DTX3L — 106 ClinVar variants
All ClinVar germline DTX3L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
1 Benign · 15 Likely benign · 90 Uncertain significance
Full DTX3L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTX3L p.Ala370Val Uncertain significance Single submitter
- DTX3L p.Ala383Thr Uncertain significance Single submitter
- DTX3L p.Arg216Thr Uncertain significance Single submitter
- DTX3L p.Arg291His Uncertain significance Single submitter
- DTX3L p.Arg477Gly Uncertain significance Single submitter
- DTX3L p.Arg671Lys Uncertain significance Single submitter
- DTX3L p.Arg693Cys Uncertain significance Single submitter
- DTX3L p.Asn255Ser Uncertain significance Single submitter
- DTX3L p.Asn650Lys Uncertain significance Single submitter
- DTX3L p.Cys144Arg Uncertain significance Single submitter
- DTX3L p.Cys309Tyr Uncertain significance Single submitter
- DTX3L p.Cys561Tyr Uncertain significance Single submitter
- DTX3L p.Gln108Glu Uncertain significance Single submitter
- DTX3L p.Gln118Glu Uncertain significance Single submitter
- DTX3L p.Gln268Arg Uncertain significance Single submitter
- DTX3L p.Gln299Arg Uncertain significance Single submitter
- DTX3L p.Gln347His Uncertain significance Single submitter
- DTX3L p.Gln414Arg Uncertain significance Single submitter
- DTX3L p.Glu194Gly Uncertain significance Single submitter
- DTX3L p.Glu336Lys Uncertain significance Single submitter
- DTX3L p.Glu40Lys Uncertain significance Single submitter
- DTX3L p.Glu628Lys Uncertain significance Single submitter
- DTX3L p.Gly19Asp Uncertain significance Single submitter
- DTX3L p.Gly509Glu Uncertain significance Single submitter
- DTX3L p.Gly715Arg Uncertain significance Single submitter
- DTX3L p.His117Arg Uncertain significance Single submitter
- DTX3L p.His524Leu Uncertain significance Single submitter
- DTX3L p.His524Tyr Uncertain significance Single submitter
- DTX3L p.His579Leu Uncertain significance Single submitter
- DTX3L p.Ile123Thr Uncertain significance Single submitter
- DTX3L p.Ile123Val Uncertain significance Single submitter
- DTX3L p.Ile265Val Uncertain significance Single submitter
- DTX3L p.Ile378Thr Uncertain significance Single submitter
- DTX3L p.Ile633Val Uncertain significance Single submitter
- DTX3L p.Leu453His Uncertain significance Single submitter
- DTX3L p.Leu453Phe Uncertain significance Single submitter
- DTX3L p.Leu677Arg Uncertain significance Single submitter
- DTX3L p.Leu685Gln Uncertain significance Single submitter
- DTX3L p.Lys34Thr Uncertain significance Single submitter
- DTX3L p.Lys412Glu Uncertain significance Single submitter
- DTX3L p.Lys423Arg Uncertain significance Single submitter
- DTX3L p.Lys469Gln Uncertain significance Single submitter
- DTX3L p.Lys469Met Uncertain significance Single submitter
- DTX3L p.Lys503Arg Uncertain significance Single submitter
- DTX3L p.Lys572Thr Uncertain significance Single submitter
- DTX3L p.Met274Thr Uncertain significance Single submitter
- DTX3L p.Phe30Leu Uncertain significance Single submitter
- DTX3L p.Phe687Val Uncertain significance Single submitter
- DTX3L p.Pro112Leu Uncertain significance Single submitter
- DTX3L p.Pro225Ser Uncertain significance Single submitter
- DTX3L p.Pro251Leu Uncertain significance Single submitter
- DTX3L p.Pro527Leu Uncertain significance Single submitter
- DTX3L p.Pro594Ser Uncertain significance Single submitter
- DTX3L p.Pro651Ala Uncertain significance Single submitter
- DTX3L p.Pro83Ser Uncertain significance Single submitter
- DTX3L p.Pro88Leu Uncertain significance Single submitter
- DTX3L p.Ser103Leu Uncertain significance Single submitter
- DTX3L p.Ser212Gly Uncertain significance Single submitter
- DTX3L p.Ser270Arg Uncertain significance Single submitter
- DTX3L p.Ser35Pro Uncertain significance Single submitter
- DTX3L p.Ser532Asn Uncertain significance Single submitter
- DTX3L p.Ser614Gly Uncertain significance Single submitter
- DTX3L p.Thr139Ile Uncertain significance Single submitter
- DTX3L p.Thr156Ile Uncertain significance Single submitter
- DTX3L p.Thr302Ile Uncertain significance Single submitter
- DTX3L p.Thr601Ala Uncertain significance Single submitter
- DTX3L p.Thr710Ile Uncertain significance Single submitter
- DTX3L p.Tyr373Asn Uncertain significance Single submitter
- DTX3L p.Tyr592Cys Uncertain significance Single submitter
- DTX3L p.Val484Met Uncertain significance Single submitter
- DTX3L p.Val616Phe Uncertain significance Single submitter
- DTX3L p.Val694Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- DTX3L p.Arg729Cys Uncertain significance Single submitter
- DTX3L p.Glu150Gly Uncertain significance Single submitter
- DTX3L p.Glu400Lys Uncertain significance Single submitter
- DTX3L p.Glu580Asp Uncertain significance Single submitter
- DTX3L p.Ile162Asn Uncertain significance Single submitter
- DTX3L p.Leu343Val Uncertain significance Single submitter
- DTX3L p.Leu624Phe Uncertain significance Single submitter
- DTX3L p.Phe681Leu Uncertain significance Single submitter
- DTX3L p.Pro160Leu Uncertain significance Single submitter
- DTX3L p.Ser161Ile Uncertain significance Single submitter
- DTX3L p.Ser32Thr Uncertain significance Single submitter
- DTX3L p.Ser397Pro Uncertain significance Single submitter
- DTX3L p.Tyr385Cys Uncertain significance Single submitter
- DTX3L p.Tyr603Cys Uncertain significance Single submitter
- DTX3L p.Val56Leu Uncertain significance Single submitter
- DTX3L p.Val67Leu Uncertain significance Single submitter
All DTX3L variants
Benign 1
- p.Gly459Val Multiple submitters
Likely benign 15
- p.Ala583Thr Single submitter
- p.Arg477Lys Single submitter
- p.Asp169Asn Single submitter
- p.Asp533Asn Single submitter
- p.Asp78= Single submitter
- p.Glu732= Single submitter
- p.Glu732Gln Single submitter
- p.His4= Single submitter
- p.Ile162Val Single submitter
- p.Leu553Val Single submitter
- p.Pro304Ser Single submitter
- p.Pro540Leu Single submitter
- p.Ser204Leu Single submitter
- p.Ser514Pro Single submitter
- p.Thr97Met Single submitter
Uncertain significance 90
- p.Ala370Val Single submitter ⚠
- p.Ala383Thr Single submitter ⚠
- p.Arg216Thr Single submitter ⚠
- p.Arg291His Single submitter ⚠
- p.Arg477Gly Single submitter ⚠
- p.Arg671Lys Single submitter ⚠
- p.Arg693Cys Single submitter ⚠
- p.Arg729Cys Single submitter ⚠
- p.Arg729His Single submitter
- p.Asn255Ser Single submitter ⚠
- p.Asn650Lys Single submitter ⚠
- p.Cys144Arg Single submitter ⚠
- p.Cys309Tyr Single submitter ⚠
- p.Cys561Tyr Single submitter ⚠
- p.Gln108Glu Single submitter ⚠
- p.Gln118Glu Single submitter ⚠
- p.Gln268Arg Single submitter ⚠
- p.Gln299Arg Single submitter ⚠
- p.Gln347His Single submitter ⚠
- p.Gln414Arg Single submitter ⚠
- p.Glu150Gly Single submitter ⚠
- p.Glu194Gly Single submitter ⚠
- p.Glu336Lys Single submitter ⚠
- p.Glu400Lys Single submitter ⚠
- p.Glu40Lys Single submitter ⚠
- p.Glu580Asp Single submitter ⚠
- p.Glu628Lys Single submitter ⚠
- p.Gly19Asp Single submitter ⚠
- p.Gly509Glu Single submitter ⚠
- p.Gly715Arg Single submitter ⚠
- p.His117Arg Single submitter ⚠
- p.His524Leu Single submitter ⚠
- p.His524Tyr Single submitter ⚠
- p.His579Leu Single submitter ⚠
- p.Ile123Thr Single submitter ⚠
- p.Ile123Val Single submitter ⚠
- p.Ile162Asn Single submitter ⚠
- p.Ile265Val Single submitter ⚠
- p.Ile378Thr Single submitter ⚠
- p.Ile633Val Single submitter ⚠
- p.Leu343Val Single submitter ⚠
- p.Leu453His Single submitter ⚠
- p.Leu453Phe Single submitter ⚠
- p.Leu624Phe Single submitter ⚠
- p.Leu676Arg Single submitter
- p.Leu677Arg Single submitter ⚠
- p.Leu685Gln Single submitter ⚠
- p.Lys34Thr Single submitter ⚠
- p.Lys412Glu Single submitter ⚠
- p.Lys423Arg Single submitter ⚠
- p.Lys469Gln Single submitter ⚠
- p.Lys469Met Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Lys572Thr Single submitter ⚠
- p.Met274Thr Single submitter ⚠
- p.Phe30Leu Single submitter ⚠
- p.Phe681Leu Single submitter ⚠
- p.Phe687Val Single submitter ⚠
- p.Pro112Leu Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro527Leu Single submitter ⚠
- p.Pro594Ser Single submitter ⚠
- p.Pro651Ala Single submitter ⚠
- p.Pro83Ser Single submitter ⚠
- p.Pro88Leu Single submitter ⚠
- p.Ser103Leu Single submitter ⚠
- p.Ser161Ile Single submitter ⚠
- p.Ser212Gly Single submitter ⚠
- p.Ser270Arg Single submitter ⚠
- p.Ser32Thr Single submitter ⚠
- p.Ser35Pro Single submitter ⚠
- p.Ser397Pro Single submitter ⚠
- p.Ser532Asn Single submitter ⚠
- p.Ser614Gly Single submitter ⚠
- p.Thr139Ile Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr302Ile Single submitter ⚠
- p.Thr601Ala Single submitter ⚠
- p.Thr710Ile Single submitter ⚠
- p.Tyr373Asn Single submitter ⚠
- p.Tyr385Cys Single submitter ⚠
- p.Tyr592Cys Single submitter ⚠
- p.Tyr603Cys Single submitter ⚠
- p.Val484Met Single submitter ⚠
- p.Val56Leu Single submitter ⚠
- p.Val616Phe Single submitter ⚠
- p.Val67Leu Single submitter ⚠
- p.Val694Ile Single submitter ⚠