DUS3L — 127 ClinVar variants
All ClinVar germline DUS3L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 112 flagged for review →
7 Likely benign · 120 Uncertain significance
Full DUS3L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 112
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUS3L p.Ala133Thr Uncertain significance Single submitter
- DUS3L p.Ala244Ser Uncertain significance Single submitter
- DUS3L p.Ala251Val Uncertain significance Single submitter
- DUS3L p.Ala329Val Uncertain significance Single submitter
- DUS3L p.Ala369Thr Uncertain significance Single submitter
- DUS3L p.Ala460Gly Uncertain significance Single submitter
- DUS3L p.Ala639Thr Uncertain significance Single submitter
- DUS3L p.Arg104Gln Uncertain significance Single submitter
- DUS3L p.Arg149Cys Uncertain significance Single submitter
- DUS3L p.Arg161His Uncertain significance Single submitter
- DUS3L p.Arg178Cys Uncertain significance Single submitter
- DUS3L p.Arg233Cys Uncertain significance Single submitter
- DUS3L p.Arg233His Uncertain significance Single submitter
- DUS3L p.Arg256Lys Uncertain significance Single submitter
- DUS3L p.Arg300Gln Uncertain significance Single submitter
- DUS3L p.Arg300Trp Uncertain significance Single submitter
- DUS3L p.Arg304His Uncertain significance Single submitter
- DUS3L p.Arg422His Uncertain significance Single submitter
- DUS3L p.Arg437His Uncertain significance Single submitter
- DUS3L p.Arg443His Uncertain significance Single submitter
- DUS3L p.Arg455Gln Uncertain significance Single submitter
- DUS3L p.Arg469Gln Uncertain significance Single submitter
- DUS3L p.Arg472His Uncertain significance Single submitter
- DUS3L p.Arg508His Uncertain significance Single submitter
- DUS3L p.Arg572Gln Uncertain significance Single submitter
- DUS3L p.Arg584Trp Uncertain significance Single submitter
- DUS3L p.Arg593Gln Uncertain significance Single submitter
- DUS3L p.Arg608Cys Uncertain significance Single submitter
- DUS3L p.Asn117Ile Uncertain significance Single submitter
- DUS3L p.Asn190His Uncertain significance Single submitter
- DUS3L p.Asn507Ser Uncertain significance Single submitter
- DUS3L p.Asn555Thr Uncertain significance Single submitter
- DUS3L p.Asp139Gly Uncertain significance Single submitter
- DUS3L p.Asp17Glu Uncertain significance Single submitter
- DUS3L p.Asp289Asn Uncertain significance Single submitter
- DUS3L p.Asp478Asn Uncertain significance Single submitter
- DUS3L p.Cys485Tyr Uncertain significance Single submitter
- DUS3L p.Gln106Glu Uncertain significance Single submitter
- DUS3L p.Gln263Pro Uncertain significance Single submitter
- DUS3L p.Gln419Arg Uncertain significance Single submitter
- DUS3L p.Gln596Pro Uncertain significance Single submitter
- DUS3L p.Gln96Pro Uncertain significance Single submitter
- DUS3L p.Gln98His Uncertain significance Single submitter
- DUS3L p.Glu226Lys Uncertain significance Single submitter
- DUS3L p.Glu349Lys Uncertain significance Single submitter
- DUS3L p.Glu453Lys Uncertain significance Single submitter
- DUS3L p.Glu483Lys Uncertain significance Single submitter
- DUS3L p.Glu577Gln Uncertain significance Single submitter
- DUS3L p.Gly16Ser Uncertain significance Single submitter
- DUS3L p.Gly174Ser Uncertain significance Single submitter
- DUS3L p.Gly328Arg Uncertain significance Single submitter
- DUS3L p.Gly395Ser Uncertain significance Single submitter
- DUS3L p.His145Gln Uncertain significance Single submitter
- DUS3L p.Ile206Leu Uncertain significance Single submitter
- DUS3L p.Ile303Val Uncertain significance Single submitter
- DUS3L p.Ile323Thr Uncertain significance Single submitter
- DUS3L p.Ile392Val Uncertain significance Single submitter
- DUS3L p.Ile436Leu Uncertain significance Single submitter
- DUS3L p.Ile626Leu Uncertain significance Single submitter
- DUS3L p.Leu218Pro Uncertain significance Single submitter
- DUS3L p.Leu35Val Uncertain significance Single submitter
- DUS3L p.Leu67Val Uncertain significance Single submitter
- DUS3L p.Leu77Val Uncertain significance Single submitter
- DUS3L p.Lys52Thr Uncertain significance Single submitter
- DUS3L p.Met374Leu Uncertain significance Single submitter
- DUS3L p.Met492Leu Uncertain significance Single submitter
- DUS3L p.Pro186Ser Uncertain significance Single submitter
- DUS3L p.Pro241Leu Uncertain significance Single submitter
- DUS3L p.Pro274Leu Uncertain significance Single submitter
- DUS3L p.Pro642Leu Uncertain significance Single submitter
- DUS3L p.Ser18Leu Uncertain significance Single submitter
- DUS3L p.Thr281Ile Uncertain significance Single submitter
- DUS3L p.Thr474Ile Uncertain significance Single submitter
- DUS3L p.Thr99Ser Uncertain significance Single submitter
- DUS3L p.Trp528Arg Uncertain significance Single submitter
- DUS3L p.Tyr604His Uncertain significance Single submitter
- DUS3L p.Val175Met Uncertain significance Single submitter
- DUS3L p.Val364Ile Uncertain significance Single submitter
- DUS3L p.Val421Ile Uncertain significance Single submitter
- DUS3L p.Val440Ile Uncertain significance Single submitter
- DUS3L p.Val59Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- DUS3L p.Ala329Ser Uncertain significance Single submitter
- DUS3L p.Ala447Val Uncertain significance Single submitter
- DUS3L p.Ala488Thr Uncertain significance Single submitter
- DUS3L p.Ala648Glu Uncertain significance Single submitter
- DUS3L p.Ala648Gly Uncertain significance Single submitter
- DUS3L p.Ala648Val Uncertain significance Single submitter
- DUS3L p.Arg219Gln Uncertain significance Single submitter
- DUS3L p.Arg234Trp Uncertain significance Single submitter
- DUS3L p.Arg326His Uncertain significance Single submitter
- DUS3L p.Arg355Cys Uncertain significance Single submitter
- DUS3L p.Arg422Gly Uncertain significance Single submitter
- DUS3L p.Arg508Cys Uncertain significance Single submitter
- DUS3L p.Asn107Lys Uncertain significance Single submitter
- DUS3L p.Asn208Asp Uncertain significance Single submitter
- DUS3L p.Asn647Lys Uncertain significance Single submitter
- DUS3L p.Asp157Glu Uncertain significance Single submitter
- DUS3L p.Asp548Asn Uncertain significance Single submitter
- DUS3L p.Cys358Tyr Uncertain significance Single submitter
- DUS3L p.Cys583Tyr Uncertain significance Single submitter
- DUS3L p.Glu504Lys Uncertain significance Single submitter
- DUS3L p.Glu78Lys Uncertain significance Single submitter
- DUS3L p.Ile541Val Uncertain significance Single submitter
- DUS3L p.Phe143Leu Uncertain significance Single submitter
- DUS3L p.Pro493Ala Uncertain significance Single submitter
- DUS3L p.Pro493Leu Uncertain significance Single submitter
- DUS3L p.Ser542Leu Uncertain significance Single submitter
- DUS3L p.Thr613Met Uncertain significance Single submitter
- DUS3L p.Val223Ala Uncertain significance Single submitter
- DUS3L p.Val394Ile Uncertain significance Single submitter
- DUS3L p.Val401Met Uncertain significance Single submitter
- DUS3L p.Val588Met Uncertain significance Single submitter
All DUS3L variants
Likely benign 7
- p.Ala267Thr Single submitter
- p.Arg280Gln Single submitter
- p.Arg55Gln Single submitter
- p.Gly94Arg Single submitter
- p.Pro62Ser Single submitter
- p.Ser627= Single submitter
- p.Thr515= Single submitter
Uncertain significance 120
- p.Ala133Thr Single submitter ⚠
- p.Ala182Pro Single submitter
- p.Ala244Ser Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala329Ser Single submitter ⚠
- p.Ala329Val Single submitter ⚠
- p.Ala369Thr Single submitter ⚠
- p.Ala447Val Single submitter ⚠
- p.Ala460Gly Single submitter ⚠
- p.Ala488Thr Single submitter ⚠
- p.Ala639Thr Single submitter ⚠
- p.Ala648Glu Single submitter ⚠
- p.Ala648Gly Single submitter ⚠
- p.Ala648Val Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg178Cys Single submitter ⚠
- p.Arg219Gln Single submitter ⚠
- p.Arg233Cys Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg234Trp Single submitter ⚠
- p.Arg256Lys Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Arg300Trp Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg322Gln Single submitter
- p.Arg326His Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg422Gly Single submitter ⚠
- p.Arg422His Single submitter ⚠
- p.Arg437His Single submitter ⚠
- p.Arg443His Single submitter ⚠
- p.Arg455Gln Single submitter ⚠
- p.Arg469Gln Single submitter ⚠
- p.Arg472His Single submitter ⚠
- p.Arg508Cys Single submitter ⚠
- p.Arg508His Single submitter ⚠
- p.Arg572Gln Single submitter ⚠
- p.Arg584Trp Single submitter ⚠
- p.Arg593Gln Single submitter ⚠
- p.Arg608Cys Single submitter ⚠
- p.Asn107Lys Single submitter ⚠
- p.Asn117Ile Single submitter ⚠
- p.Asn190His Single submitter ⚠
- p.Asn208Asp Single submitter ⚠
- p.Asn507Ser Single submitter ⚠
- p.Asn555Thr Single submitter ⚠
- p.Asn647Lys Single submitter ⚠
- p.Asp139Gly Single submitter ⚠
- p.Asp157Asn Single submitter
- p.Asp157Glu Single submitter ⚠
- p.Asp17Glu Single submitter ⚠
- p.Asp289Asn Single submitter ⚠
- p.Asp478Asn Single submitter ⚠
- p.Asp548Asn Single submitter ⚠
- p.Cys358Tyr Single submitter ⚠
- p.Cys485Tyr Single submitter ⚠
- p.Cys583Tyr Single submitter ⚠
- p.Gln106Glu Single submitter ⚠
- p.Gln263Pro Single submitter ⚠
- p.Gln419Arg Single submitter ⚠
- p.Gln471Glu Single submitter
- p.Gln596Pro Single submitter ⚠
- p.Gln96Pro Single submitter ⚠
- p.Gln98His Single submitter ⚠
- p.Glu226Lys Single submitter ⚠
- p.Glu349Lys Single submitter ⚠
- p.Glu453Lys Single submitter ⚠
- p.Glu483Lys Single submitter ⚠
- p.Glu504Lys Single submitter ⚠
- p.Glu577Gln Single submitter ⚠
- p.Glu78Lys Single submitter ⚠
- p.Gly159Val Single submitter
- p.Gly16Ser Single submitter ⚠
- p.Gly174Ser Single submitter ⚠
- p.Gly328Arg Single submitter ⚠
- p.Gly395Ser Single submitter ⚠
- p.Gly557Ser Single submitter
- p.His145Gln Single submitter ⚠
- p.Ile206Leu Single submitter ⚠
- p.Ile303Val Single submitter ⚠
- p.Ile323Thr Single submitter ⚠
- p.Ile392Val Single submitter ⚠
- p.Ile436Leu Single submitter ⚠
- p.Ile541Val Single submitter ⚠
- p.Ile626Leu Single submitter ⚠
- p.Leu218Pro Single submitter ⚠
- p.Leu35Val Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Leu77Val Single submitter ⚠
- p.Lys52Thr Single submitter ⚠
- p.Met374Leu Single submitter ⚠
- p.Met492Leu Single submitter ⚠
- p.Phe143Leu Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro241Leu Single submitter ⚠
- p.Pro274Leu Single submitter ⚠
- p.Pro493Ala Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Pro642Leu Single submitter ⚠
- p.Ser18Leu Single submitter ⚠
- p.Ser542Leu Single submitter ⚠
- p.Thr281Ile Single submitter ⚠
- p.Thr463Met Single submitter
- p.Thr474Ile Single submitter ⚠
- p.Thr613Met Single submitter ⚠
- p.Thr99Ser Single submitter ⚠
- p.Trp528Arg Single submitter ⚠
- p.Tyr604His Single submitter ⚠
- p.Val175Met Single submitter ⚠
- p.Val223Ala Single submitter ⚠
- p.Val364Ile Single submitter ⚠
- p.Val394Ile Single submitter ⚠
- p.Val401Met Single submitter ⚠
- p.Val421Ile Single submitter ⚠
- p.Val440Ile Single submitter ⚠
- p.Val568Met Single submitter
- p.Val588Met Single submitter ⚠
- p.Val59Ile Single submitter ⚠