DUSP10 — 56 ClinVar variants
All ClinVar germline DUSP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 55 Uncertain significance
Full DUSP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP10 p.Ala197Thr Uncertain significance Single submitter
- DUSP10 p.Ala300Thr Uncertain significance Single submitter
- DUSP10 p.Ala47Val Uncertain significance Single submitter
- DUSP10 p.Ala55Pro Uncertain significance Single submitter
- DUSP10 p.Ala99Ser Uncertain significance Single submitter
- DUSP10 p.Arg203Gln Uncertain significance Single submitter
- DUSP10 p.Arg203Trp Uncertain significance Single submitter
- DUSP10 p.Arg345Gln Uncertain significance Single submitter
- DUSP10 p.Arg428Gln Uncertain significance Single submitter
- DUSP10 p.Arg442Gln Uncertain significance Single submitter
- DUSP10 p.Arg69His Uncertain significance Single submitter
- DUSP10 p.Asn119Lys Uncertain significance Single submitter
- DUSP10 p.Asn184Ser Uncertain significance Single submitter
- DUSP10 p.Asp87Asn Uncertain significance Single submitter
- DUSP10 p.Glu364Lys Uncertain significance Single submitter
- DUSP10 p.Glu395Ala Uncertain significance Single submitter
- DUSP10 p.Gly107Arg Uncertain significance Single submitter
- DUSP10 p.Gly299Ser Uncertain significance Single submitter
- DUSP10 p.Gly299Val Uncertain significance Single submitter
- DUSP10 p.His357Arg Uncertain significance Single submitter
- DUSP10 p.Ile97Thr Uncertain significance Single submitter
- DUSP10 p.Leu423Met Uncertain significance Single submitter
- DUSP10 p.Lys142Arg Uncertain significance Single submitter
- DUSP10 p.Met117Val Uncertain significance Single submitter
- DUSP10 p.Pro113Leu Uncertain significance Single submitter
- DUSP10 p.Pro168Leu Uncertain significance Single submitter
- DUSP10 p.Pro447Leu Uncertain significance Single submitter
- DUSP10 p.Ser126Cys Uncertain significance Single submitter
- DUSP10 p.Ser126Pro Uncertain significance Single submitter
- DUSP10 p.Ser128Ile Uncertain significance Single submitter
- DUSP10 p.Ser138Pro Uncertain significance Single submitter
- DUSP10 p.Ser186Gly Uncertain significance Single submitter
- DUSP10 p.Ser30Arg Uncertain significance Single submitter
- DUSP10 p.Ser41Asn Uncertain significance Single submitter
- DUSP10 p.Ser41Thr Uncertain significance Single submitter
- DUSP10 p.Ser70Leu Uncertain significance Single submitter
- DUSP10 p.Thr102Asn Uncertain significance Single submitter
- DUSP10 p.Thr110Ala Uncertain significance Single submitter
- DUSP10 p.Thr124Lys Uncertain significance Single submitter
- DUSP10 p.Thr140Ile Uncertain significance Single submitter
- DUSP10 p.Thr342Ala Uncertain significance Single submitter
- DUSP10 p.Thr417Ser Uncertain significance Single submitter
- DUSP10 p.Val10Ile Uncertain significance Single submitter
- DUSP10 p.Val419Ile Uncertain significance Single submitter
- DUSP10 p.Val482Leu Uncertain significance Single submitter
- DUSP10 p.Val51Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DUSP10 p.Arg69Cys Uncertain significance Single submitter
- DUSP10 p.Asn184Lys Uncertain significance Single submitter
- DUSP10 p.Leu423Val Uncertain significance Single submitter
- DUSP10 p.Lys226Asn Uncertain significance Single submitter
- DUSP10 p.Met452Leu Uncertain significance Single submitter
- DUSP10 p.Pro266Leu Uncertain significance Single submitter
- DUSP10 p.Pro62Leu Uncertain significance Single submitter
- DUSP10 p.Ser77Arg Uncertain significance Single submitter
All DUSP10 variants
Likely benign 1
- p.Pro310Ser Single submitter
Uncertain significance 55
- p.Ala197Thr Single submitter ⚠
- p.Ala300Thr Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Ala55Pro Single submitter ⚠
- p.Ala99Ser Single submitter ⚠
- p.Arg203Gln Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg245Leu Single submitter
- p.Arg345Gln Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg442Gln Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg69His Single submitter ⚠
- p.Asn119Lys Single submitter ⚠
- p.Asn184Lys Single submitter ⚠
- p.Asn184Ser Single submitter ⚠
- p.Asp87Asn Single submitter ⚠
- p.Glu364Lys Single submitter ⚠
- p.Glu395Ala Single submitter ⚠
- p.Gly107Arg Single submitter ⚠
- p.Gly299Ser Single submitter ⚠
- p.Gly299Val Single submitter ⚠
- p.His357Arg Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Leu423Met Single submitter ⚠
- p.Leu423Val Single submitter ⚠
- p.Lys142Arg Single submitter ⚠
- p.Lys226Asn Single submitter ⚠
- p.Met117Val Single submitter ⚠
- p.Met452Leu Single submitter ⚠
- p.Pro113Leu Single submitter ⚠
- p.Pro168Leu Single submitter ⚠
- p.Pro266Leu Single submitter ⚠
- p.Pro447Leu Single submitter ⚠
- p.Pro62Leu Single submitter ⚠
- p.Ser126Cys Single submitter ⚠
- p.Ser126Pro Single submitter ⚠
- p.Ser128Ile Single submitter ⚠
- p.Ser138Pro Single submitter ⚠
- p.Ser186Gly Single submitter ⚠
- p.Ser30Arg Single submitter ⚠
- p.Ser41Asn Single submitter ⚠
- p.Ser41Thr Single submitter ⚠
- p.Ser70Leu Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Thr102Asn Single submitter ⚠
- p.Thr110Ala Single submitter ⚠
- p.Thr124Lys Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr342Ala Single submitter ⚠
- p.Thr417Ser Single submitter ⚠
- p.Val10Ile Single submitter ⚠
- p.Val419Ile Single submitter ⚠
- p.Val482Leu Single submitter ⚠
- p.Val51Met Single submitter ⚠