DTD2 — 17 ClinVar variants
All ClinVar germline DTD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
3 Likely benign · 14 Uncertain significance
Full DTD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- DTD2 p.Ala12Glu Uncertain significance Single submitter
- DTD2 p.Arg102Gly Uncertain significance Single submitter
- DTD2 p.Asn86Lys Uncertain significance Single submitter
- DTD2 p.Gln121Pro Uncertain significance Single submitter
- DTD2 p.Glu113Gly Uncertain significance Single submitter
- DTD2 p.Ile166Thr Uncertain significance Single submitter
- DTD2 p.Ile87Val Likely benign Single submitter
- DTD2 p.Leu118Val Uncertain significance Single submitter
- DTD2 p.Leu13Phe Uncertain significance Single submitter
- DTD2 p.Phe49Leu Uncertain significance Single submitter
All DTD2 variants
Likely benign 3
- p.Ile7Met Single submitter
- p.Ile87Val Single submitter ⚠
- p.Phe116Leu Single submitter
Uncertain significance 14
- p.Ala12Glu Single submitter ⚠
- p.Arg102Gly Single submitter ⚠
- p.Asn86Lys Single submitter ⚠
- p.Gln121Pro Single submitter ⚠
- p.Glu113Gly Single submitter ⚠
- p.Gly149Arg Single submitter ⚠
- p.Ile166Thr Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Met104Arg Single submitter ⚠
- p.Met60Thr Single submitter ⚠
- p.Phe168Ile Single submitter ⚠
- p.Phe49Leu Single submitter ⚠
- p.Tyr148Cys Single submitter ⚠