.Leu283Val Single submitter ⚠
- p.Leu67Arg Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Met282Leu Single submitter ⚠
- p.Met353Val Single submitter ⚠
- p.Met82Ile Single submitter ⚠
- p.Phe228Leu Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Ser199Pro Single submitter ⚠
- p.Ser252Pro Single submitter ⚠
- p.Ser328Arg Single submitter ⚠
- p.Ser343Ile Single submitter ⚠
- p.Ser47Leu Single submitter ⚠
- p.Ser49Leu Single submitter ⚠
- p.Thr150Ser Single submitter ⚠
- p.Thr23Ser Single submitter ⚠
- p.Thr98Met Single submitter ⚠
- p.Val203Leu Single submitter ⚠
- p.Val244Ala Single submitter ⚠
- p.Val318Met Single submitter ⚠
- c.315+9del No assertion criteria