DTWD2 — 77 ClinVar variants
All ClinVar germline DTWD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
1 Likely benign · 76 Uncertain significance
Full DTWD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTWD2 p.Ala228Pro Uncertain significance Single submitter
- DTWD2 p.Ala250Asp Uncertain significance Single submitter
- DTWD2 p.Ala42Ser Uncertain significance Single submitter
- DTWD2 p.Ala7Ser Uncertain significance Single submitter
- DTWD2 p.Arg144Gln Uncertain significance Single submitter
- DTWD2 p.Arg16Gly Uncertain significance Single submitter
- DTWD2 p.Arg213Trp Uncertain significance Single submitter
- DTWD2 p.Arg263Cys Uncertain significance Single submitter
- DTWD2 p.Arg263Leu Uncertain significance Single submitter
- DTWD2 p.Arg32Leu Uncertain significance Single submitter
- DTWD2 p.Arg74Gln Uncertain significance Single submitter
- DTWD2 p.Asn218Asp Uncertain significance Single submitter
- DTWD2 p.Asn218Ser Uncertain significance Single submitter
- DTWD2 p.Asn294Lys Uncertain significance Single submitter
- DTWD2 p.Asp49Glu Uncertain significance Single submitter
- DTWD2 p.Asp50Glu Uncertain significance Single submitter
- DTWD2 p.Asp50Gly Uncertain significance Single submitter
- DTWD2 p.Asp53Gly Uncertain significance Single submitter
- DTWD2 p.Gln11Arg Uncertain significance Single submitter
- DTWD2 p.Gln183His Uncertain significance Single submitter
- DTWD2 p.Gln241Arg Uncertain significance Single submitter
- DTWD2 p.Glu68Gln Uncertain significance Single submitter
- DTWD2 p.Gly128Ser Uncertain significance Single submitter
- DTWD2 p.Gly147Cys Uncertain significance Single submitter
- DTWD2 p.Gly34Ser Uncertain significance Single submitter
- DTWD2 p.Gly35Val Uncertain significance Single submitter
- DTWD2 p.Gly44Ser Uncertain significance Single submitter
- DTWD2 p.His90Leu Uncertain significance Single submitter
- DTWD2 p.Ile174Val Uncertain significance Single submitter
- DTWD2 p.Ile177Thr Uncertain significance Single submitter
- DTWD2 p.Leu10Arg Uncertain significance Single submitter
- DTWD2 p.Leu256Arg Uncertain significance Single submitter
- DTWD2 p.Leu269Pro Uncertain significance Single submitter
- DTWD2 p.Leu291Trp Uncertain significance Single submitter
- DTWD2 p.Lys106Glu Uncertain significance Single submitter
- DTWD2 p.Lys126Arg Uncertain significance Single submitter
- DTWD2 p.Lys185Glu Uncertain significance Single submitter
- DTWD2 p.Lys5Glu Uncertain significance Single submitter
- DTWD2 p.Pro101Leu Uncertain significance Single submitter
- DTWD2 p.Pro216Arg Uncertain significance Single submitter
- DTWD2 p.Pro216Ser Uncertain significance Single submitter
- DTWD2 p.Pro62Leu Uncertain significance Single submitter
- DTWD2 p.Ser140Ala Uncertain significance Single submitter
- DTWD2 p.Ser222Thr Uncertain significance Single submitter
- DTWD2 p.Thr93Ile Uncertain significance Single submitter
- DTWD2 p.Val200Leu Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- DTWD2 p.Ala227Thr Uncertain significance Single submitter
- DTWD2 p.Ala230Thr Uncertain significance Single submitter
- DTWD2 p.Ala40Val Uncertain significance Single submitter
- DTWD2 p.Arg109Cys Uncertain significance Single submitter
- DTWD2 p.Arg109His Uncertain significance Single submitter
- DTWD2 p.Arg246Cys Uncertain significance Single submitter
- DTWD2 p.Arg246His Uncertain significance Single submitter
- DTWD2 p.Arg287Thr Uncertain significance Single submitter
- DTWD2 p.Arg31Trp Uncertain significance Single submitter
- DTWD2 p.Arg66Ser Uncertain significance Single submitter
- DTWD2 p.Asp49Asn Uncertain significance Single submitter
- DTWD2 p.Gln76Arg Uncertain significance Single submitter
- DTWD2 p.Glu12Lys Uncertain significance Single submitter
- DTWD2 p.Glu134Lys Uncertain significance Single submitter
- DTWD2 p.Gly154Ala Uncertain significance Single submitter
- DTWD2 p.Gly259Ser Uncertain significance Single submitter
- DTWD2 p.Ile175Val Uncertain significance Single submitter
- DTWD2 p.Leu114Val Uncertain significance Single submitter
- DTWD2 p.Leu269Phe Uncertain significance Single submitter
- DTWD2 p.Leu274Val Uncertain significance Single submitter
- DTWD2 p.Lys198Glu Uncertain significance Single submitter
- DTWD2 p.Pro278Arg Uncertain significance Single submitter
- DTWD2 p.Pro38Leu Uncertain significance Single submitter
- DTWD2 p.Pro67Leu Uncertain significance Single submitter
- DTWD2 p.Ser18Phe Uncertain significance Single submitter
- DTWD2 p.Thr243Ala Uncertain significance Single submitter
- DTWD2 p.Thr70Asn Uncertain significance Single submitter
- DTWD2 p.Val229Ile Uncertain significance Single submitter
- DTWD2 p.Val37Met Uncertain significance Single submitter
- DTWD2 p.Val60Gly Uncertain significance Single submitter
All DTWD2 variants
Likely benign 1
- p.Asp28Ala Single submitter
Uncertain significance 76
- p.Ala227Thr Single submitter ⚠
- p.Ala228Pro Single submitter ⚠
- p.Ala230Thr Single submitter ⚠
- p.Ala250Asp Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala42Ser Single submitter ⚠
- p.Ala7Ser Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg16Gly Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg263Leu Single submitter ⚠
- p.Arg287Thr Single submitter ⚠
- p.Arg31Trp Single submitter ⚠
- p.Arg32Leu Single submitter ⚠
- p.Arg66Ser Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn218Asp Single submitter ⚠
- p.Asn218Ser Single submitter ⚠
- p.Asn294Lys Single submitter ⚠
- p.Asp49Asn Single submitter ⚠
- p.Asp49Glu Single submitter ⚠
- p.Asp50Glu Single submitter ⚠
- p.Asp50Gly Single submitter ⚠
- p.Asp53Gly Single submitter ⚠
- p.Gln11Arg Single submitter ⚠
- p.Gln183His Single submitter ⚠
- p.Gln241Arg Single submitter ⚠
- p.Gln76Arg Single submitter ⚠
- p.Glu12Lys Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Glu68Gln Single submitter ⚠
- p.Gly128Ser Single submitter ⚠
- p.Gly147Cys Single submitter ⚠
- p.Gly154Ala Single submitter ⚠
- p.Gly259Ser Single submitter ⚠
- p.Gly34Ser Single submitter ⚠
- p.Gly35Val Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.His90Leu Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile175Val Single submitter ⚠
- p.Ile177Thr Single submitter ⚠
- p.Leu10Arg Single submitter ⚠
- p.Leu114Val Single submitter ⚠
- p.Leu256Arg Single submitter ⚠
- p.Leu269Phe Single submitter ⚠
- p.Leu269Pro Single submitter ⚠
- p.Leu274Val Single submitter ⚠
- p.Leu291Trp Single submitter ⚠
- p.Lys106Glu Single submitter ⚠
- p.Lys126Arg Single submitter ⚠
- p.Lys185Glu Single submitter ⚠
- p.Lys198Glu Single submitter ⚠
- p.Lys5Glu Single submitter ⚠
- p.Pro101Leu Single submitter ⚠
- p.Pro216Arg Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Pro278Arg Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro62Leu Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Ser140Ala Single submitter ⚠
- p.Ser18Phe Single submitter ⚠
- p.Ser222Thr Single submitter ⚠
- p.Thr243Ala Single submitter ⚠
- p.Thr70Asn Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Val200Leu Single submitter ⚠
- p.Val229Ile Single submitter ⚠
- p.Val37Met Single submitter ⚠
- p.Val60Gly Single submitter ⚠