DTD1 — 24 ClinVar variants
All ClinVar germline DTD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
24 Uncertain significance
Full DTD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTD1 p.Ala195Gly Uncertain significance Single submitter
- DTD1 p.Ala195Val Uncertain significance Single submitter
- DTD1 p.Arg189Gln Uncertain significance Single submitter
- DTD1 p.Arg53Pro Uncertain significance Single submitter
- DTD1 p.Asn107Ser Uncertain significance Single submitter
- DTD1 p.Gln71His Uncertain significance Single submitter
- DTD1 p.Gly104Cys Uncertain significance Single submitter
- DTD1 p.Ile135Val Uncertain significance Single submitter
- DTD1 p.Leu145Arg Uncertain significance Single submitter
- DTD1 p.Leu160Val Uncertain significance Single submitter
- DTD1 p.Phe105Ser Uncertain significance Single submitter
- DTD1 p.Phe105Val Uncertain significance Single submitter
- DTD1 p.Phe93Cys Uncertain significance Single submitter
- DTD1 p.Tyr72Cys Uncertain significance Single submitter
- DTD1 p.Val133Leu Uncertain significance Single submitter
- DTD1 p.Val133Met Uncertain significance Single submitter
- DTD1 p.Val46Ala Uncertain significance Single submitter
- DTD1 p.Val54Leu Uncertain significance Single submitter
- DTD1 p.Val77Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All DTD1 variants
Uncertain significance 24
- p.Ala195Gly Single submitter ⚠
- p.Ala195Val Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg53Pro Single submitter ⚠
- p.Asn107Ser Single submitter ⚠
- p.Gln71His Single submitter ⚠
- p.Gly104Cys Single submitter ⚠
- p.Gly60Arg Single submitter
- p.Ile135Val Single submitter ⚠
- p.Leu145Arg Single submitter ⚠
- p.Leu160Val Single submitter ⚠
- p.Leu30Phe Single submitter ⚠
- p.Phe105Ser Single submitter ⚠
- p.Phe105Val Single submitter ⚠
- p.Phe93Cys Single submitter ⚠
- p.Thr38Met Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Tyr72Cys Single submitter ⚠
- p.Val133Leu Single submitter ⚠
- p.Val133Met Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val46Ala Single submitter ⚠
- p.Val54Leu Single submitter ⚠
- p.Val77Ile Single submitter ⚠