DTWD1 — 38 ClinVar variants
All ClinVar germline DTWD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Likely benign · 37 Uncertain significance
Full DTWD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTWD1 p.Ala31Ser Uncertain significance Single submitter
- DTWD1 p.Arg238His Uncertain significance Single submitter
- DTWD1 p.Asn210Ser Uncertain significance Single submitter
- DTWD1 p.Asp275Asn Uncertain significance Single submitter
- DTWD1 p.Cys194Phe Uncertain significance Single submitter
- DTWD1 p.Cys40Arg Uncertain significance Single submitter
- DTWD1 p.Cys40Tyr Uncertain significance Single submitter
- DTWD1 p.Cys61Tyr Uncertain significance Single submitter
- DTWD1 p.Gln52Arg Uncertain significance Single submitter
- DTWD1 p.Gly104Asp Uncertain significance Single submitter
- DTWD1 p.Gly166Ser Uncertain significance Single submitter
- DTWD1 p.Gly196Val Uncertain significance Single submitter
- DTWD1 p.Gly62Ser Uncertain significance Single submitter
- DTWD1 p.His110Tyr Uncertain significance Single submitter
- DTWD1 p.Leu225Ile Uncertain significance Single submitter
- DTWD1 p.Pro171Thr Uncertain significance Single submitter
- DTWD1 p.Pro85Leu Uncertain significance Single submitter
- DTWD1 p.Ser12Asn Uncertain significance Single submitter
- DTWD1 p.Ser16Thr Uncertain significance Single submitter
- DTWD1 p.Thr107Ala Uncertain significance Single submitter
- DTWD1 p.Thr234Ile Uncertain significance Single submitter
- DTWD1 p.Thr263Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DTWD1 p.Arg178Cys Uncertain significance Single submitter
- DTWD1 p.Arg178His Uncertain significance Single submitter
- DTWD1 p.Asn78His Uncertain significance Single submitter
- DTWD1 p.Asp188Val Uncertain significance Single submitter
- DTWD1 p.Gly62Val Uncertain significance Single submitter
- DTWD1 p.Ile127Val Uncertain significance Single submitter
- DTWD1 p.Ile147Leu Uncertain significance Single submitter
- DTWD1 p.Ile205Val Uncertain significance Single submitter
- DTWD1 p.Ile96Val Uncertain significance Single submitter
- DTWD1 p.Leu36Pro Uncertain significance Single submitter
- DTWD1 p.Lys297Asn Uncertain significance Single submitter
- DTWD1 p.Phe257Cys Uncertain significance Single submitter
- DTWD1 p.Pro116Thr Uncertain significance Single submitter
- DTWD1 p.Pro144Ser Uncertain significance Single submitter
- DTWD1 p.Thr123Met Uncertain significance Single submitter
All DTWD1 variants
Likely benign 1
- p.Ile7Val Single submitter
Uncertain significance 37
- p.Ala31Ser Single submitter ⚠
- p.Arg178Cys Single submitter ⚠
- p.Arg178His Single submitter ⚠
- p.Arg238His Single submitter ⚠
- p.Asn210Ser Single submitter ⚠
- p.Asn78His Single submitter ⚠
- p.Asp188Val Single submitter ⚠
- p.Asp275Asn Single submitter ⚠
- p.Cys194Phe Single submitter ⚠
- p.Cys40Arg Single submitter ⚠
- p.Cys40Tyr Single submitter ⚠
- p.Cys61Tyr Single submitter ⚠
- p.Gln52Arg Single submitter ⚠
- p.Gly104Asp Single submitter ⚠
- p.Gly166Ser Single submitter ⚠
- p.Gly196Val Single submitter ⚠
- p.Gly62Ser Single submitter ⚠
- p.Gly62Val Single submitter ⚠
- p.His110Tyr Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Ile147Leu Single submitter ⚠
- p.Ile205Val Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Leu225Ile Single submitter ⚠
- p.Leu36Pro Single submitter ⚠
- p.Lys297Asn Single submitter ⚠
- p.Phe257Cys Single submitter ⚠
- p.Pro116Thr Single submitter ⚠
- p.Pro144Ser Single submitter ⚠
- p.Pro171Thr Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Ser12Asn Single submitter ⚠
- p.Ser16Thr Single submitter ⚠
- p.Thr107Ala Single submitter ⚠
- p.Thr123Met Single submitter ⚠
- p.Thr234Ile Single submitter ⚠
- p.Thr263Ile Single submitter ⚠