DSC1 — 123 ClinVar variants
All ClinVar germline DSC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 119 flagged for review →
4 Benign · 1 Likely benign · 118 Uncertain significance
Full DSC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 119
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DSC1 p.Ala128Pro Uncertain significance Single submitter
- DSC1 p.Ala209Val Uncertain significance Single submitter
- DSC1 p.Ala221Glu Uncertain significance Single submitter
- DSC1 p.Ala239Thr Uncertain significance Single submitter
- DSC1 p.Ala574Thr Uncertain significance Single submitter
- DSC1 p.Ala693Val Uncertain significance Single submitter
- DSC1 p.Ala6Pro Uncertain significance Single submitter
- DSC1 p.Arg634Leu Uncertain significance Single submitter
- DSC1 p.Arg63Gln Uncertain significance Single submitter
- DSC1 p.Arg663Thr Uncertain significance Single submitter
- DSC1 p.Arg826Gln Uncertain significance Single submitter
- DSC1 p.Arg868Leu Uncertain significance Single submitter
- DSC1 p.Asn586Ser Uncertain significance Single submitter
- DSC1 p.Asn686Thr Uncertain significance Single submitter
- DSC1 p.Asn851Asp Uncertain significance Single submitter
- DSC1 p.Asp193Asn Uncertain significance Single submitter
- DSC1 p.Asp369Asn Uncertain significance Single submitter
- DSC1 p.Asp526His Uncertain significance Single submitter
- DSC1 p.Asp837Glu Uncertain significance Single submitter
- DSC1 p.Cys667Gly Uncertain significance Single submitter
- DSC1 p.Cys891Ser Uncertain significance Single submitter
- DSC1 p.Gln157Arg Uncertain significance Single submitter
- DSC1 p.Gln285Lys Uncertain significance Single submitter
- DSC1 p.Glu206Lys Uncertain significance Single submitter
- DSC1 p.Glu829Lys Uncertain significance Single submitter
- DSC1 p.Gly149Cys Uncertain significance Single submitter
- DSC1 p.Gly333Ser Uncertain significance Single submitter
- DSC1 p.Gly435Asp Uncertain significance Single submitter
- DSC1 p.Gly512Glu Uncertain significance Single submitter
- DSC1 p.Gly773Ala Uncertain significance Single submitter
- DSC1 p.Gly860Ser Uncertain significance Single submitter
- DSC1 p.His123Arg Uncertain significance Single submitter
- DSC1 p.His842Arg Uncertain significance Single submitter
- DSC1 p.Ile168Thr Uncertain significance Single submitter
- DSC1 p.Ile437Thr Uncertain significance Single submitter
- DSC1 p.Ile463Val Uncertain significance Single submitter
- DSC1 p.Ile583Thr Uncertain significance Single submitter
- DSC1 p.Ile621Val Uncertain significance Single submitter
- DSC1 p.Ile694Val Uncertain significance Single submitter
- DSC1 p.Ile892Phe Uncertain significance Single submitter
- DSC1 p.Leu52Pro Uncertain significance Single submitter
- DSC1 p.Leu530Arg Uncertain significance Single submitter
- DSC1 p.Leu631Phe Uncertain significance Single submitter
- DSC1 p.Lys14Asn Uncertain significance Single submitter
- DSC1 p.Lys32Glu Uncertain significance Single submitter
- DSC1 p.Lys717Arg Uncertain significance Single submitter
- DSC1 p.Lys721Arg Uncertain significance Single submitter
- DSC1 p.Lys893Asn Uncertain significance Single submitter
- DSC1 p.Met322Ile Uncertain significance Single submitter
- DSC1 p.Met675Ile Uncertain significance Single submitter
- DSC1 p.Met764Ile Uncertain significance Single submitter
- DSC1 p.Phe822Val Uncertain significance Single submitter
- DSC1 p.Phe876Cys Uncertain significance Single submitter
- DSC1 p.Pro181His Uncertain significance Single submitter
- DSC1 p.Pro308Ser Uncertain significance Single submitter
- DSC1 p.Pro409Leu Uncertain significance Single submitter
- DSC1 p.Pro606Arg Uncertain significance Single submitter
- DSC1 p.Pro725Ser Uncertain significance Single submitter
- DSC1 p.Ser10Asn Uncertain significance Single submitter
- DSC1 p.Ser406Asn Uncertain significance Single submitter
- DSC1 p.Ser406Thr Uncertain significance Single submitter
- DSC1 p.Ser757Ala Uncertain significance Single submitter
- DSC1 p.Thr124Ile Uncertain significance Single submitter
- DSC1 p.Thr197Lys Uncertain significance Single submitter
- DSC1 p.Thr277Ile Uncertain significance Single submitter
- DSC1 p.Thr385Ile Uncertain significance Single submitter
- DSC1 p.Thr385Ser Uncertain significance Single submitter
- DSC1 p.Tyr424Asp Uncertain significance Single submitter
- DSC1 p.Tyr850Ser Uncertain significance Single submitter
- DSC1 p.Val155Ile Uncertain significance Single submitter
- DSC1 p.Val177Met Uncertain significance Single submitter
- DSC1 p.Val251Ala Uncertain significance Single submitter
- DSC1 p.Val565Ala Uncertain significance Single submitter
- DSC1 p.Val803Ile Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- DSC1 p.Ile200Thr Benign Multiple submitters
- DSC1 p.Ala859Thr Uncertain significance Single submitter
- DSC1 p.Arg102Trp Uncertain significance Single submitter
- DSC1 p.Arg131His Uncertain significance Single submitter
- DSC1 p.Arg278His Uncertain significance Single submitter
- DSC1 p.Arg374Gln Uncertain significance Single submitter
- DSC1 p.Arg428His Uncertain significance Single submitter
- DSC1 p.Arg634Gln Uncertain significance Single submitter
- DSC1 p.Arg634Trp Uncertain significance Single submitter
- DSC1 p.Arg63Trp Uncertain significance Single submitter
- DSC1 p.Asn516Thr Uncertain significance Single submitter
- DSC1 p.Asn851Ile Uncertain significance Single submitter
- DSC1 p.Asp612Asn Uncertain significance Single submitter
- DSC1 p.Asp625Tyr Uncertain significance Single submitter
- DSC1 p.Asp727Gly Uncertain significance Single submitter
- DSC1 p.Cys864Tyr Uncertain significance Single submitter
- DSC1 p.Gln330Pro Uncertain significance Single submitter
- DSC1 p.Glu871Gln Uncertain significance Single submitter
- DSC1 p.Gly483Asp Uncertain significance Single submitter
- DSC1 p.Gly805Arg Uncertain significance Single submitter
- DSC1 p.Gly873Arg Uncertain significance Single submitter
- DSC1 p.Ile187Thr Uncertain significance Single submitter
- DSC1 p.Ile187Val Uncertain significance Single submitter
- DSC1 p.Ile283Leu Uncertain significance Single submitter
- DSC1 p.Ile77Val Uncertain significance Single submitter
- DSC1 p.Phe249Leu Uncertain significance Single submitter
- DSC1 p.Phe822Cys Uncertain significance Single submitter
- DSC1 p.Pro485Gln Uncertain significance Single submitter
- DSC1 p.Ser132Gly Uncertain significance Single submitter
- DSC1 p.Ser257Cys Uncertain significance Single submitter
- DSC1 p.Ser443Pro Uncertain significance Single submitter
- DSC1 p.Ser502Gly Uncertain significance Single submitter
- DSC1 p.Ser60Ile Uncertain significance Single submitter
- DSC1 p.Ser65Gly Uncertain significance Single submitter
- DSC1 p.Ser679Cys Uncertain significance Single submitter
- DSC1 p.Thr341Ser Uncertain significance Single submitter
- DSC1 p.Thr45Pro Uncertain significance Single submitter
- DSC1 p.Thr628Ile Uncertain significance Single submitter
- DSC1 p.Thr799Asn Uncertain significance Single submitter
- DSC1 p.Thr799Ile Uncertain significance Single submitter
- DSC1 p.Tyr642Phe Uncertain significance Single submitter
- DSC1 p.Val109Ala Uncertain significance Single submitter
- DSC1 p.Val477Leu Uncertain significance Single submitter
- DSC1 p.Val47Ala Uncertain significance Single submitter
- DSC1 p.Val847Asp Uncertain significance Single submitter
All DSC1 variants
Benign 4
- p.Ile200Thr Multiple submitters ⚠
- p.Met659Arg Multiple submitters
- p.Thr710= Multiple submitters
- c.1520+9C>G Single submitter
Likely benign 1
- p.Val109Ile Single submitter
Uncertain significance 118
- p.Ala128Pro Single submitter ⚠
- p.Ala209Val Single submitter ⚠
- p.Ala221Glu Single submitter ⚠
- p.Ala239Thr Single submitter ⚠
- p.Ala574Thr Single submitter ⚠
- p.Ala693Val Single submitter ⚠
- p.Ala6Pro Single submitter ⚠
- p.Ala859Thr Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg374Gln Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Arg634Gln Single submitter ⚠
- p.Arg634Leu Single submitter ⚠
- p.Arg634Trp Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Arg63Trp Single submitter ⚠
- p.Arg663Thr Single submitter ⚠
- p.Arg826Gln Single submitter ⚠
- p.Arg868Leu Single submitter ⚠
- p.Asn516Thr Single submitter ⚠
- p.Asn586Ser Single submitter ⚠
- p.Asn686Thr Single submitter ⚠
- p.Asn851Asp Single submitter ⚠
- p.Asn851Ile Single submitter ⚠
- p.Asp193Asn Single submitter ⚠
- p.Asp369Asn Single submitter ⚠
- p.Asp526His Single submitter ⚠
- p.Asp612Asn Single submitter ⚠
- p.Asp625Tyr Single submitter ⚠
- p.Asp727Gly Single submitter ⚠
- p.Asp837Glu Single submitter ⚠
- p.Cys667Gly Single submitter ⚠
- p.Cys864Tyr Single submitter ⚠
- p.Cys891Ser Single submitter ⚠
- p.Gln157Arg Single submitter ⚠
- p.Gln285Lys Single submitter ⚠
- p.Gln330Pro Single submitter ⚠
- p.Glu206Lys Single submitter ⚠
- p.Glu829Lys Single submitter ⚠
- p.Glu871Gln Single submitter ⚠
- p.Gly149Cys Single submitter ⚠
- p.Gly333Ser Single submitter ⚠
- p.Gly435Asp Single submitter ⚠
- p.Gly483Asp Single submitter ⚠
- p.Gly512Glu Single submitter ⚠
- p.Gly773Ala Single submitter ⚠
- p.Gly805Arg Single submitter ⚠
- p.Gly860Ser Single submitter ⚠
- p.Gly873Arg Single submitter ⚠
- p.His123Arg Single submitter ⚠
- p.His842Arg Single submitter ⚠
- p.Ile168Thr Single submitter ⚠
- p.Ile187Thr Single submitter ⚠
- p.Ile187Val Single submitter ⚠
- p.Ile283Leu Single submitter ⚠
- p.Ile437Thr Single submitter ⚠
- p.Ile463Val Single submitter ⚠
- p.Ile583Thr Single submitter ⚠
- p.Ile621Val Single submitter ⚠
- p.Ile694Val Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Ile892Phe Single submitter ⚠
- p.Leu52Pro Single submitter ⚠
- p.Leu530Arg Single submitter ⚠
- p.Leu631Phe Single submitter ⚠
- p.Lys14Asn Single submitter ⚠
- p.Lys32Glu Single submitter ⚠
- p.Lys717Arg Single submitter ⚠
- p.Lys721Arg Single submitter ⚠
- p.Lys893Asn Single submitter ⚠
- p.Met322Ile Single submitter ⚠
- p.Met675Ile Single submitter ⚠
- p.Met764Ile Single submitter ⚠
- p.Phe249Leu Single submitter ⚠
- p.Phe822Cys Single submitter ⚠
- p.Phe822Val Single submitter ⚠
- p.Phe876Cys Single submitter ⚠
- p.Pro181His Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Pro409Leu Single submitter ⚠
- p.Pro485Gln Single submitter ⚠
- p.Pro606Arg Single submitter ⚠
- p.Pro725Ser Single submitter ⚠
- p.Ser10Asn Single submitter ⚠
- p.Ser132Gly Single submitter ⚠
- p.Ser257Cys Single submitter ⚠
- p.Ser406Asn Single submitter ⚠
- p.Ser406Thr Single submitter ⚠
- p.Ser443Pro Single submitter ⚠
- p.Ser502Gly Single submitter ⚠
- p.Ser60Ile Single submitter ⚠
- p.Ser65Gly Single submitter ⚠
- p.Ser679Cys Single submitter ⚠
- p.Ser757Ala Single submitter ⚠
- p.Thr124Ile Single submitter ⚠
- p.Thr197Lys Single submitter ⚠
- p.Thr277Ile Single submitter ⚠
- p.Thr341Ser Single submitter ⚠
- p.Thr385Ile Single submitter ⚠
- p.Thr385Ser Single submitter ⚠
- p.Thr45Pro Single submitter ⚠
- p.Thr628Ile Single submitter ⚠
- p.Thr799Asn Single submitter ⚠
- p.Thr799Ile Single submitter ⚠
- p.Tyr424Asp Single submitter ⚠
- p.Tyr642Phe Single submitter ⚠
- p.Tyr850Ser Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val155Ile Single submitter ⚠
- p.Val177Met Single submitter ⚠
- p.Val251Ala Single submitter ⚠
- p.Val477Leu Single submitter ⚠
- p.Val47Ala Single submitter ⚠
- p.Val565Ala Single submitter ⚠
- p.Val803Ile Single submitter ⚠
- p.Val847Asp Single submitter ⚠