Sugi Variant

Sugi Variant/DSG4

DSG4 — 335 ClinVar variants

All ClinVar germline DSG4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 196 flagged for review →

12 Pathogenic · 7 Likely pathogenic · 33 Conflicting · 32 Benign · 13 Benign/Likely benign · 40 Likely benign · 198 Uncertain significance

Full DSG4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 196

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 15

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 113

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 68

The independent predictors disagree with each other — read with care.

All DSG4 variants

Pathogenic 12

Likely pathogenic 7

Conflicting classifications of pathogenicity 33

Benign 32

Benign/Likely benign 13

Likely benign 40

Uncertain significance 198