DTL — 69 ClinVar variants
All ClinVar germline DTL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
1 Benign · 5 Likely benign · 63 Uncertain significance
Full DTL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTL p.Ala210Val Uncertain significance Single submitter
- DTL p.Ala474Gly Uncertain significance Single submitter
- DTL p.Arg482Lys Uncertain significance Single submitter
- DTL p.Arg670Trp Uncertain significance Single submitter
- DTL p.Arg678Gln Uncertain significance Single submitter
- DTL p.Asn442Ser Uncertain significance Single submitter
- DTL p.Asn4Ser Uncertain significance Single submitter
- DTL p.Asn583Asp Uncertain significance Single submitter
- DTL p.Asn594Ser Uncertain significance Single submitter
- DTL p.Cys438Phe Uncertain significance Single submitter
- DTL p.Cys438Tyr Uncertain significance Single submitter
- DTL p.Cys643Phe Uncertain significance Single submitter
- DTL p.Gly177Val Uncertain significance Single submitter
- DTL p.Gly399Ala Uncertain significance Single submitter
- DTL p.Ile343Val Uncertain significance Single submitter
- DTL p.Ile469Met Uncertain significance Single submitter
- DTL p.Ile480Val Uncertain significance Single submitter
- DTL p.Leu263Pro Uncertain significance Single submitter
- DTL p.Lys202Asn Uncertain significance Single submitter
- DTL p.Lys402Glu Uncertain significance Single submitter
- DTL p.Lys669Ile Uncertain significance Single submitter
- DTL p.Met499Ile Uncertain significance Single submitter
- DTL p.Phe298Tyr Uncertain significance Single submitter
- DTL p.Pro398Arg Uncertain significance Single submitter
- DTL p.Pro445Leu Uncertain significance Single submitter
- DTL p.Pro465Ser Uncertain significance Single submitter
- DTL p.Pro518Ser Uncertain significance Single submitter
- DTL p.Pro621Leu Uncertain significance Single submitter
- DTL p.Pro622Leu Uncertain significance Single submitter
- DTL p.Pro685Ser Uncertain significance Single submitter
- DTL p.Pro698Arg Uncertain significance Single submitter
- DTL p.Pro698Leu Uncertain significance Single submitter
- DTL p.Ser337Arg Uncertain significance Single submitter
- DTL p.Ser487Pro Uncertain significance Single submitter
- DTL p.Ser547Ala Uncertain significance Single submitter
- DTL p.Ser59Thr Uncertain significance Single submitter
- DTL p.Thr158Met Uncertain significance Single submitter
- DTL p.Thr301Ile Uncertain significance Single submitter
- DTL p.Thr364Met Uncertain significance Single submitter
- DTL p.Thr522Ile Uncertain significance Single submitter
- DTL p.Trp368Arg Uncertain significance Single submitter
- DTL p.Val101Ile Uncertain significance Single submitter
- DTL p.Val155Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- DTL p.Arg389Ser Uncertain significance Single submitter
- DTL p.Arg502Gly Uncertain significance Single submitter
- DTL p.Arg670Gln Uncertain significance Single submitter
- DTL p.Asn228Ile Uncertain significance Single submitter
- DTL p.Glu227Lys Uncertain significance Single submitter
- DTL p.Gly283Asp Uncertain significance Single submitter
- DTL p.His65Gln Uncertain significance Single submitter
- DTL p.Leu303Trp Uncertain significance Single submitter
- DTL p.Pro307Ser Uncertain significance Single submitter
- DTL p.Ser35Thr Uncertain significance Single submitter
- DTL p.Ser425Arg Uncertain significance Single submitter
- DTL p.Ser468Phe Uncertain significance Single submitter
- DTL p.Ser520Leu Uncertain significance Single submitter
- DTL p.Ser539Phe Uncertain significance Single submitter
- DTL p.Ser682Phe Uncertain significance Single submitter
- DTL p.Thr196Ile Uncertain significance Single submitter
- DTL p.Thr354Ala Uncertain significance Single submitter
- DTL p.Thr46Ile Uncertain significance Single submitter
- DTL p.Thr506Pro Uncertain significance Single submitter
- DTL p.Trp662Cys Uncertain significance Single submitter
All DTL variants
Benign 1
- p.Arg715= Multiple submitters
Likely benign 5
- p.Gln26= Single submitter
- p.Leu29= Single submitter
- p.Phe721Tyr Single submitter
- p.Phe91Val Single submitter
- p.Thr405= Single submitter
Uncertain significance 63
- p.Ala210Val Single submitter ⚠
- p.Ala474Gly Single submitter ⚠
- p.Arg389Ser Single submitter ⚠
- p.Arg482Lys Single submitter ⚠
- p.Arg502Gly Single submitter ⚠
- p.Arg670Gln Single submitter ⚠
- p.Arg670Trp Single submitter ⚠
- p.Arg678Gln Single submitter ⚠
- p.Asn228Ile Single submitter ⚠
- p.Asn442Ser Single submitter ⚠
- p.Asn4Ser Single submitter ⚠
- p.Asn583Asp Single submitter ⚠
- p.Asn594Ser Single submitter ⚠
- p.Cys438Phe Single submitter ⚠
- p.Cys438Tyr Single submitter ⚠
- p.Cys643Phe Single submitter ⚠
- p.Glu227Lys Single submitter ⚠
- p.Gly177Val Single submitter ⚠
- p.Gly283Asp Single submitter ⚠
- p.Gly399Ala Single submitter ⚠
- p.His65Gln Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Ile469Met Single submitter ⚠
- p.Ile480Val Single submitter ⚠
- p.Leu263Pro Single submitter ⚠
- p.Leu303Trp Single submitter ⚠
- p.Lys202Asn Single submitter ⚠
- p.Lys402Glu Single submitter ⚠
- p.Lys669Ile Single submitter ⚠
- p.Met499Ile Single submitter ⚠
- p.Phe298Tyr Single submitter ⚠
- p.Pro307Ser Single submitter ⚠
- p.Pro398Arg Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro465Ser Single submitter ⚠
- p.Pro518Ser Single submitter ⚠
- p.Pro621Leu Single submitter ⚠
- p.Pro622Leu Single submitter ⚠
- p.Pro685Ser Single submitter ⚠
- p.Pro698Arg Single submitter ⚠
- p.Pro698Leu Single submitter ⚠
- p.Ser337Arg Single submitter ⚠
- p.Ser35Thr Single submitter ⚠
- p.Ser425Arg Single submitter ⚠
- p.Ser468Phe Single submitter ⚠
- p.Ser487Pro Single submitter ⚠
- p.Ser520Leu Single submitter ⚠
- p.Ser539Phe Single submitter ⚠
- p.Ser547Ala Single submitter ⚠
- p.Ser59Thr Single submitter ⚠
- p.Ser682Phe Single submitter ⚠
- p.Thr158Met Single submitter ⚠
- p.Thr196Ile Single submitter ⚠
- p.Thr301Ile Single submitter ⚠
- p.Thr354Ala Single submitter ⚠
- p.Thr364Met Single submitter ⚠
- p.Thr46Ile Single submitter ⚠
- p.Thr506Pro Single submitter ⚠
- p.Thr522Ile Single submitter ⚠
- p.Trp368Arg Single submitter ⚠
- p.Trp662Cys Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val155Ile Single submitter ⚠