DTX2 — 123 ClinVar variants
All ClinVar germline DTX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
2 Benign · 13 Likely benign · 108 Uncertain significance
Full DTX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTX2 p.Ala17Thr Uncertain significance Single submitter
- DTX2 p.Ala187Ser Uncertain significance Single submitter
- DTX2 p.Ala195Ser Uncertain significance Single submitter
- DTX2 p.Ala258Val Uncertain significance Single submitter
- DTX2 p.Ala269Thr Uncertain significance Single submitter
- DTX2 p.Ala355Thr Uncertain significance Single submitter
- DTX2 p.Ala363Thr Uncertain significance Single submitter
- DTX2 p.Ala385Glu Uncertain significance Single submitter
- DTX2 p.Ala448Val Uncertain significance Single submitter
- DTX2 p.Arg213Gly Uncertain significance Single submitter
- DTX2 p.Arg281His Uncertain significance Single submitter
- DTX2 p.Arg354Cys Uncertain significance Single submitter
- DTX2 p.Arg354His Uncertain significance Single submitter
- DTX2 p.Arg535Cys Uncertain significance Single submitter
- DTX2 p.Arg53Cys Uncertain significance Single submitter
- DTX2 p.Asp118Asn Uncertain significance Single submitter
- DTX2 p.Asp409Glu Uncertain significance Single submitter
- DTX2 p.Asp598Asn Uncertain significance Single submitter
- DTX2 p.Gln228His Uncertain significance Single submitter
- DTX2 p.Gly27Glu Uncertain significance Single submitter
- DTX2 p.Gly435Arg Uncertain significance Single submitter
- DTX2 p.Gly515Asp Uncertain significance Single submitter
- DTX2 p.Gly595Ser Uncertain significance Single submitter
- DTX2 p.Gly613Val Uncertain significance Single submitter
- DTX2 p.His216Arg Uncertain significance Single submitter
- DTX2 p.His216Gln Uncertain significance Single submitter
- DTX2 p.His232Tyr Uncertain significance Single submitter
-
DTX2 p.His500Tyr
Uncertain significance
Single submitter
Inborn genetic diseases
- DTX2 p.His514Arg Uncertain significance Single submitter
- DTX2 p.His98Arg Uncertain significance Single submitter
- DTX2 p.Ile185Thr Uncertain significance Single submitter
- DTX2 p.Ile414Asn Uncertain significance Single submitter
- DTX2 p.Leu65Val Uncertain significance Single submitter
- DTX2 p.Lys388Gln Uncertain significance Single submitter
- DTX2 p.Met457Thr Uncertain significance Single submitter
- DTX2 p.Pro188Leu Uncertain significance Single submitter
- DTX2 p.Pro189Leu Uncertain significance Single submitter
- DTX2 p.Pro231Arg Uncertain significance Single submitter
- DTX2 p.Pro231Gln Uncertain significance Single submitter
- DTX2 p.Pro231Leu Uncertain significance Single submitter
- DTX2 p.Pro246Leu Uncertain significance Single submitter
- DTX2 p.Pro271Leu Uncertain significance Single submitter
- DTX2 p.Pro271Ser Uncertain significance Single submitter
- DTX2 p.Pro289Gln Uncertain significance Single submitter
- DTX2 p.Pro314Ala Uncertain significance Single submitter
- DTX2 p.Pro356Ala Uncertain significance Single submitter
- DTX2 p.Pro358Ser Uncertain significance Single submitter
- DTX2 p.Pro389Ala Uncertain significance Single submitter
- DTX2 p.Ser127Gly Uncertain significance Single submitter
- DTX2 p.Ser35Gly Uncertain significance Single submitter
- DTX2 p.Ser58Arg Uncertain significance Single submitter
- DTX2 p.Ser6Gly Uncertain significance Single submitter
- DTX2 p.Thr207Ile Uncertain significance Single submitter
- DTX2 p.Thr30Ile Uncertain significance Single submitter
- DTX2 p.Thr429Ile Uncertain significance Single submitter
- DTX2 p.Thr89Pro Uncertain significance Single submitter
- DTX2 p.Tyr476Cys Uncertain significance Single submitter
- DTX2 p.Val10Gly Uncertain significance Single submitter
- DTX2 p.Val111Ile Uncertain significance Single submitter
- DTX2 p.Val12Met Uncertain significance Single submitter
- DTX2 p.Val237Gly Uncertain significance Single submitter
- DTX2 p.Val331Leu Uncertain significance Single submitter
- DTX2 p.Val605Ala Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- DTX2 p.Ala146Asp Uncertain significance Single submitter
- DTX2 p.Ala255Gly Uncertain significance Single submitter
- DTX2 p.Ala456Ser Uncertain significance Single submitter
- DTX2 p.Arg108Gln Uncertain significance Single submitter
- DTX2 p.Arg173Gln Uncertain significance Single submitter
- DTX2 p.Arg174Cys Uncertain significance Single submitter
- DTX2 p.Arg174His Uncertain significance Single submitter
- DTX2 p.Arg213Cys Uncertain significance Single submitter
- DTX2 p.Arg215His Uncertain significance Single submitter
- DTX2 p.Arg86Cys Uncertain significance Single submitter
- DTX2 p.Arg93Gln Uncertain significance Single submitter
- DTX2 p.Asn155Ser Uncertain significance Single submitter
- DTX2 p.Asn460Asp Uncertain significance Single submitter
- DTX2 p.Asn600Ser Uncertain significance Single submitter
- DTX2 p.Asp117Asn Uncertain significance Single submitter
- DTX2 p.Cys618Trp Uncertain significance Single submitter
- DTX2 p.Gln134Glu Uncertain significance Single submitter
- DTX2 p.Gln135His Uncertain significance Single submitter
- DTX2 p.Gln44Leu Uncertain significance Single submitter
- DTX2 p.Glu410Lys Uncertain significance Single submitter
- DTX2 p.Gly208Asp Uncertain significance Single submitter
- DTX2 p.Gly254Arg Uncertain significance Single submitter
- DTX2 p.Gly372Cys Uncertain significance Single submitter
- DTX2 p.Gly435Val Uncertain significance Single submitter
- DTX2 p.Gly499Ser Uncertain significance Single submitter
- DTX2 p.His229Asp Uncertain significance Single submitter
- DTX2 p.His441Tyr Uncertain significance Single submitter
- DTX2 p.Ile413Asn Uncertain significance Single submitter
- DTX2 p.Leu279Ile Uncertain significance Single submitter
- DTX2 p.Leu437Pro Uncertain significance Single submitter
- DTX2 p.Met338Ile Uncertain significance Single submitter
- DTX2 p.Phe54Leu Uncertain significance Single submitter
- DTX2 p.Pro222His Uncertain significance Single submitter
- DTX2 p.Pro250Leu Uncertain significance Single submitter
- DTX2 p.Pro74Thr Uncertain significance Single submitter
- DTX2 p.Ser167Ile Uncertain significance Single submitter
- DTX2 p.Ser312Arg Uncertain significance Single submitter
- DTX2 p.Thr219Ile Uncertain significance Single submitter
- DTX2 p.Thr339Met Uncertain significance Single submitter
- DTX2 p.Thr480Met Uncertain significance Single submitter
- DTX2 p.Thr573Met Uncertain significance Single submitter
- DTX2 p.Thr91Ala Uncertain significance Single submitter
- DTX2 p.Val143Met Uncertain significance Single submitter
- DTX2 p.Val210Met Uncertain significance Single submitter
- DTX2 p.Val317Ile Likely benign Single submitter
- DTX2 p.Val38Ile Uncertain significance Single submitter
All DTX2 variants
Benign 2
- p.Pro484= Multiple submitters
- c.1390-5G>C Single submitter
Likely benign 13
- p.Ala422= Multiple submitters
- p.Gly515= Multiple submitters
- p.Ala17Val Single submitter
- p.Asn542= Single submitter
- p.Gly300Ser Single submitter
- p.His441Arg Single submitter
- p.Leu142= Single submitter
- p.Lys398Arg Single submitter
- p.Pro230= Single submitter
- p.Pro524= Single submitter
- p.Ser436Pro Single submitter
- p.Thr157Ala Single submitter
- p.Val317Ile Single submitter ⚠
Uncertain significance 108
- p.Ala146Asp Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala187Ser Single submitter ⚠
- p.Ala195Ser Single submitter ⚠
- p.Ala255Gly Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala363Thr Single submitter ⚠
- p.Ala385Glu Single submitter ⚠
- p.Ala448Val Single submitter ⚠
- p.Ala456Ser Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg173Gln Single submitter ⚠
- p.Arg174Cys Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg213Cys Single submitter ⚠
- p.Arg213Gly Single submitter ⚠
- p.Arg215His Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg354Cys Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg535Cys Single submitter ⚠
- p.Arg53Cys Single submitter ⚠
- p.Arg86Cys Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asn460Asp Single submitter ⚠
- p.Asn600Ser Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp118Asn Single submitter ⚠
- p.Asp409Glu Single submitter ⚠
- p.Asp598Asn Single submitter ⚠
- p.Cys618Trp Single submitter ⚠
- p.Gln134Glu Single submitter ⚠
- p.Gln135His Single submitter ⚠
- p.Gln228His Single submitter ⚠
- p.Gln44Leu Single submitter ⚠
- p.Glu410Lys Single submitter ⚠
- p.Gly208Asp Single submitter ⚠
- p.Gly254Arg Single submitter ⚠
- p.Gly27Glu Single submitter ⚠
- p.Gly372Cys Single submitter ⚠
- p.Gly435Arg Single submitter ⚠
- p.Gly435Val Single submitter ⚠
- p.Gly499Ser Single submitter ⚠
- p.Gly515Asp Single submitter ⚠
- p.Gly595Ser Single submitter ⚠
- p.Gly613Val Single submitter ⚠
- p.His216Arg Single submitter ⚠
- p.His216Gln Single submitter ⚠
- p.His229Asp Single submitter ⚠
- p.His232Tyr Single submitter ⚠
- p.His441Tyr Single submitter ⚠
- p.His500Tyr Single submitter Inborn genetic diseases ⚠
- p.His514Arg Single submitter ⚠
- p.His98Arg Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile413Asn Single submitter ⚠
- p.Ile414Asn Single submitter ⚠
- p.Leu279Ile Single submitter ⚠
- p.Leu437Pro Single submitter ⚠
- p.Leu65Val Single submitter ⚠
- p.Lys388Gln Single submitter ⚠
- p.Met338Ile Single submitter ⚠
- p.Met457Thr Single submitter ⚠
- p.Phe54Leu Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro189Leu Single submitter ⚠
- p.Pro222His Single submitter ⚠
- p.Pro231Arg Single submitter ⚠
- p.Pro231Gln Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro289Gln Single submitter ⚠
- p.Pro314Ala Single submitter ⚠
- p.Pro356Ala Single submitter ⚠
- p.Pro358Ser Single submitter ⚠
- p.Pro389Ala Single submitter ⚠
- p.Pro74Thr Single submitter ⚠
- p.Ser127Gly Single submitter ⚠
- p.Ser167Ile Single submitter ⚠
- p.Ser312Arg Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser58Arg Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Thr207Ile Single submitter ⚠
- p.Thr219Ile Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Thr339Met Single submitter ⚠
- p.Thr429Ile Single submitter ⚠
- p.Thr480Met Single submitter ⚠
- p.Thr573Met Single submitter ⚠
- p.Thr89Pro Single submitter ⚠
- p.Thr91Ala Single submitter ⚠
- p.Tyr476Cys Single submitter ⚠
- p.Val10Gly Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val12Met Single submitter ⚠
- p.Val143Met Single submitter ⚠
- p.Val210Met Single submitter ⚠
- p.Val237Gly Single submitter ⚠
- p.Val331Leu Single submitter ⚠
- p.Val38Ile Single submitter ⚠
- p.Val605Ala Single submitter ⚠