DUSP13B — 45 ClinVar variants
All ClinVar germline DUSP13B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
5 Benign · 3 Likely benign · 37 Uncertain significance
Full DUSP13B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP13B p.Pro161Gln Uncertain significance Multiple submitters
- DUSP13B p.Ala165Thr Uncertain significance Single submitter
- DUSP13B p.Ala256Asp Uncertain significance Single submitter
- DUSP13B p.Ala287Asp Uncertain significance Single submitter
- DUSP13B p.Arg146Gln Uncertain significance Single submitter
- DUSP13B p.Arg169His Uncertain significance Single submitter
- DUSP13B p.Arg174His Uncertain significance Single submitter
- DUSP13B p.Arg229Cys Uncertain significance Single submitter
- DUSP13B p.Arg257Gln Uncertain significance Single submitter
- DUSP13B p.Arg280Cys Uncertain significance Single submitter
- DUSP13B p.Arg280His Uncertain significance Single submitter
- DUSP13B p.Arg308His Uncertain significance Single submitter
- DUSP13B p.Arg318Gln Uncertain significance Single submitter
- DUSP13B p.Arg329Gln Uncertain significance Single submitter
- DUSP13B p.Arg333Gln Uncertain significance Single submitter
- DUSP13B p.Asp199His Uncertain significance Single submitter
- DUSP13B p.Asp247Asn Uncertain significance Single submitter
- DUSP13B p.Cys311Phe Uncertain significance Single submitter
- DUSP13B p.Gln205His Uncertain significance Single submitter
- DUSP13B p.His210Asp Uncertain significance Single submitter
- DUSP13B p.Leu145Phe Uncertain significance Single submitter
- DUSP13B p.Leu189Phe Uncertain significance Single submitter
- DUSP13B p.Leu320Val Uncertain significance Single submitter
- DUSP13B p.Pro161Leu Uncertain significance Single submitter
- DUSP13B p.Ser314Leu Uncertain significance Single submitter
- DUSP13B p.Thr331Met Uncertain significance Single submitter
- DUSP13B p.Val272Ala Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DUSP13B p.Ala262Gly Uncertain significance Single submitter
- DUSP13B p.Arg269Cys Uncertain significance Single submitter
- DUSP13B p.Arg269His Uncertain significance Single submitter
- DUSP13B p.Arg318Trp Uncertain significance Single submitter
- DUSP13B p.Arg326Gly Benign Single submitter
- DUSP13B p.Arg329Trp Uncertain significance Single submitter
- DUSP13B p.Arg333Trp Uncertain significance Single submitter
- DUSP13B p.Met276Leu Uncertain significance Single submitter
- DUSP13B p.Thr303Met Uncertain significance Single submitter
All DUSP13B variants
Benign 5
- p.Ala48Val Single submitter
- p.Arg326Gln Single submitter
- p.Arg326Gly Single submitter ⚠
- p.Cys292Tyr Single submitter
- p.Val35= Single submitter
Likely benign 3
- c.-153C>G Single submitter
- p.Asp183Asn Single submitter
- p.Val265Ile Single submitter
Uncertain significance 37
- p.Pro161Gln Multiple submitters ⚠
- c.582-1G>T Single submitter
- p.Ala165Thr Single submitter ⚠
- p.Ala256Asp Single submitter ⚠
- p.Ala262Gly Single submitter ⚠
- p.Ala287Asp Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg169His Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg280Cys Single submitter ⚠
- p.Arg280His Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg318Gln Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Arg329Gln Single submitter ⚠
- p.Arg329Trp Single submitter ⚠
- p.Arg333Gln Single submitter ⚠
- p.Arg333Trp Single submitter ⚠
- p.Asp199His Single submitter ⚠
- p.Asp247Asn Single submitter ⚠
- p.Cys311Phe Single submitter ⚠
- p.Gln205His Single submitter ⚠
- p.His210Asp Single submitter ⚠
- p.Leu145Phe Single submitter ⚠
- p.Leu189Phe Single submitter ⚠
- p.Leu320Val Single submitter ⚠
- p.Lys218Asn Single submitter
- p.Met276Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Ser314Leu Single submitter ⚠
- p.Thr303Met Single submitter ⚠
- p.Thr331Met Single submitter ⚠
- p.Val272Ala Single submitter ⚠