DTNB — 92 ClinVar variants
All ClinVar germline DTNB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
1 Benign · 4 Likely benign · 87 Uncertain significance
Full DTNB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTNB p.Ala134Thr Uncertain significance Single submitter
- DTNB p.Ala575Val Uncertain significance Single submitter
- DTNB p.Ala577Thr Uncertain significance Single submitter
- DTNB p.Ala613Ser Uncertain significance Single submitter
- DTNB p.Arg124Gln Uncertain significance Single submitter
- DTNB p.Arg255Trp Uncertain significance Single submitter
- DTNB p.Arg407Cys Uncertain significance Single submitter
- DTNB p.Arg421His Uncertain significance Single submitter
- DTNB p.Arg549His Uncertain significance Single submitter
- DTNB p.Arg9Gln Uncertain significance Single submitter
- DTNB p.Asn159Ser Uncertain significance Single submitter
- DTNB p.Asp431Gly Uncertain significance Single submitter
- DTNB p.Gln362Arg Uncertain significance Single submitter
- DTNB p.Glu4Val Uncertain significance Single submitter
- DTNB p.Gly277Val Uncertain significance Single submitter
- DTNB p.Gly539Ala Uncertain significance Single submitter
- DTNB p.Gly554Ser Uncertain significance Single submitter
- DTNB p.Gly567Arg Uncertain significance Single submitter
- DTNB p.Gly567Glu Uncertain significance Single submitter
- DTNB p.Gly627Asp Uncertain significance Single submitter
- DTNB p.Ile20Met Uncertain significance Single submitter
- DTNB p.Ile367Met Uncertain significance Single submitter
- DTNB p.Leu111Phe Uncertain significance Single submitter
- DTNB p.Leu398Met Uncertain significance Single submitter
- DTNB p.Leu41Ser Uncertain significance Single submitter
- DTNB p.Lys518Met Uncertain significance Single submitter
- DTNB p.Met144Leu Uncertain significance Single submitter
- DTNB p.Pro355Leu Uncertain significance Single submitter
- DTNB p.Pro532Leu Uncertain significance Single submitter
- DTNB p.Ser550Ala Uncertain significance Single submitter
- DTNB p.Ser566Asn Uncertain significance Single submitter
- DTNB p.Ser5Thr Uncertain significance Single submitter
- DTNB p.Thr11Ile Uncertain significance Single submitter
- DTNB p.Thr580Met Uncertain significance Single submitter
- DTNB p.Tyr150Cys Uncertain significance Single submitter
- DTNB p.Val572Leu Uncertain significance Single submitter
Predictors split 51
The independent predictors disagree with each other — read with care.
- DTNB p.Ala376Val Uncertain significance Single submitter
- DTNB p.Ala410Ser Uncertain significance Single submitter
- DTNB p.Ala526Thr Uncertain significance Single submitter
- DTNB p.Ala61Gly Uncertain significance Single submitter
- DTNB p.Arg257Gln Uncertain significance Single submitter
- DTNB p.Arg384Ser Uncertain significance Single submitter
- DTNB p.Arg390Cys Uncertain significance Single submitter
- DTNB p.Arg397Gln Uncertain significance Single submitter
- DTNB p.Arg403Cys Uncertain significance Single submitter
- DTNB p.Arg456Cys Uncertain significance Single submitter
- DTNB p.Arg458Cys Uncertain significance Single submitter
- DTNB p.Arg542Trp Uncertain significance Single submitter
- DTNB p.Arg80Cys Uncertain significance Single submitter
- DTNB p.Arg9Trp Uncertain significance Single submitter
- DTNB p.Asn159Asp Uncertain significance Single submitter
- DTNB p.Asn583Lys Uncertain significance Single submitter
- DTNB p.Asn586His Uncertain significance Single submitter
- DTNB p.Asp373Asn Uncertain significance Single submitter
- DTNB p.Gln200Arg Uncertain significance Single submitter
- DTNB p.Gln323Glu Uncertain significance Single submitter
- DTNB p.Gln362Lys Uncertain significance Single submitter
- DTNB p.Gln455Lys Uncertain significance Single submitter
- DTNB p.Glu105Gly Uncertain significance Single submitter
- DTNB p.Glu444Gln Uncertain significance Single submitter
- DTNB p.Glu611Lys Uncertain significance Single submitter
- DTNB p.Glu617Gln Uncertain significance Single submitter
- DTNB p.Gly278Ser Uncertain significance Single submitter
- DTNB p.Gly569Trp Uncertain significance Single submitter
- DTNB p.Gly612Cys Uncertain significance Single submitter
- DTNB p.His317Arg Uncertain significance Single submitter
- DTNB p.His370Tyr Uncertain significance Single submitter
- DTNB p.His375Arg Uncertain significance Single submitter
- DTNB p.His461Gln Uncertain significance Single submitter
- DTNB p.His51Tyr Uncertain significance Single submitter
- DTNB p.Ile333Thr Uncertain significance Single submitter
- DTNB p.Leu112Val Uncertain significance Single submitter
- DTNB p.Met135Thr Uncertain significance Single submitter
- DTNB p.Met251Ile Uncertain significance Single submitter
- DTNB p.Met252Arg Uncertain significance Single submitter
- DTNB p.Pro178Ala Uncertain significance Single submitter
- DTNB p.Pro217Ala Uncertain significance Single submitter
- DTNB p.Pro315Arg Uncertain significance Single submitter
- DTNB p.Pro336His Uncertain significance Single submitter
- DTNB p.Ser193Leu Uncertain significance Single submitter
- DTNB p.Ser281Gly Uncertain significance Single submitter
- DTNB p.Ser594Thr Uncertain significance Single submitter
- DTNB p.Thr128Met Uncertain significance Single submitter
- DTNB p.Thr179Ala Uncertain significance Single submitter
- DTNB p.Thr99Ala Uncertain significance Single submitter
- DTNB p.Tyr90Cys Uncertain significance Single submitter
- DTNB p.Val241Met Uncertain significance Single submitter
All DTNB variants
Benign 1
- p.Val568= Multiple submitters
Likely benign 4
- p.Asn429= Single submitter
- p.Gly277Ser Single submitter
- p.Thr73Ala Single submitter
- p.Val419Met Single submitter
Uncertain significance 87
- p.Ala134Thr Single submitter ⚠
- p.Ala376Val Single submitter ⚠
- p.Ala410Ser Single submitter ⚠
- p.Ala526Thr Single submitter ⚠
- p.Ala575Val Single submitter ⚠
- p.Ala577Thr Single submitter ⚠
- p.Ala613Ser Single submitter ⚠
- p.Ala61Gly Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg384Ser Single submitter ⚠
- p.Arg390Cys Single submitter ⚠
- p.Arg397Gln Single submitter ⚠
- p.Arg403Cys Single submitter ⚠
- p.Arg407Cys Single submitter ⚠
- p.Arg421His Single submitter ⚠
- p.Arg456Cys Single submitter ⚠
- p.Arg458Cys Single submitter ⚠
- p.Arg542Trp Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg9Gln Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asn159Asp Single submitter ⚠
- p.Asn159Ser Single submitter ⚠
- p.Asn583Lys Single submitter ⚠
- p.Asn586His Single submitter ⚠
- p.Asp373Asn Single submitter ⚠
- p.Asp431Gly Single submitter ⚠
- p.Gln200Arg Single submitter ⚠
- p.Gln323Glu Single submitter ⚠
- p.Gln362Arg Single submitter ⚠
- p.Gln362Lys Single submitter ⚠
- p.Gln455Lys Single submitter ⚠
- p.Glu105Gly Single submitter ⚠
- p.Glu444Gln Single submitter ⚠
- p.Glu4Val Single submitter ⚠
- p.Glu611Lys Single submitter ⚠
- p.Glu617Gln Single submitter ⚠
- p.Gly277Val Single submitter ⚠
- p.Gly278Ser Single submitter ⚠
- p.Gly539Ala Single submitter ⚠
- p.Gly554Ser Single submitter ⚠
- p.Gly567Arg Single submitter ⚠
- p.Gly567Glu Single submitter ⚠
- p.Gly569Trp Single submitter ⚠
- p.Gly612Cys Single submitter ⚠
- p.Gly627Asp Single submitter ⚠
- p.His317Arg Single submitter ⚠
- p.His370Tyr Single submitter ⚠
- p.His375Arg Single submitter ⚠
- p.His461Gln Single submitter ⚠
- p.His51Tyr Single submitter ⚠
- p.Ile20Met Single submitter ⚠
- p.Ile333Thr Single submitter ⚠
- p.Ile367Met Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu112Val Single submitter ⚠
- p.Leu398Met Single submitter ⚠
- p.Leu41Ser Single submitter ⚠
- p.Lys518Met Single submitter ⚠
- p.Met135Thr Single submitter ⚠
- p.Met144Leu Single submitter ⚠
- p.Met251Ile Single submitter ⚠
- p.Met252Arg Single submitter ⚠
- p.Pro178Ala Single submitter ⚠
- p.Pro217Ala Single submitter ⚠
- p.Pro315Arg Single submitter ⚠
- p.Pro336His Single submitter ⚠
- p.Pro355Leu Single submitter ⚠
- p.Pro532Leu Single submitter ⚠
- p.Ser193Leu Single submitter ⚠
- p.Ser281Gly Single submitter ⚠
- p.Ser550Ala Single submitter ⚠
- p.Ser566Asn Single submitter ⚠
- p.Ser594Thr Single submitter ⚠
- p.Ser5Thr Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr128Met Single submitter ⚠
- p.Thr179Ala Single submitter ⚠
- p.Thr580Met Single submitter ⚠
- p.Thr99Ala Single submitter ⚠
- p.Tyr150Cys Single submitter ⚠
- p.Tyr90Cys Single submitter ⚠
- p.Val241Met Single submitter ⚠
- p.Val572Leu Single submitter ⚠