DUS4L — 28 ClinVar variants
All ClinVar germline DUS4L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Conflicting · 27 Uncertain significance
Full DUS4L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUS4L p.Ala62Thr Uncertain significance Single submitter
- DUS4L p.Ala70Pro Uncertain significance Single submitter
- DUS4L p.Gln118Arg Uncertain significance Single submitter
- DUS4L p.Gln195His Uncertain significance Single submitter
- DUS4L p.Gln7Arg Uncertain significance Single submitter
- DUS4L p.Ile10Val Uncertain significance Single submitter
- DUS4L p.Ile211Val Uncertain significance Single submitter
- DUS4L p.Ile219Val Uncertain significance Single submitter
- DUS4L p.Ile68Val Uncertain significance Single submitter
- DUS4L p.Lys15Glu Uncertain significance Single submitter
- DUS4L p.Lys39Glu Uncertain significance Single submitter
- DUS4L p.Met122Ile Uncertain significance Single submitter
- DUS4L p.Met58Val Uncertain significance Single submitter
- DUS4L p.Pro247Gln Uncertain significance Single submitter
- DUS4L p.Thr77Ile Uncertain significance Single submitter
- DUS4L p.Thr9Ile Uncertain significance Single submitter
- DUS4L p.Trp262Arg Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DUS4L p.Arg230Trp Uncertain significance Single submitter
- DUS4L p.Cys277Gly Uncertain significance Single submitter
- DUS4L p.Glu224Lys Uncertain significance Single submitter
- DUS4L p.Gly316Ala Uncertain significance Single submitter
- DUS4L p.Ile202Val Uncertain significance Single submitter
- DUS4L p.Ile205Leu Uncertain significance Single submitter
- DUS4L p.Ile261Met Uncertain significance Single submitter
- DUS4L p.Ser291Leu Uncertain significance Single submitter
- DUS4L p.Val103Ile Uncertain significance Single submitter
- DUS4L p.Val155Leu Uncertain significance Single submitter
All DUS4L variants
Conflicting classifications of pathogenicity 1
- c.-110-94C>A Single submitter COG5-congenital disorder of glycosylation
Uncertain significance 27
- p.Ala62Thr Single submitter ⚠
- p.Ala70Pro Single submitter ⚠
- p.Arg230Trp Single submitter ⚠
- p.Cys277Gly Single submitter ⚠
- p.Gln118Arg Single submitter ⚠
- p.Gln195His Single submitter ⚠
- p.Gln7Arg Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Gly316Ala Single submitter ⚠
- p.Ile10Val Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile205Leu Single submitter ⚠
- p.Ile211Val Single submitter ⚠
- p.Ile219Val Single submitter ⚠
- p.Ile261Met Single submitter ⚠
- p.Ile68Val Single submitter ⚠
- p.Lys15Glu Single submitter ⚠
- p.Lys39Glu Single submitter ⚠
- p.Met122Ile Single submitter ⚠
- p.Met58Val Single submitter ⚠
- p.Pro247Gln Single submitter ⚠
- p.Ser291Leu Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Thr9Ile Single submitter ⚠
- p.Trp262Arg Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val155Leu Single submitter ⚠