DRICH1 — 35 ClinVar variants
All ClinVar germline DRICH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Likely benign · 34 Uncertain significance
Full DRICH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DRICH1 p.Ala21Thr Uncertain significance Single submitter
- DRICH1 p.Arg211Gln Uncertain significance Single submitter
- DRICH1 p.Arg75Cys Uncertain significance Single submitter
- DRICH1 p.Arg75His Uncertain significance Single submitter
- DRICH1 p.Asp20Asn Uncertain significance Single submitter
- DRICH1 p.Gly52Glu Uncertain significance Single submitter
- DRICH1 p.Gly56Asp Uncertain significance Single submitter
- DRICH1 p.Leu49Pro Uncertain significance Single submitter
- DRICH1 p.Lys79Thr Uncertain significance Single submitter
- DRICH1 p.Pro46Leu Uncertain significance Single submitter
- DRICH1 p.Pro97Arg Uncertain significance Single submitter
- DRICH1 p.Ser39Ala Uncertain significance Single submitter
- DRICH1 p.Thr209Ile Uncertain significance Single submitter
- DRICH1 p.Thr54Ala Uncertain significance Single submitter
- DRICH1 p.Trp15Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- DRICH1 p.Arg133Cys Uncertain significance Single submitter
- DRICH1 p.Arg159Gln Uncertain significance Single submitter
- DRICH1 p.Arg211Trp Uncertain significance Single submitter
- DRICH1 p.Asp125Ala Uncertain significance Single submitter
- DRICH1 p.Asp197Tyr Uncertain significance Single submitter
- DRICH1 p.Asp203Val Uncertain significance Single submitter
- DRICH1 p.Asp74His Uncertain significance Single submitter
- DRICH1 p.Cys8Tyr Uncertain significance Single submitter
- DRICH1 p.His61Asp Uncertain significance Single submitter
- DRICH1 p.Ile62Asn Uncertain significance Single submitter
- DRICH1 p.Lys79Asn Uncertain significance Single submitter
- DRICH1 p.Met67Ile Uncertain significance Single submitter
- DRICH1 p.Pro176Leu Uncertain significance Single submitter
- DRICH1 p.Ser132Pro Uncertain significance Single submitter
- DRICH1 p.Ser177Leu Uncertain significance Single submitter
- DRICH1 p.Ser220Arg Uncertain significance Single submitter
- DRICH1 p.Ser77Cys Uncertain significance Single submitter
- DRICH1 p.Thr54Met Uncertain significance Single submitter
- DRICH1 p.Thr69Pro Uncertain significance Single submitter
All DRICH1 variants
Likely benign 1
- p.His207= Single submitter
Uncertain significance 34
- p.Ala21Thr Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg211Trp Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg75His Single submitter ⚠
- p.Asp125Ala Single submitter ⚠
- p.Asp197Tyr Single submitter ⚠
- p.Asp203Val Single submitter ⚠
- p.Asp20Asn Single submitter ⚠
- p.Asp74His Single submitter ⚠
- p.Cys8Tyr Single submitter ⚠
- p.Gly52Glu Single submitter ⚠
- p.Gly56Asp Single submitter ⚠
- p.His61Asp Single submitter ⚠
- p.Ile62Asn Single submitter ⚠
- p.Leu49Pro Single submitter ⚠
- p.Lys79Asn Single submitter ⚠
- p.Lys79Thr Single submitter ⚠
- p.Met67Ile Single submitter ⚠
- p.Pro176Leu Single submitter ⚠
- p.Pro46Leu Single submitter ⚠
- p.Pro97Arg Single submitter ⚠
- p.Ser132Pro Single submitter ⚠
- p.Ser177Leu Single submitter ⚠
- p.Ser220Arg Single submitter ⚠
- p.Ser39Ala Single submitter ⚠
- p.Ser77Cys Single submitter ⚠
- p.Thr209Ile Single submitter ⚠
- p.Thr54Ala Single submitter ⚠
- p.Thr54Met Single submitter ⚠
- p.Thr69Pro Single submitter ⚠
- p.Trp15Leu Single submitter ⚠