DTX1 — 83 ClinVar variants
All ClinVar germline DTX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Benign · 5 Likely benign · 77 Uncertain significance
Full DTX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTX1 p.Gly445Asp Uncertain significance Multiple submitters
- DTX1 p.Ala226Glu Uncertain significance Single submitter
- DTX1 p.Ala226Thr Uncertain significance Single submitter
- DTX1 p.Ala256Ser Uncertain significance Single submitter
- DTX1 p.Ala267Pro Uncertain significance Single submitter
- DTX1 p.Ala275Val Uncertain significance Single submitter
- DTX1 p.Ala307Val Uncertain significance Single submitter
- DTX1 p.Ala529Thr Uncertain significance Single submitter
- DTX1 p.Arg167Cys Uncertain significance Single submitter
- DTX1 p.Arg83His Uncertain significance Single submitter
- DTX1 p.Asn578Lys Uncertain significance Single submitter
- DTX1 p.Asp367Glu Uncertain significance Single submitter
- DTX1 p.Cys378Ser Uncertain significance Single submitter
- DTX1 p.Gln68Arg Uncertain significance Single submitter
- DTX1 p.Glu425Gln Uncertain significance Single submitter
- DTX1 p.Glu436Asp Uncertain significance Single submitter
- DTX1 p.Glu615Asp Uncertain significance Single submitter
- DTX1 p.Gly115Cys Uncertain significance Single submitter
- DTX1 p.Gly432Val Uncertain significance Single submitter
- DTX1 p.Gly498Ser Uncertain significance Single submitter
- DTX1 p.Gly524Arg Uncertain significance Single submitter
- DTX1 p.Gly570Asp Uncertain significance Single submitter
- DTX1 p.Gly594Ser Uncertain significance Single submitter
- DTX1 p.His520Tyr Uncertain significance Single submitter
- DTX1 p.Ile311Phe Uncertain significance Single submitter
- DTX1 p.Ile311Val Uncertain significance Single submitter
- DTX1 p.Ile511Phe Uncertain significance Single submitter
- DTX1 p.Phe527Leu Uncertain significance Single submitter
- DTX1 p.Pro271Ala Uncertain significance Single submitter
- DTX1 p.Pro347Thr Uncertain significance Single submitter
- DTX1 p.Pro39Ser Uncertain significance Single submitter
- DTX1 p.Pro483Leu Uncertain significance Single submitter
- DTX1 p.Thr288Pro Uncertain significance Single submitter
- DTX1 p.Thr303Ser Uncertain significance Single submitter
- DTX1 p.Thr591Met Uncertain significance Single submitter
- DTX1 p.Tyr424Phe Uncertain significance Single submitter
- DTX1 p.Tyr595His Uncertain significance Single submitter
- DTX1 p.Val22Leu Uncertain significance Single submitter
- DTX1 p.Val368Leu Uncertain significance Single submitter
- DTX1 p.Val438Met Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- DTX1 p.Ala260Val Uncertain significance Single submitter
- DTX1 p.Ala263Val Likely benign Single submitter
- DTX1 p.Ala42Val Uncertain significance Single submitter
- DTX1 p.Arg296Pro Uncertain significance Single submitter
- DTX1 p.Arg301His Uncertain significance Single submitter
- DTX1 p.Arg549Leu Uncertain significance Single submitter
- DTX1 p.Asn154Tyr Uncertain significance Single submitter
- DTX1 p.Asn405Ile Uncertain significance Single submitter
- DTX1 p.Asn459Ser Uncertain significance Single submitter
- DTX1 p.Asp510Asn Uncertain significance Single submitter
- DTX1 p.Asp510Gly Uncertain significance Single submitter
- DTX1 p.Glu477Lys Uncertain significance Single submitter
- DTX1 p.Gly285Glu Uncertain significance Single submitter
- DTX1 p.Gly426Asp Uncertain significance Single submitter
- DTX1 p.Gly58Ser Uncertain significance Single submitter
- DTX1 p.His34Pro Uncertain significance Single submitter
- DTX1 p.His494Asp Uncertain significance Single submitter
- DTX1 p.Ile357Phe Uncertain significance Single submitter
- DTX1 p.Ile74Val Uncertain significance Single submitter
- DTX1 p.Lys383Glu Uncertain significance Single submitter
- DTX1 p.Pro231Leu Uncertain significance Single submitter
- DTX1 p.Pro237Ser Uncertain significance Single submitter
- DTX1 p.Pro238Arg Uncertain significance Single submitter
- DTX1 p.Pro297Arg Uncertain significance Single submitter
- DTX1 p.Pro299His Uncertain significance Single submitter
- DTX1 p.Pro361Thr Uncertain significance Single submitter
- DTX1 p.Pro372Ser Uncertain significance Single submitter
- DTX1 p.Ser279Asn Uncertain significance Single submitter
- DTX1 p.Ser304Arg Uncertain significance Single submitter
- DTX1 p.Ser306Arg Uncertain significance Single submitter
- DTX1 p.Ser310Phe Uncertain significance Single submitter
- DTX1 p.Ser495Pro Uncertain significance Single submitter
- DTX1 p.Ser572Leu Uncertain significance Single submitter
- DTX1 p.Thr481Met Uncertain significance Single submitter
- DTX1 p.Thr565Met Uncertain significance Single submitter
- DTX1 p.Val305Glu Uncertain significance Single submitter
- DTX1 p.Val363Met Uncertain significance Single submitter
- DTX1 p.Val613Ile Uncertain significance Single submitter
-
DTX1 p.Gln68His
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All DTX1 variants
Benign 1
- p.Ser101= Multiple submitters
Likely benign 5
- p.Ala263Val Single submitter ⚠
- p.Gly281Ser Single submitter
- p.Pro277= Single submitter
- p.Pro596= Single submitter
- p.Gln68His No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 77
- p.Gly445Asp Multiple submitters ⚠
- p.Ala226Glu Single submitter ⚠
- p.Ala226Thr Single submitter ⚠
- p.Ala256Ser Single submitter ⚠
- p.Ala260Val Single submitter ⚠
- p.Ala267Pro Single submitter ⚠
- p.Ala275Val Single submitter ⚠
- p.Ala307Val Single submitter ⚠
- p.Ala42Val Single submitter ⚠
- p.Ala529Thr Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg296Pro Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Arg549Leu Single submitter ⚠
- p.Arg83His Single submitter ⚠
- p.Asn154Tyr Single submitter ⚠
- p.Asn405Ile Single submitter ⚠
- p.Asn459Ser Single submitter ⚠
- p.Asn578Lys Single submitter ⚠
- p.Asp367Glu Single submitter ⚠
- p.Asp510Asn Single submitter ⚠
- p.Asp510Gly Single submitter ⚠
- p.Cys378Ser Single submitter ⚠
- p.Gln68Arg Single submitter ⚠
- p.Glu425Gln Single submitter ⚠
- p.Glu436Asp Single submitter ⚠
- p.Glu477Lys Single submitter ⚠
- p.Glu615Asp Single submitter ⚠
- p.Gly115Cys Single submitter ⚠
- p.Gly285Glu Single submitter ⚠
- p.Gly426Asp Single submitter ⚠
- p.Gly432Val Single submitter ⚠
- p.Gly498Ser Single submitter ⚠
- p.Gly524Arg Single submitter ⚠
- p.Gly570Asp Single submitter ⚠
- p.Gly58Ser Single submitter ⚠
- p.Gly594Ser Single submitter ⚠
- p.His34Pro Single submitter ⚠
- p.His494Asp Single submitter ⚠
- p.His520Tyr Single submitter ⚠
- p.Ile311Phe Single submitter ⚠
- p.Ile311Val Single submitter ⚠
- p.Ile357Phe Single submitter ⚠
- p.Ile511Phe Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Lys383Glu Single submitter ⚠
- p.Phe527Leu Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Pro238Arg Single submitter ⚠
- p.Pro271Ala Single submitter ⚠
- p.Pro297Arg Single submitter ⚠
- p.Pro299His Single submitter ⚠
- p.Pro347Thr Single submitter ⚠
- p.Pro361Thr Single submitter ⚠
- p.Pro372Ser Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Pro483Leu Single submitter ⚠
- p.Ser279Asn Single submitter ⚠
- p.Ser304Arg Single submitter ⚠
- p.Ser306Arg Single submitter ⚠
- p.Ser310Phe Single submitter ⚠
- p.Ser495Pro Single submitter ⚠
- p.Ser572Leu Single submitter ⚠
- p.Thr288Pro Single submitter ⚠
- p.Thr303Ser Single submitter ⚠
- p.Thr481Met Single submitter ⚠
- p.Thr565Met Single submitter ⚠
- p.Thr591Met Single submitter ⚠
- p.Tyr424Phe Single submitter ⚠
- p.Tyr595His Single submitter ⚠
- p.Val22Leu Single submitter ⚠
- p.Val305Glu Single submitter ⚠
- p.Val363Met Single submitter ⚠
- p.Val368Leu Single submitter ⚠
- p.Val438Met Single submitter ⚠
- p.Val613Ile Single submitter ⚠