DUSP16 — 77 ClinVar variants
All ClinVar germline DUSP16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Benign · 4 Likely benign · 71 Uncertain significance
Full DUSP16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DUSP16 p.Ala2Thr Uncertain significance Single submitter
- DUSP16 p.Ala358Thr Uncertain significance Single submitter
- DUSP16 p.Ala73Val Uncertain significance Single submitter
- DUSP16 p.Arg130His Uncertain significance Single submitter
- DUSP16 p.Arg14Lys Uncertain significance Single submitter
- DUSP16 p.Arg208His Uncertain significance Single submitter
- DUSP16 p.Arg483Gln Uncertain significance Single submitter
- DUSP16 p.Arg598Cys Uncertain significance Single submitter
- DUSP16 p.Arg611Gln Uncertain significance Single submitter
- DUSP16 p.Asn165Ser Uncertain significance Single submitter
- DUSP16 p.Asp89Asn Uncertain significance Single submitter
- DUSP16 p.Gln454Arg Uncertain significance Single submitter
- DUSP16 p.Gln9His Uncertain significance Single submitter
- DUSP16 p.Glu24Gly Uncertain significance Single submitter
- DUSP16 p.Glu348Lys Uncertain significance Single submitter
- DUSP16 p.Glu639Lys Uncertain significance Single submitter
- DUSP16 p.Gly303Glu Uncertain significance Single submitter
- DUSP16 p.Gly306Arg Uncertain significance Single submitter
- DUSP16 p.Gly330Arg Uncertain significance Single submitter
- DUSP16 p.Gly438Arg Uncertain significance Single submitter
- DUSP16 p.Gly493Ser Uncertain significance Single submitter
- DUSP16 p.Gly520Ser Uncertain significance Single submitter
- DUSP16 p.Gly633Val Uncertain significance Single submitter
- DUSP16 p.His3Asn Uncertain significance Single submitter
- DUSP16 p.Ile42Val Uncertain significance Single submitter
- DUSP16 p.Ile572Thr Uncertain significance Single submitter
- DUSP16 p.Leu142Pro Uncertain significance Single submitter
- DUSP16 p.Leu245Ser Uncertain significance Single submitter
- DUSP16 p.Leu518Phe Uncertain significance Single submitter
- DUSP16 p.Lys297Gln Uncertain significance Single submitter
- DUSP16 p.Lys297Met Uncertain significance Single submitter
- DUSP16 p.Lys470Gln Uncertain significance Single submitter
- DUSP16 p.Lys470Met Uncertain significance Single submitter
- DUSP16 p.Pro368Arg Uncertain significance Single submitter
- DUSP16 p.Pro375Leu Uncertain significance Single submitter
- DUSP16 p.Ser148Phe Uncertain significance Single submitter
- DUSP16 p.Ser309Arg Uncertain significance Single submitter
- DUSP16 p.Ser309Gly Uncertain significance Single submitter
- DUSP16 p.Ser327Leu Uncertain significance Single submitter
- DUSP16 p.Ser359Gly Uncertain significance Single submitter
- DUSP16 p.Ser365Arg Uncertain significance Single submitter
- DUSP16 p.Ser369Leu Uncertain significance Single submitter
- DUSP16 p.Ser421Cys Uncertain significance Single submitter
- DUSP16 p.Ser452Leu Uncertain significance Single submitter
- DUSP16 p.Ser486Leu Uncertain significance Single submitter
- DUSP16 p.Ser501Pro Uncertain significance Single submitter
- DUSP16 p.Ser508Thr Uncertain significance Single submitter
- DUSP16 p.Ser583Asn Uncertain significance Single submitter
- DUSP16 p.Ser635Ile Uncertain significance Single submitter
- DUSP16 p.Thr141Ala Uncertain significance Single submitter
- DUSP16 p.Thr529Met Uncertain significance Single submitter
- DUSP16 p.Thr548Ile Uncertain significance Single submitter
- DUSP16 p.Tyr567Cys Uncertain significance Single submitter
- DUSP16 p.Val407Ile Uncertain significance Single submitter
- DUSP16 p.Val509Met Uncertain significance Single submitter
- DUSP16 p.Val594Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DUSP16 p.Arg611Trp Uncertain significance Single submitter
- DUSP16 p.Arg625Cys Uncertain significance Single submitter
- DUSP16 p.Asp61Glu Uncertain significance Single submitter
- DUSP16 p.Glu269Lys Uncertain significance Single submitter
- DUSP16 p.Ile281Val Uncertain significance Single submitter
- DUSP16 p.Leu402Pro Uncertain significance Single submitter
- DUSP16 p.Lys110Arg Uncertain significance Single submitter
- DUSP16 p.Lys177Glu Uncertain significance Single submitter
- DUSP16 p.Pro144Arg Uncertain significance Single submitter
- DUSP16 p.Ser91Ile Uncertain significance Single submitter
All DUSP16 variants
Benign 2
- c.229-7A>C Single submitter
- p.Pro361fs Single submitter
Likely benign 4
Uncertain significance 71
- p.Ala2Thr Single submitter ⚠
- p.Ala358Thr Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg130His Single submitter ⚠
- p.Arg14Lys Single submitter ⚠
- p.Arg208His Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg598Cys Single submitter ⚠
- p.Arg611Gln Single submitter ⚠
- p.Arg611Trp Single submitter ⚠
- p.Arg625Cys Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asp61Glu Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Gln454Arg Single submitter ⚠
- p.Gln9His Single submitter ⚠
- p.Glu203Lys Single submitter
- p.Glu24Gly Single submitter ⚠
- p.Glu269Lys Single submitter ⚠
- p.Glu348Lys Single submitter ⚠
- p.Glu639Lys Single submitter ⚠
- p.Gly303Glu Single submitter ⚠
- p.Gly306Arg Single submitter ⚠
- p.Gly330Arg Single submitter ⚠
- p.Gly438Arg Single submitter ⚠
- p.Gly493Ser Single submitter ⚠
- p.Gly520Ser Single submitter ⚠
- p.Gly633Val Single submitter ⚠
- p.His205Tyr Single submitter
- p.His3Asn Single submitter ⚠
- p.Ile259Val Single submitter
- p.Ile281Val Single submitter ⚠
- p.Ile42Val Single submitter ⚠
- p.Ile572Thr Single submitter ⚠
- p.Leu142Pro Single submitter ⚠
- p.Leu245Ser Single submitter ⚠
- p.Leu402Pro Single submitter ⚠
- p.Leu518Phe Single submitter ⚠
- p.Lys110Arg Single submitter ⚠
- p.Lys177Glu Single submitter ⚠
- p.Lys297Gln Single submitter ⚠
- p.Lys297Met Single submitter ⚠
- p.Lys470Gln Single submitter ⚠
- p.Lys470Met Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro368Arg Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Ser148Phe Single submitter ⚠
- p.Ser309Arg Single submitter ⚠
- p.Ser309Gly Single submitter ⚠
- p.Ser327Leu Single submitter ⚠
- p.Ser359Gly Single submitter ⚠
- p.Ser365Arg Single submitter ⚠
- p.Ser369Leu Single submitter ⚠
- p.Ser421Cys Single submitter ⚠
- p.Ser452Leu Single submitter ⚠
- p.Ser452Trp Single submitter
- p.Ser486Leu Single submitter ⚠
- p.Ser501Pro Single submitter ⚠
- p.Ser508Thr Single submitter ⚠
- p.Ser583Asn Single submitter ⚠
- p.Ser635Ile Single submitter ⚠
- p.Ser656Leu Single submitter
- p.Ser91Ile Single submitter ⚠
- p.Thr141Ala Single submitter ⚠
- p.Thr529Met Single submitter ⚠
- p.Thr548Ile Single submitter ⚠
- p.Tyr567Cys Single submitter ⚠
- p.Val407Ile Single submitter ⚠
- p.Val509Met Single submitter ⚠
- p.Val594Ile Single submitter ⚠