DUSP14 — 25 ClinVar variants
All ClinVar germline DUSP14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely benign · 24 Uncertain significance
Full DUSP14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP14 p.Arg117Gly Uncertain significance Single submitter
- DUSP14 p.Arg163His Uncertain significance Single submitter
- DUSP14 p.Arg190Gln Uncertain significance Single submitter
- DUSP14 p.Arg45Gln Uncertain significance Single submitter
- DUSP14 p.Arg4Ser Uncertain significance Single submitter
- DUSP14 p.Asn44Ser Uncertain significance Single submitter
- DUSP14 p.Asn67Ser Uncertain significance Single submitter
- DUSP14 p.Asp183Asn Uncertain significance Single submitter
- DUSP14 p.Gly52Arg Uncertain significance Single submitter
- DUSP14 p.Gly87Glu Uncertain significance Single submitter
- DUSP14 p.His191Tyr Uncertain significance Single submitter
- DUSP14 p.Ile180Val Uncertain significance Single submitter
- DUSP14 p.Ile30Val Uncertain significance Single submitter
- DUSP14 p.Ile56Val Uncertain significance Single submitter
- DUSP14 p.Ile61Thr Uncertain significance Single submitter
- DUSP14 p.Leu165Val Uncertain significance Single submitter
- DUSP14 p.Pro16Ser Uncertain significance Single submitter
- DUSP14 p.Ser99Asn Uncertain significance Single submitter
- DUSP14 p.Tyr185Cys Uncertain significance Single submitter
- DUSP14 p.Val132Met Uncertain significance Single submitter
- DUSP14 p.Val171Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DUSP14 variants
Likely benign 1
- p.Thr120= Single submitter
Uncertain significance 24
- p.Arg117Gly Single submitter ⚠
- p.Arg163His Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg4Ser Single submitter ⚠
- p.Asn44Ser Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asp183Asn Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.Gly52Arg Single submitter ⚠
- p.Gly87Glu Single submitter ⚠
- p.His191Tyr Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile56Val Single submitter ⚠
- p.Ile61Thr Single submitter ⚠
- p.Leu165Val Single submitter ⚠
- p.Phe66Leu Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Ser169Leu Single submitter ⚠
- p.Ser99Asn Single submitter ⚠
- p.Tyr185Cys Single submitter ⚠
- p.Val132Met Single submitter ⚠
- p.Val171Ile Single submitter ⚠