DTX4 — 88 ClinVar variants
All ClinVar germline DTX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
4 Benign · 1 Likely benign · 83 Uncertain significance
Full DTX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DTX4 p.Ala171Thr Uncertain significance Single submitter
- DTX4 p.Ala288Pro Uncertain significance Single submitter
- DTX4 p.Ala303Gly Uncertain significance Single submitter
- DTX4 p.Ala310Thr Uncertain significance Single submitter
- DTX4 p.Ala40Gly Uncertain significance Single submitter
- DTX4 p.Ala606Val Uncertain significance Single submitter
- DTX4 p.Ala615Asp Uncertain significance Single submitter
- DTX4 p.Ala86Val Uncertain significance Single submitter
- DTX4 p.Arg145His Uncertain significance Single submitter
- DTX4 p.Arg218Cys Uncertain significance Single submitter
- DTX4 p.Arg218His Uncertain significance Single submitter
- DTX4 p.Arg415His Uncertain significance Single submitter
- DTX4 p.Arg502Gln Uncertain significance Single submitter
- DTX4 p.Arg52Gly Uncertain significance Single submitter
- DTX4 p.Arg553Cys Uncertain significance Single submitter
- DTX4 p.Arg74His Uncertain significance Single submitter
- DTX4 p.Arg78Cys Uncertain significance Single submitter
- DTX4 p.Arg78Pro Uncertain significance Single submitter
- DTX4 p.Asn206Thr Uncertain significance Single submitter
- DTX4 p.Asn296Thr Uncertain significance Single submitter
- DTX4 p.Asn518His Uncertain significance Single submitter
- DTX4 p.Asn99His Uncertain significance Single submitter
- DTX4 p.Asp82His Uncertain significance Single submitter
- DTX4 p.Glu392Gln Uncertain significance Single submitter
- DTX4 p.Glu407Gly Uncertain significance Single submitter
- DTX4 p.Glu567Lys Uncertain significance Single submitter
- DTX4 p.Glu603Gln Uncertain significance Single submitter
- DTX4 p.Gly285Arg Uncertain significance Single submitter
- DTX4 p.Gly42Ser Uncertain significance Single submitter
- DTX4 p.His490Pro Uncertain significance Single submitter
- DTX4 p.Ile160Phe Uncertain significance Single submitter
- DTX4 p.Ile160Val Uncertain significance Single submitter
- DTX4 p.Ile446Leu Uncertain significance Single submitter
- DTX4 p.Leu229Val Uncertain significance Single submitter
- DTX4 p.Leu240Pro Uncertain significance Single submitter
- DTX4 p.Met198Ile Uncertain significance Single submitter
- DTX4 p.Met271Ile Uncertain significance Single submitter
- DTX4 p.Pro178Leu Uncertain significance Single submitter
- DTX4 p.Pro184Thr Uncertain significance Single submitter
- DTX4 p.Pro222Leu Uncertain significance Single submitter
- DTX4 p.Pro231Leu Uncertain significance Single submitter
- DTX4 p.Pro233Ser Uncertain significance Single submitter
- DTX4 p.Pro38Leu Uncertain significance Single submitter
- DTX4 p.Pro425Arg Uncertain significance Single submitter
- DTX4 p.Pro479Leu Uncertain significance Single submitter
- DTX4 p.Pro496Thr Uncertain significance Single submitter
- DTX4 p.Ser101Cys Uncertain significance Single submitter
- DTX4 p.Ser199Asn Uncertain significance Single submitter
- DTX4 p.Ser23Asn Uncertain significance Single submitter
- DTX4 p.Ser613Asn Uncertain significance Single submitter
- DTX4 p.Ser85Leu Uncertain significance Single submitter
- DTX4 p.Thr103Met Uncertain significance Single submitter
- DTX4 p.Thr417Met Uncertain significance Single submitter
- DTX4 p.Thr70Arg Uncertain significance Single submitter
- DTX4 p.Tyr105Cys Uncertain significance Single submitter
- DTX4 p.Tyr397Cys Uncertain significance Single submitter
- DTX4 p.Val153Ile Uncertain significance Single submitter
- DTX4 p.Val34Ile Uncertain significance Single submitter
- DTX4 p.Ser325Asn Uncertain significance No assertion criteria
Predictors split 20
The independent predictors disagree with each other — read with care.
- DTX4 p.Ala525Thr Uncertain significance Single submitter
- DTX4 p.Arg149His Uncertain significance Single submitter
- DTX4 p.Arg152Cys Uncertain significance Single submitter
- DTX4 p.Arg154Cys Uncertain significance Single submitter
- DTX4 p.Arg155Gln Uncertain significance Single submitter
- DTX4 p.Arg306Trp Uncertain significance Single submitter
- DTX4 p.Arg377His Uncertain significance Single submitter
- DTX4 p.Arg402Trp Uncertain significance Single submitter
- DTX4 p.Arg526Gln Uncertain significance Single submitter
- DTX4 p.Asp69Val Uncertain significance Single submitter
- DTX4 p.Cys194Arg Uncertain significance Single submitter
- DTX4 p.Glu15Lys Uncertain significance Single submitter
- DTX4 p.Gly42Arg Uncertain significance Single submitter
- DTX4 p.His486Gln Uncertain significance Single submitter
- DTX4 p.Ile129Thr Uncertain significance Single submitter
- DTX4 p.Ile366Thr Uncertain significance Single submitter
- DTX4 p.Lys353Gln Uncertain significance Single submitter
- DTX4 p.Ser491Tyr Uncertain significance Single submitter
- DTX4 p.Thr70Ser Uncertain significance Single submitter
- DTX4 p.Tyr80His Uncertain significance Single submitter
All DTX4 variants
Benign 4
- p.Ala342= Multiple submitters
- p.Thr284= Multiple submitters
- p.Val257Gly Multiple submitters
- p.Val355= Multiple submitters
Likely benign 1
- p.Leu232Pro Single submitter
Uncertain significance 83
- p.Ala171Thr Single submitter ⚠
- p.Ala288Pro Single submitter ⚠
- p.Ala303Gly Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala40Gly Single submitter ⚠
- p.Ala525Thr Single submitter ⚠
- p.Ala606Val Single submitter ⚠
- p.Ala615Asp Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg155Trp Single submitter
- p.Arg218Cys Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Arg377His Single submitter ⚠
- p.Arg402Trp Single submitter ⚠
- p.Arg415His Single submitter ⚠
- p.Arg502Gln Single submitter ⚠
- p.Arg526Gln Single submitter ⚠
- p.Arg52Gly Single submitter ⚠
- p.Arg553Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Arg78Pro Single submitter ⚠
- p.Asn206Thr Single submitter ⚠
- p.Asn296Thr Single submitter ⚠
- p.Asn518His Single submitter ⚠
- p.Asn99His Single submitter ⚠
- p.Asp69Val Single submitter ⚠
- p.Asp82His Single submitter ⚠
- p.Cys194Arg Single submitter ⚠
- p.Gln120Pro Single submitter
- p.Glu15Lys Single submitter ⚠
- p.Glu392Gln Single submitter ⚠
- p.Glu407Gly Single submitter ⚠
- p.Glu567Lys Single submitter ⚠
- p.Glu603Gln Single submitter ⚠
- p.Gly285Arg Single submitter ⚠
- p.Gly42Arg Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.His486Gln Single submitter ⚠
- p.His490Pro Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile160Phe Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile366Thr Single submitter ⚠
- p.Ile446Leu Single submitter ⚠
- p.Leu229Val Single submitter ⚠
- p.Leu240Pro Single submitter ⚠
- p.Leu597Val Single submitter
- p.Lys353Gln Single submitter ⚠
- p.Met198Ile Single submitter ⚠
- p.Met271Ile Single submitter ⚠
- p.Pro178Leu Single submitter ⚠
- p.Pro184Thr Single submitter ⚠
- p.Pro222Leu Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro233Ser Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro425Arg Single submitter ⚠
- p.Pro479Leu Single submitter ⚠
- p.Pro496Thr Single submitter ⚠
- p.Ser101Cys Single submitter ⚠
- p.Ser199Asn Single submitter ⚠
- p.Ser23Asn Single submitter ⚠
- p.Ser491Tyr Single submitter ⚠
- p.Ser613Asn Single submitter ⚠
- p.Ser85Leu Single submitter ⚠
- p.Thr103Met Single submitter ⚠
- p.Thr417Met Single submitter ⚠
- p.Thr70Arg Single submitter ⚠
- p.Thr70Ser Single submitter ⚠
- p.Tyr105Cys Single submitter ⚠
- p.Tyr397Cys Single submitter ⚠
- p.Tyr80His Single submitter ⚠
- p.Val153Ile Single submitter ⚠
- p.Val34Ile Single submitter ⚠
- p.Val571Ile Single submitter
- p.Ser325Asn No assertion criteria ⚠