DUSP1 — 45 ClinVar variants
All ClinVar germline DUSP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 43 Uncertain significance
Full DUSP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP1 p.Ala197Ser Uncertain significance Single submitter
- DUSP1 p.Ala197Thr Uncertain significance Single submitter
- DUSP1 p.Ala202Thr Uncertain significance Single submitter
- DUSP1 p.Ala59Ser Uncertain significance Single submitter
- DUSP1 p.Ala92Asp Uncertain significance Single submitter
- DUSP1 p.Asn249Asp Uncertain significance Single submitter
- DUSP1 p.Asp330His Uncertain significance Single submitter
- DUSP1 p.Cys132Phe Uncertain significance Single submitter
- DUSP1 p.Cys210Ser Uncertain significance Single submitter
- DUSP1 p.Cys317Phe Uncertain significance Single submitter
- DUSP1 p.Gln23His Uncertain significance Single submitter
- DUSP1 p.Glu158Gly Uncertain significance Single submitter
- DUSP1 p.Ile40Val Uncertain significance Single submitter
- DUSP1 p.Leu109Phe Uncertain significance Single submitter
- DUSP1 p.Met143Lys Uncertain significance Single submitter
- DUSP1 p.Met60Thr Uncertain significance Single submitter
- DUSP1 p.Ser152Gly Uncertain significance Single submitter
- DUSP1 p.Ser310Phe Uncertain significance Single submitter
- DUSP1 p.Ser318Trp Uncertain significance Single submitter
- DUSP1 p.Thr333Ala Uncertain significance Single submitter
- DUSP1 p.Thr363Ala Uncertain significance Single submitter
- DUSP1 p.Val343Ile Uncertain significance Single submitter
- DUSP1 p.Val46Glu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- DUSP1 p.Ala103Val Uncertain significance Single submitter
- DUSP1 p.Ala113Gly Uncertain significance Single submitter
- DUSP1 p.Ala69Thr Uncertain significance Single submitter
- DUSP1 p.Asn228Ser Uncertain significance Single submitter
- DUSP1 p.Glu112Gln Uncertain significance Single submitter
- DUSP1 p.Glu19Lys Uncertain significance Single submitter
- DUSP1 p.Glu4Lys Uncertain significance Single submitter
- DUSP1 p.Gly38Ala Uncertain significance Single submitter
- DUSP1 p.Leu135Val Uncertain significance Single submitter
- DUSP1 p.Lys221Arg Uncertain significance Single submitter
- DUSP1 p.Phe243Tyr Uncertain significance Single submitter
- DUSP1 p.Pro315Leu Uncertain significance Single submitter
- DUSP1 p.Pro315Ser Uncertain significance Single submitter
- DUSP1 p.Ser152Ile Uncertain significance Single submitter
- DUSP1 p.Ser246Ala Uncertain significance Single submitter
- DUSP1 p.Thr101Ile Uncertain significance Single submitter
- DUSP1 p.Thr336Ile Uncertain significance Single submitter
- DUSP1 p.Thr362Met Uncertain significance Single submitter
- DUSP1 p.Val338Leu Uncertain significance Single submitter
- DUSP1 p.Val52Met Uncertain significance Single submitter
All DUSP1 variants
Uncertain significance 43
- p.Ala103Val Single submitter ⚠
- p.Ala113Gly Single submitter ⚠
- p.Ala197Ser Single submitter ⚠
- p.Ala197Thr Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala59Ser Single submitter ⚠
- p.Ala69Thr Single submitter ⚠
- p.Ala92Asp Single submitter ⚠
- p.Asn228Ser Single submitter ⚠
- p.Asn249Asp Single submitter ⚠
- p.Asp330His Single submitter ⚠
- p.Cys132Phe Single submitter ⚠
- p.Cys210Ser Single submitter ⚠
- p.Cys317Phe Single submitter ⚠
- p.Gln23His Single submitter ⚠
- p.Glu112Gln Single submitter ⚠
- p.Glu158Gly Single submitter ⚠
- p.Glu19Lys Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Gly38Ala Single submitter ⚠
- p.Ile40Val Single submitter ⚠
- p.Leu109Phe Single submitter ⚠
- p.Leu135Val Single submitter ⚠
- p.Lys221Arg Single submitter ⚠
- p.Met143Lys Single submitter ⚠
- p.Met60Thr Single submitter ⚠
- p.Phe243Tyr Single submitter ⚠
- p.Pro315Leu Single submitter ⚠
- p.Pro315Ser Single submitter ⚠
- p.Ser152Gly Single submitter ⚠
- p.Ser152Ile Single submitter ⚠
- p.Ser246Ala Single submitter ⚠
- p.Ser310Phe Single submitter ⚠
- p.Ser318Trp Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr333Ala Single submitter ⚠
- p.Thr336Ile Single submitter ⚠
- p.Thr362Met Single submitter ⚠
- p.Thr363Ala Single submitter ⚠
- p.Val338Leu Single submitter ⚠
- p.Val343Ile Single submitter ⚠
- p.Val46Glu Single submitter ⚠
- p.Val52Met Single submitter ⚠